Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Protein Loop"”.
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Protein Loop Length Estimation From Medium Resolution Cryoem Images
… presents a new frontier in life science. Proteins play roles in virtually every biological process, and understanding their atomic structures is the key to unraveling how they carry out their work. Compared to the over half million protein sequences in UniProt, only around 25,000 unique …
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Building a Genetic System in Yeast to Search for High Affinity Proteins in Sequence Space
Binding proteins (both natural and man-made) have the ability to bind tightly and specifically with small molecules and other biopolymers. Binding proteins can function as human therapeutics, diagnostics, and as tools for scientific research. Given the wide range of potential applications, there is …
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Information-Based Torsion Angle Potential for Proteins and Applications
… alternative to physical potentials in protein structure prediction and design. As an introduction we survey the aspects and methods involved in the derivation and applicability of various statistical potentials. The statistical potential created in this work is based on a reduced …
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Protein-Protein Interactions and Small Molecule Targeting of the Multisubunit SOCS2-EloBC-Cul5-Rbx2 E3 Ubiquitin Ligase
… biological processes determining the fate of proteins by catalysing ubiquitin transfer to specific substrates for proteasomal degradation. SOCS2 is a component of the multisubunit CRL E3 complex (CRL5<sup>SOCS2</sup>). SOCS2 plays important roles in several cancers and is involved in diabetes …
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Inhibiting Protein-Protein Interactions using Rationally-designed Repeat Proteins
The inhibition of protein-protein interactions (PPIs) presents a major challenge to drug discovery. The properties of consensus-designed tetratricopeptide repeat proteins (CTPRs) make them very amenable to be rationally-designed into potential new PPI inhibitors. This study sets out to investigate …