Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 91 for “"Protein Kinase C (PKC)"”.
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A Mis-Expression Screen Identifies a PKA -Anchoring Protein in Antenna Lobe Development
One of the genes recovered was the Drosophila A Kinase anchoring protein 200 (Akap200). This thesis discusses the further characterization of this gene. Akap200 is a Protein Kinase A (PKA) binding protein with multiple binding sites for other signaling molecules, including Protein Kinase C (PKC), …
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Toward the design, synthesis and evaluation of Protein Kinase C inhibitors
Protein Kinase C (PKC) represents an important regulatory element in the signal transduction pathways of mammalian cells. Research interest has increased enormously since the discovery that PKC plays critical roles in cell differentiation, tumor promotion, oncogenesis and cell regulatory processes. …
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Role of glutamate in lead-induced toxicity: protection by N-acetylcysteine amide (NACA), a novel thiol antioxidant
… cellular processes, and activation of protein kinase C (PKC) resulting in oxidative stress. Chelation therapy has been a choice to reduce the body burden of lead; however chelation does not eliminate the neurotoxicity of lead...In this study we propose to evaluate the involvement of …
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Effect of Soyasaponin Fractions on Human Colon Cancer Cells
… of purified soyasaponins on cell proliferation, Protein Kinase C (PKC) activity, and cell morphology in cultures of Caco-2 cells. Treatment of cells with soyasaponins I and III at concentrations of 300-900 ppm significantly reduced viable cell numbers after 48 and 72 hours of exposure by 10-35% …
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The effects of a 1.8 GHz continuous electromagnetic fields on mucociliary transport of human nasal mucosa
… the two groups. In the EMF-exposed group, protein kinase C (PKC) activity was increased during a PKC activity assay. The broad PKC inhibitor, Calphostin C abolished the EMF-induced decrease of CBF. The EMF-induced decrease of CBF was abolished by GF 109203X, a novel PKC (nPKC) isoform …
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Überexpression von s-Adenosylhomocystein-Hydrolase (SAH) in Zellen der Epstein-Barr Virus-Genom positiven Zell-Linie B95-8
… to an increase of phosphorylated and activated protein kinase C (PKC). The lytic cycle might be activated additionally using a PKC and PLA2 independent way.The rate of DNA synthesis and cell proliferation increased significantly in pcDNA-AHCY transfected B95-8 cells. A modulated expression of …
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Observing the effects of acetylcholinesterase and brain-derived neurotrophic factor on the levels of soluble amyloid precusor protein α in lung cancer cell media
… to this the levels of soluble amyloid precursor protein α (sAPPα) were higher in H1299 cell media compared to A549 cell media. With these previous findings, we hypothesize that the levels of sAPPα are regulated by AChE and mBDNF. When cells were treated with AChE, sAPPα levels were decreased …
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Regulation of HIF-1α during Hypoxia by DAP5-Induced Translation of PHD2
<p>Death associated protein 5 (DAP5) is an atypical isoform of the translation initiation scaffold eukaryotic initiation factors 4GI and II (eIF4GI/II), which recruit mRNAs to ribosomes in mammals. Unlike eIF4GI/II, DAP5 binds eIF2β, a subunit of the eIF2 complex that delivers methionyl-tRNA to …
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Epidermal growth factor-mediated activation of the unliganded glucocorticoid receptor in A549 cells
… via the TLR-2 receptor but not via the protein kinase C (PKC) pathway. The EGF response is shown to act via the nuclear factor kappa B (NF-κB) promoter element in a GR-dependent manner. Some mechanistic insights into the regulation are provided by demonstrating that EGF results in …
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Roles of protein kinase C in cell death and breast cancer
Aberrant protein kinase C (PKC) activity and expression is implicated in different malignancies. To study the role of different PKC isoforms in breast cancer the expression of PCKα, δ and ε was evaluated in breast cancer tumors. In addition the effect of siRNA-mediated knockdown of the isoforms was …
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Role of protein kinase C isoforms in human breast tumor cell survival
Protein kinase C (PKC) is a family of serine/threonine kinases composed of 12 unique isoforms that function in a variety of cellular processes including proliferation, apoptosis, differentiation and carcinogenesis. The contribution of individual PKC isoforms to these processes is largely …
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Functional Interactions Between Par-1b Protein Kinase and RNF41 E3 Ubiquitin Ligase
<p>The Par-1 family of serine/threonine protein kinases functions to regulate cell polarity and is conserved from yeast to humans. Par-1 is encoded by one of six Par: partitioning-defective) genes: Par-1-6) originally identified in a genetic screen conducted in Caenorhabditis elegans: C. elegans). …
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The Effects of Atypical Protein Kinase C on TGFβ Signalling
… In this thesis, I examined the role of Protein Kinase C (PKC) in the regulation of TGFβ signalling pathways and found that the Atypical PKC isoforms (aPKC; a subgroup of the PKC family) indeed can alter TGFβ receptor signaling. My work has shown that the modulation of aPKC expression or …
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Molecular control of endothelial lumen formation by Rho GTPases in three dimensional collagen matrices
… formation process in a manner that depends on protein kinase C (PKC)-mediated signaling. We identify PKC[epsilon] and PKC[zeta] as regulators of EC lumenogenesis in 3D collagen matrices. We further show that Src family kinases (SFKs) are involved in this PKC [epsilon]-mediated EC lumen …
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Importance of MAPK and PKC in cerebrovascular endothelin receptor changes
… studies have shown an involvement of protein kinase C (PKC) and extracellular signal-regulated kinases (ERK) 1/2 in ischemia. The aim of this thesis was to further elucidate the mechanisms underlying this receptor upregulation process, both in experimental ischemia and in organ culture …
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Targeting Myeloid Protein Kinase C Signaling to Overcome Immune Suppression and Improve Immunotherapy in Cancer
… we first investigated the effect of protein kinase C (PKC) agonist PEP005 on MDSC expansion, differentiation, and recruitment to the tumor microenvironment. We found that PKC agonists decreased MDSC expansion from the bone marrow and induced MDSC differentiation to an APC-like …
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Localisation of Protein Kinase C in Apoptosis and Neurite Outgrowth
Protein kinase C (PKC) is a family of serine/threonine kinases, which are subgrouped into classical (a, bI, bII, g), novel (d, e, h, q) and atypical (z, i/l) isoforms. One major aim of this thesis work was to investigate if altered levels of PKC isoforms influence the apoptotic responses of …
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Activation of the Transient Receptor Potential Vanilloid-1 (TRPV1) channel mediates Extracellular Signal Regulated Kinase (ERK) phosphorylation via Beta-arrestin-2 signaling
… a possible role for β-arrestin-2, a scaffolding protein that mediates G-protein coupled receptor desensitization, in channel regulation. Interestingly, β-arrestin-2 also acts as a signaling scaffold for the MAPK (ERK1/2) pathway which was described as an important nociceptive marker. In this …
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AKR1B10 PROMOTES BREAST CANCER METASTASIS THROUGH INTEGRIN α5/δ-CATENIN-RAC1 SIGNALING PATHWAY
… the integrin α5-mediated focal adhesion kinase (FAK) signaling pathway which, together with δ-catenin, stimulated Rac1-mediated cell migration and movement. Furthermore, we found that in these cancer cells, AKR1B10 activated protein kinase C (PKC) which in turn activated the …
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Analysis of Novel Genes Whose mRNAs are Enriched in the HVC-Associated Telencephalon of Songbirds
… of the analysis was to determine what kind of protein is encoded by each RNA, whether the RNA distinguishes sites of defined neural plasticity (i.e., the telencephalic song control nuclei or the neurogenic ventricular zone), and whether the RNA's abundance changes at times when anatomical and …
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