Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"Protein Kinase B"”.
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Serine/threonine phosphorylation in mycobacterium tuberculosis : identification of protein kinase B (PknB) substrates
… is poorly understood. PknB is a serine/threonine kinase essential for the in vitro survival of M. tuberculosis and therefore a potential drug target against the bacteria. It is the goal of the current study to elucidate downstream substrates of PknB. We have found that PknB shares in vitro …
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Modulation of the NFAT signaling pathway by protein kinase B (PKB) ; a perspective study in the context of thymocyte development and T cell function
To analyze the role of protein kinase B(PKB)on developmental and functional aspects of T cells, we have generated transgenic mouse lines expressing a constitutively active form of PKB (myrPKB) in early stages of T cell development.Peripheral CD4+ T cells from PKB tg mice are hyperreactive, more …
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The effects of resistance training on individuals with clusters of metabolic risk factors: focus on functional capacities, clinical outcomes and quality of life
… the effects of RT on the insulin signalling proteins, Akt (protein kinase B) and Akt substrate of 160 kDa (AS 160), and muscle glycogen stores for individuals with HiMF or LoMF.
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Human neural stem cells over-expressing Akt1 provide cytoprotection and functional recovery in mouse stroke model
Akt1 (protein kinase B), a serine/threonine kinase, has emerged as a critical molecule in signal transduction pathways involved in cell proliferation, growth, survival, apoptosis and glucose metabolism. A previous study has shown that transplanted human neural stem cells (hNSCs) selectively migrate …
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Hormonal regulation of phosphodiesterase 3B in adipocytes
… of PDE3B and PDE3B interactions with other proteins. As models to study activation of PDE3B we used primary rat and mouse adipocytes, 3T3-L1 adipocytes and caveolin-1 knock out mouse adipocytes. The study on PDE3B phosphorylation shows that PDE3B is multisite phosphorylated in response to …
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A screen for phosphatidylinositol 3,4-bisphosphate and other 3-phosphoinositide effector proteins
Class I phosphoinositide (PI) 3-kinases exert profound effects on cell growth, division, motility and metabolism via their primary lipid product phosphatidylinositol 3,4,5- trisphosphate (PtdIns(3,4,5)P3) and a metabolite of this, phosphatidylinositol 3,4- bisphosphate (PtdIns(3,4)P2). Many …
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Dietary amino acids and their contribution to de novo lipogenesis
… in the form of sugary beverages, fat, and protein from red meat. The aim of this thesis was to investigate the effect of changing the solid/liquid ratio of meals on gastric emptying as well as the effect of changing meal compositions on lipid metabolism. A 5-way crossover human study …
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Use of Kinase Inhibitors to Illuminate Signaling Pathways in Breast Cancer
… factor receptor 2 positive (HER-2+). HER-2 is a protein receptor located on the cell surface that interacts with other proteins and signaling molecules to translate extracellular signals into cellular process such as cell growth and replication. However, in breast cancer, there is a drastic …
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The expression and signalling patterns of CD180 toll like receptor in Chronic Lymphocytic Leukaemia (CLL)
… involving phosphatidylinositol-4,5-bisphosphate3-kinase (PI3K) and protein kinase B (AKT) to the potentially pro-apoptotic pathway through mitogen-activated protein kinase (p38MAPK). However, little is known about the function of the other BCR - sIgD in CLL and its possible interaction with CD180. …
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Investigations of Novel Mechanisms of Action for Anti-Bacterial and Anti-Cancer Agent Development
… a substrate-competitive covalent inhibitor for protein kinase B (AKT). AKT is a valid target for cancer research with two compounds currently in late stage clinical trials. Developing substrate- competitive inhibitors for kinases is a novel approach in targeting them, with very few examples in …
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The Role of K63-Linked Ubiquitination Cycles In Akt Kinase Activation
<p>Akt (also known as protein kinase B) serves a central regulator in PI3K/Akt signaling pathways to regulate numerous physiological functions including cell proliferation, survival and metabolism. Akt activation requires the binding of Akt to phospholipid PIP3 on the plasma membrane and subsequent …
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The Influence of Chromium Supplementation on the Insulin Pathway, Carcass Traits, and Meat Quality of Feedlot Steers
… muscle (LM) biopsies were collected to examine protein abundance and gene expression after adaptation to a terminal implant and after adaption to ractopamine hydrochloride (RAC). A follow up study, Experiment 2, was conducted with yearling steers supplemented 0 ppb (CON) or 300 ppb Cr propionate …
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Design and development of novel tools for the screening and identification of inhibitors of HER receptor family and NFR2 for ovarian cancer therapy
… receptors, HER1 and HER4, elevates phospho protein kinase B (pAKT) levels, and enhances the proliferation of ovarian cancer cells. Pharmacological inhibition using retinoic acid (RA) and bexarotene and genetic inhibition using small interfering RNA (siRNA), did the opposite. Further, tBHQ …
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Investigation of Cellular Responses Activated by Mechanical Compression in Equine Chondrocytes: Device Design, Construction and Testing
… in expression of collagen II and matrix metalloproteinase-3 under dynamic compression for 24 hr. Equine chondrocytes compressed for 48 hr showed lower PG synthesis for both static and dynamic compression when compared to uncompressed samples in replicate experiments. Repeatability of this …
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Metabolic and endocrine adaptations to heat stress in lactating dairy cows
… muscle insulin sensitivity in terms of reduced protein kinase B (PKB/AKT) phosphorylation, a downstream protein of insulin receptor (IR), while HS group maintained similar intact insulin responsiveness in the liver and skeletal muscle as thermoneutral conditions. There was a global reduction in …
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The Physiology of Enhanced Milk Yield Through Increased Milking Frequency in Early Lactation
… in which IMF enhanced MY involved increased protein levels of signal transducer and activator of transcription (STAT5), activated and total protein kinase B (Akt), and total extracellular signal-regulated kinase 1 and 2 (ERK1/2) and reduced protein levels of total mammalian target of …
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Combined Inhibition of Ddr1 and Cdk4/6 Induces Synergistic Effects In Er-Positive, Her2-Negative Breast Cancer With Pik3Ca/Akt1 Mutations
… alterations in the phosphatidylinositol 3‑kinase (PI3K)/ serine/threonine protein kinase B (AKT) signaling pathway occur frequently in estrogen receptor–positive (ER-positive) breast tumors. Patients with ER-positive, human epidermal growth factor receptor 2–negative (HER2-negative) …
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Extracellular Superoxide Dismutase Protects Cardiomyocytes During Hyperoxia
… and Tfam increased in these mice.</p> <p>The protein expression of the pro-survival Protein Kinase B (Akt) was significantly increased by hyperoxia in the TG hearts after 6 hours (<em>p</em>pp</p> <p>In conclusion, systemic hyperoxia consistently increases mitochondrial biogenesis markers in …
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Investigating the role of ACSS2-mediated acetyl-CoA metabolism on EGFR-PI3K-PKB signalling
… of the EGFR, including the phosphoinositide-3-kinase (PI3K)-protein kinase B (PKB) pathway. This pathway is not only essential for cellular function, but has also been commonly implicated in the diseased state, including cancer and immunological deficiencies, therefore understanding its …
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Glioma produced periostin attracts human neural stem cells
… type of brain tumors and identified 14 secretory proteins that were highly and specifically expressed in brain tumors. Real-time PCR assay and immunohistochemistry with various brain tumor samples showed that periostin (POSTN) among these factors, known for its role in angiogenesis and invasion …
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