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Showing 1 to 20 of 974 for “"Protein Kinase"”.

  1. Plasmodium falciparum protein kinase CK2

    Holland, ZoeUniversity of Glasgow2008

    … (Ridley, 2002). Reversible phosphorylation of proteins is a major regulatory mechanism in most cellular processes, and protein kinases are considered promising drug targets, comprising as much as 30% of all protein targets under investigation (Cohen, 2002). The divergences between human and …

    glasgow Repository record

  2. Regulation of Protein Kinase D

    Matthews, SharonUniversity College London2000

    dundee Repository record

  3. The evolution of protein kinase specificity

    Bradley, DavidUniversity of Cambridge2019

    Protein phosphorylation represents one of the most important post-translational modifica- tions (PTMs) for cell signalling, and is is catalysed by a group of enzymes called protein kinases. Through this activity they serve as key regulators of almost all cellular processes. This is achieved at any …

    cambridge Repository record

  4. Characterization of zebrafish zipper-interacting protein kinase

    Carr, Brandon W.2018

    <p>Zipper-Interacting Protein Kinase (ZIPK) is a known modulator of actin-myosin contractility in vertebrate species. Interestingly, rodent and mouse ZIPK has undergone a divergence in regulation in comparison to other vertebrate orthologs including human. Whereas the human ortholog of ZIPK …

    u-pacific Repository record

  5. Molecular Mechanism of Zipper Interacting Protein Kinase

    Chambers, Jenica Annmarie2011

    … calcium/calmodulin regulated myosin light chain kinase (MLCK) and smooth muscle myosin phosphatase (SMPP-1M) determine the amount of force generated by smooth muscle. The calcium-independent signaling mediated by myosin phosphatase is regulated by several kinases which include zipper interacting …

    duke Repository record

  6. AMP-activated protein kinase and muscle metabolism

    Scheffler, Tracy L.Virginia Tech2012

    AMP-activated protein kinase (AMPK) is a major regulator of skeletal muscle metabolism with relevance to agriculture and human health. During the conversion of muscle to meat, the rate and extent of postmortem metabolism and pH decline largely determine pork quality development. Pigs with the …

    vt Repository record

  7. Investigating the regulation of the PCTAIRE-1 protein kinase : a new target of AMP-activated protein kinase and beyond?

    Shehata, SaifUniversity of Dundee2012

    PCTK1 is a Cdc2-related protein kinase that is poorly characterised. Several studies have investigated its role and regulation, and have provided some insight into its upstream regulation by PKA/CDK5 phosphorylation. Proposed physiological functions include vesicle trafficking and neurite …

    dundee Repository record

  8. Atpase and Protein Kinase in Membranes From Corn Roots: Regulation of Tonoplast Atpase by Calmodulin or by Protein Kinase

    Ladror, Uri ShlomoUniversity of Illinois at Urbana-Champaign2015

    … by Ca('2+)- or calmodulin (CaM)-dependent protein phosphorylation. This work included: (a) identifying the microsomal H('+)-ATPases; (b) characterizing protein kinase and phosphatase activities in microsomal fractions; (c) finding whether conditions that lead to protein phosphorylation …

    uiuc Repository record

  9. Development of bisubstrate inhibitors for protein kinase CK2

    Vahter, Jürgen2019

    tartu

  10. Fluorometric assays for characterization of protein kinase inhibitors

    Vaasa, Angela2006

    tartu

  11. Interaction Mapping of the Atypical Protein Kinase WNK3

    Self, Jon Tate2010

    The story of the protein kinase "with no lysine 3" (WNK3) represents a unique chapter in the larger story of protein kinases, the so-called 'molecular switches' of the cell that serve the vital function of phosphorylating myriad proteins. In doing so, these enzymes furnish the cell with one of the …

    utswmed Repository record

  12. Purification and Activity of the PP60SRC Protein Kinase

    Greenberg, Michael E

    … from the action of a single virally coded phosphoprotein with a molecular weight of 60,000 daltons (pp60<sup>src</sup>). The expression of pp60<sup>src</sup> results in many significant changes in the cell's phenotype which include disruption of the cytoskeleton and the deregulation of cell …

    rockefeller Repository record

  13. How is Ataxia-Telangiectasia Mutated Protein Kinase Activated?

    Howes, AnnaUniversity of Cambridge2022

    Ataxia-Telangiectasia Mutated (ATM) is a key protein kinase in the cell’s response to double-stranded breaks in DNA. This damage is detected by the Mre11-Rad50-Nbs1 (MRN) complex, which recruits ATM to the DNA. Upon activation, ATM phosphorylates a vast range of substrates, which triggers a …

    cambridge Repository record

  14. AMP-activated protein kinase kinase activity and phosphorylation of AMP-activated protein kinase in contracting muscle of sedentary and endurance trained rats

    Hurst, Denise2007

    … designed to examine activity of AMP-activated protein kinase kinase (AMPKK) and AMP-activated protein kinase (AMPK) in muscles from control (C) and endurance trained (T) rats. Rats were trained 5 days/wk, 2 hr/d for 8 wks at a final intensity of 32 m/min up a 15% grade with 30 second sprints at …

    byu Repository record

  15. Characterization of the zebrafish zipper interacting protein kinase homolog

    Basepayne, Tamara Lee2018

    … of 6 zebrafish Zipper Interacting Protein Kinase homolog has helped to better understand how changes in cell cytoskeletal elements can lead to changes in cell shape and movement. Zebrafish are ideal model organisms for studying ZIPK because it has been previously shown that …

    u-pacific Repository record

  16. Functional Aspects of Protein Kinase C FRET Probe Performance

    Jost, ChristianeUniversität Heidelberg

    … influencing the performance of two FRET based protein kinase C (PKC) probes, KCP-1 and KCP-2. KCP-1 consists of the truncated PKC substrate pleckstrin, sandwiched between two fluorescent proteins, EYFP and GFP2. KCP-2 is a shortened version of KCP-1, missing the last 18 amino acids of the …

    heid-diss Repository record

  17. Identification of novel protein kinase regulators of TGFβ signalling

    Hutchinson, LukeUniversity of Dundee2019

    … inhibitors that target the salt-inducible kinases (SIKs) are able to attenuate the TGFβ-mediated transcriptional regulation of specific target genes. Moreover, this transcriptional attenuation occurred without affecting the receptor-mediated phosphorylation of the R-SMAD transcription …

    dundee Repository record

  18. Interaction of Heterotrimeric Go Protein with Protein Kinase A

    윤, 상필2012

    Master

    ajou Repository record

  19. DYSREGULATION OF AMP-ACTIVATED PROTEIN KINASE SIGNALING IN ALZHEIMER’S DISEASE

    Wang, XinWake Forest University2018

    … mechanism of Alzheimer’s disease. AMP-activated protein kinase (AMPK) is a master energy sensor which can sense the ratio of AMP/ATP and regulates catabolic and anabolic pathways to keep the energy metabolism in balance, and has been found to play an important role in the pathogenesis of …

    wfu Repository record

  20. The Effects of Atypical Protein Kinase C on TGFβ Signalling

    Gunaratne, Adrian DThe University of Western Ontario2014

    … In this thesis, I examined the role of Protein Kinase C (PKC) in the regulation of TGFβ signalling pathways and found that the Atypical PKC isoforms (aPKC; a subgroup of the PKC family) indeed can alter TGFβ receptor signaling. My work has shown that the modulation of aPKC expression or …

    uwo Repository record

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