Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 740 for “"Protein Interactions"”.
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Ligand-Protein Interactions in Cytochromes
… an essential role in life processes. The two proteins studied in this thesis, cytochrome P450 carries out enzymatic reactions, metabolizes drugs, and synthesizes steroids while cytochrome c553 is a protein involved in electron transfer and photosynthesis. Despite the diverse functions …
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Understanding small molecule-protein interactions
The binding of small molecules to a protein is among the most important phenomena in the chemistry of life; the activity and functionality of many proteins depend critically on binding small molecules. A deep understanding of protein-small molecule interactions and the interplay between ligation …
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Lipid-protein interactions in lipid membranes
In dieser Arbeit werden Lipid-Protein-Wechselwirkungen und lipidvermittelte Protein-Protein-Wechselwirkungen mittels Monte-Carlo-Simulationen eines generischen vergröberten Modells für Lipiddoppelschichten mit hydrophoben Einschlüssen untersucht. Die Ergebnisse werden mit den Vorhersagen zweier …
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Theoretical Studies of Protein-Protein Interactions
Proteins are known to play major roles in most processes taking place inside living cells. Understanding their functions and mechanisms of their action is one of the most important problems in the fields of biochemistry and biophysics. In this work we study a kinase called Extracellular Signal …
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Metal-protein interactions for proteomics applications
… biological mechanisms, the understanding of proteins and their functions is a vital component. However the complexity of the proteome poses an immense challenge for analytical chemists to explore it comprehensively. Currently mass spectrometry is at the forefront of proteome analysis, …
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Eukaryotic Transcriptional Activation Mechanism: Protein-Protein Interactions
… demonstrated to have physical and functional interactions with TBP and/or TFIIB. Given the central role of TBP in transcriptional regulation, I also identified distinct TBP domains (or residues) important for different regulatory interactions including those with acidic activators, TFIIB, Dr1 …
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DNA-Protein Interactions in f1 DNA Replication
… analyzes the interaction of two DNA-binding proteins with the plus strand replication origin of bacteriophage f1. The origin has a bipartite structure consisting of a required core origin region and an adjacent A+T- rich enhancer sequence that potentiates replication approximately 100-fold. …
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Computational prediction of human protein-protein interactions
… While identifying individual genes and their protein products is crucial, understanding how these entities exist within the context of other molecules within the cell provides valuable insight into their functional significance. In particular, mapping the intricate web of interactions between …
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Evolution and engineering of protein-protein interactions
Protein-protein interactions are crucial elements in most biological processes. The gain and loss of interactions during evolution have important phenotypic consequences that are subject to selection. Therefore, in a crowded cellular environment, proteins must evolve mechanisms to maintain the …
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Visualization, Kinetics, and Thermodynamics of DNA-Protein Interactions
… and structural information about DNA–protein interactions. Furthermore, the micrographs obtained by cryo-TEM were compared to AFM images taken in a previous work. The main goal of this work was to investigate the influence of surfaces on DNA–protein interactions, therefore the methods …
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STAT3-protein interactions in IL-6/gp130 signaling
… using gamma-Fibrinogen (ã-FBG), an acute phase protein, as a model. IL-6 induces a strong nuclear association of STAT3 with CDK9, which is mediated via both STAT’s NH2-terminal and COOH-terminal domains. The induction of ã-FBG by IL-6 is significantly decreased when CDK9 is repressed by kinase …
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Systems Biology of Host-Pathogen Protein-Protein Interactions
… parasite that co-opts host cellular proteins, often through protein-protein interactions (PPIs), to ensure its replication. Therefore, this thesis aims to integrate high-throughput proteomic approaches with computational modelling to systematically characterize SARS-CoV-2-human …
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Significance of Protein Interactions in Mediating AF9 Function
… MLL gene rearrangements give rise to chimeric proteins that contain the N-terminal portion of MLL fused to the C-terminal portion of over 50 different fusion partners. The chimeric proteins cause constitutive expression of some MLL target genes such as HOXA9 and MEIS1, and enhanced …
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Small molecule inhibition of immunoregulatory protein-protein interactions
Selective molecular recognition between proteins is a fundamental event in biological processes that governs cellular growth, function, survival, and differentiation. The immune system, for example, is a complex network of cellular processes regulated by protein-protein interactions (PPIs) between …
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Archaeal Basal Transcription Factors: DNA and Protein Interactions
… Transcription Factor B (TFB) and TATA-Binding Protein (TBP). After the first sequence analysis of an archaeal genome (Bult et al., 1996), transcription in Archaea became a more attractive territory to explore since there were no other clear homologs of basal transcription factors in the genome …
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DNA -Protein Interactions in the CTnDOT Excisive Intasome
… to date. Excision requires multiple accessory proteins. Exc is one protein required for excision, however, its function is unknown. In an attempt to determine a role for Exc, the native wild type Exc protein was purified. These studies indicated that Exc might interact with IntDOT during …
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Biochemical and Genetic Analyses of Rna-Protein Interactions
The coat protein from bacteriophage R17/MS2 functions to repress translation of replicase and functions to encapsidate the RNA genome of the phage. The coat protein accomplishes these functions by interacting with a 21 nucleotide stem-loop structure located within the translation initiation region …
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Study of correlation analysis for protein-protein interactions
Protein-protein interactions take place when two or more proteins bind together, usually to carry out some biological functions. Many biological processes are formed by interaction networks that are consisted of more than one protein-protein interaction. To understand the proteins’ function …
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Protein interactions in vitro and in the cell
… mg/mL bio-macromolecules. In this environment proteins are far from isolated systems and interact with many other biological molecules they encounter. In recent years, better instrumentation and greater computing power have enabled imaging of elusive biomolecule dynamics in cells, driving many …
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