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Showing 1 to 3 of 3 for “"Protein Interaction Domains and Motifs"”.
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Logic and Mechanism of an Evolutionarily Conserved Interaction in PDZ Domain
Proteins are beautiful materials evolved to channel specific energetic perturbations into particular functions. At the core of virtually every biological process are two features of a protein: the energetic architecture and the mechanisms of energy propagation. Structural, dynamics, and mutagenesis …
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Decomposition of Proteins into Functionally and Evolutionarily Independent Cooperative Units
Understanding cooperative interactions within proteins is an important goal because cooperativity underlies protein functions such as catalysis, allostery, ligand binding and folding. Cooperative units within proteins can be revealed via an evolution based method called statistical coupling …
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Evolutionary Constraints Specifying Protein Folding and Function
Proteins are complex macromolecules that carry out biological functions while under constant mutational load and selective pressure during evolution. Consequently, evolution has generated protein families by exploring the set of sequences able to carry out a particular biological activity, …