Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"Protein Delivery"”.
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Proliposome Technology for Protein Delivery
… potential of the respiratory tract for systemic delivery of macromolecules, particularly proteins and peptides. However, limitations such as short transit time and loss of activity of some proteins and peptides in the respiratory tract need to be overcome. Consequently, the utility of controlled …
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Uniform biodegradable microparticle systems for protein delivery
Therapeutic protein drugs are receiving increasing attention in pharmaceutical industry due to the fast development of biotechnology and genomics. Because of their low oral and transdermal bioavailabilities, fragility and short half-lives in vivo, novel and effective alternatives to deliver protein …
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Uniform double wall microspheres/microcapsules for protein delivery
… were heavily investigated for controlled delivery of small molecule drugs as well as proteins and DNA. The size distribution of protein-loaded biodegradable polymer microparticle is a crucial factor for allowable routes of administration. Also, the geometric structures of microparticles …
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Synthesis of biodegradable hydrogel microparticles for vaccine protein delivery
Soluble protein antigens used in vaccines have shown lower immune responses when compared with certain particulate forms of these same antigens. For example, it has been shown that micro- and nano-particle mediated delivery of protein antigen can use up to 100 times less protein and still produce …
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Catalase-loaded liposomal magnesium phosphate nanoparticles for intracellular protein delivery
<p>Proteins are large biomolecules that have great therapeutic potential in treating many human diseases. Proteins exert higher specificity and more complicated functions; they are well endured and less inclined to evoke immune responses when compared to small molecule drugs. However, exogenous …
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Optimizing chondrogenic factors and protein delivery methods for cartilage repair
… bovine and adult human BMSCs. HB-IGF-1, a fusion protein of the heparin binding domain of HB-EGF and IGF-1, can be retained in cartilage matrix and stimulate proteoglycan synthesis with a single dose, whereas unmodified IGF-1 easily diffuses out of cartilage tissue. The RAD peptide was used as a …
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Self-assembling polymeric nanoparticles for enhanced intra-articular anti-inflammatory protein delivery
… material to deliver anti-inflammatory protein for treating OA. Our central hypothesis for this work is that a controlled release/presentation system will more effectively deliver anti-inflammatory protein therapies to the OA joint. The primary goal of this work was to synthesize a block …
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A novel intracellular protein delivery system - Magnesium phosphate nanoparticles with cationic lipid coating for catalase intracellular delivery
<p>Protein therapeutics have great potential in treating human disease, especially for those caused by alternations in the functions of intracellular proteins. However, clinical use of protein by intracellular delivery has been hampered by the instability due to proteins' physicochemical …
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Development of preformed photo-crosslinked intravitreal implants for protein delivery to the posterior segment of the eye
… of the introduction of commercial therapeutic protein products. The treatment of disorders of the back of the eye, which are collectively referred to as 'posterior segment diseases of the eye,' is made possible by this group of proteins. These disorders include age-related macular degeneration …
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Biodegradable in situ forming photocrosslinked implants for sustained protein delivery to the posterior segment of the eye
Drug delivery to the posterior segment of the eye is a significant challenge, particularly in the context of sustained drug delivery for the treatment of chronic ocular conditions. The challenge is further increased due to the fact that the anti-VEGF agents, used to treat two of the most pertinent …
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Functional Protein Delivery Using Polymeric Nanoparticles: A Novel Therapeutic Approach to Alpha-Synuclein Aggregation and Parkinson's Disease
An efficient route for delivering specific proteins and peptides into neurons could greatly accelerate the development of therapies for various diseases, especially those involving intracellular defects such as Parkinson's disease (PD). Synthetic nanoparticles made from polybutylcyanoacrylate …
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A New Interfacial Cross Linking Technique: Preparation, Characterization and Evaluation of Calcium alginate Nanoparticles as a Protein Delivery System
… for site specific and/or time controlled delivery of small or large molecular weight drugs and other bioactive agents. The use of biopolymers as a natural carrier system not only makes the formulation easy but provides an additional advantage of being non toxic and easily degradable within …
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Synthesis, Characterization and In-vivo Testing of Photoactivatable Insulin Depots for Continuously Variable and Minimally Invasive Insulin Delivery
Proteins are macromolecules involved in a diverse array of functions. Mutations or abnormal levels of proteins are indicated in several diseases. Despite showing early promise, the translation of protein therapeutics into the clinics has been challenging. The stability of these macromolecules, …
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Development and evaluation of a beta-glucan biopolymer formulation of lactoferrin produced using a novel cryomilling technique
Transformation of therapeutic proteins from the new compound stage to a marketed product for clinical use depends on the development of an appropriate formulation, using technologies that avoid the underlying causes of protein degradation. Although synthetic biodegradable polymers have been …
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Nutrition in survivors of critical illness: an exploration of the effect of nutrition therapy on muscle mass, nutritional status and clinical outcomes after critical illness with a focus on patients with a traumatic brain injury
… cohorts of critically ill patients, nutrient delivery during ICU admission is below prescribed targets. From a large international cohort, I determined that energy and protein delivery to ICU patients with TBI is below targets, and deficits in the first 12 days are associated with longer time …
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Development of a cargo delivery system and inhibition studies focused on clostridium difficile toxin a
… exotoxins, disease arises from cytotoxic proteins, and cytotoxicity is acheived only after cell entry. This intrinsic mechanism for cell entry is intriguing from research and medical views. Along with a review on existing cargo delivery systems utilizing protein toxins and the usefulness …
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Development of an in-cell förster resonance energy transfer technique to study protein structure inside living cells
… fluorescence acceptors and donors within a protein or between two proteins inside the correct intracellular compartment of living cells. The successful achievement of this goal will allow us to obtain high-resolution structural information from a protein, one key step towards high-resolution …
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Targeted Gene Therapy Approaches for Huntington's Disease: Advancing Treatment through Bioengineered Self-Assembling Peptide Hydrogels and BDNF-Encoded Adeno-Associated Viruses, Applied In Vitro and In Vivo
… a single polyglutamine repeat in the huntingtin protein. It mainly enhances the loss of striatal neurons and primary cortical neurons within the forebrain. Gene therapy has provided promising targeted therapeutic strategies to treat various neurodegenerative disorders such as HD, where the …
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Targeted Gene Therapy Approaches for Huntington's Disease: Advancing Treatment through Bioengineered Self-Assembling Peptide Hydrogels and BDNF-Encoded Adeno-Associated Viruses, Applied In Vitro and In Vivo
… a single polyglutamine repeat in the huntingtin protein. It mainly enhances the loss of striatal neurons and primary cortical neurons within the forebrain. Gene therapy has provided promising targeted therapeutic strategies to treat various neurodegenerative disorders such as HD, where the …
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