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Showing 1 to 20 of 297 for “"Protein Complexes"”.
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Photovoltaic devices using photosynthetic protein complexes
Photosynthetic proteins have been used as an active material in design of organic solar cells. Traditional organic solar cells have the limitation of not being able to absorb light in the visible-NIR region of the solar spectrum. This region corresponds to over 70% power of the total solar …
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Investigating Potential Multi-Protein Complexes Involving Emx2
… its expanse, with one exception: a handful of proteins that regulate neocortical arealization are generated in gradients across the expanse of the neocortex and control the size of the future neocortical areas. The most highly characterized protein involved in this process is Emx2. Previous …
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Evolutionary Coupling in Multisubunit Membrane Protein Complexes
… the motifs that mediate interactions between proteins. The strategy for inferring interacting motifs is based on evolutionary correlation, which states that the patterns of mutations in two proteins that interact are correlated across a set of species. This dissertation makes three important …
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Photochemical harpoons: covalent labels for multi-protein complexes
… and may interact with a large number of cellular proteins. In this work phenyl saligenin phosphate has been synthesised and its inhibitory effect on the action of transglutaminase 2 (TGase2) demonstrated. Analogues of PSP containing an attached dansyl amide fluorescent group have been prepared and …
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Structural and functional characterization of signaling protein complexes
… improtant. Examples from two regulatory proteins, c-Cbl and calmodulin are presented. c-Cbl is an E3 ubiquitin ligase and a major regulator of tyrosine kinases. Through x-ray crystallography of five Cbl-TKB:phosphopeptide complexes, the mechanism by which the Cbl-TKB domain binds to its …
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SOLAR ENERGY HARVESTING WITH PHOTOSYNTHETIC PIGMENT-PROTEIN COMPLEXES
… to this process are the photosynthetic pigment-protein complexes that transduce sunlight into biologically useful forms of energy through a photochemical charge separation that has a quantum efficiency close to 100%. Integrating these natural pigment-protein complexes in bio-hybrid architectures …
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Identifying protein complexes and disease genes from biomolecular networks
… techniques, large-scale biological data, such as protein-protein interaction (PPI) data, gene expression data, gene-disease association data, cellular pathway data, and so on, have been and will continue to be produced. Those data contain insightful information for understanding the mechanisms of …
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Analysis of Human Protein Complexes by Quantitative Mass Spectrometry
Proteins are the fundamental building blocks of all living cells and they carry out nearly all cell functions. Proteins predominantly act as part of multiprotein complexes to carry out these functions. The association of protein isoforms and post-translationally modified forms in protein complexes …
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Probing cellular protein complexes using single-molecule pull-down
… limit: the analysis of single biomolecular complexes. We achieve this goal by performing the pull-downs directly on to the surface of microscope slides and visualizing the captured biomolecules at single-molecule resolution using total internal reflection fluorescence (TIRF) microscopy. We …
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Single molecule pull-down of viral RNA-protein complexes
Protein and RNA molecules interact with multiple protein partners to perform essential cellular processes such as post-transcriptional regulation of mRNA. Recently, a single molecule pull-down (SiMPull) assay was developed to isolate and study single protein complexes directly from cell lysates. …
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RNA recognition: controlling RNA-protein complexes with small molecules
… Interaction of Pathogenic RNAs with the MBNL1 Protein and Complex Inhibition by Small Molecules PART I. RNA plays important and versatile roles in gene expression by both carrying and regulating the information used to direct protein synthesis. Therefore, small molecules able to bind to RNA and …
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Elucidating the Biological Function of PWWP-Domain Containing Protein Complexes
In eukaryotes, nuclear DNA is folded with histone proteins in the form of chromatin, and this structure plays a critical role in multiple biological processes, including development, DNA damage repair, and aging. Post-translational modifications of histones, such as acetylation and methylation, are …
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Protein complexes and microclusters. Regulation of signaling nodes in T lymphocytes
Contains fulltext : 141383.pdf (Publisher’s version ) (Open Access)
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Characterization of Protein Complexes and Protein Interaction Networks by Mass Spectrometry
… experimental proteomics approach for deciphering protein complexes and protein interaction networks in the budding and fission yeasts. Key steps of the employed analytical routine, including the purification of complexes and mass spectrometric identification of their subunits, were investigated in …
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The Factors Influencing The Formation and Properties of Lipid-Protein Complexes
Made available in DSpace on 2014-12-05T19:06:44Z (GMT). No. of bitstreams: 1 0025260.pdf: 4290311 bytes, checksum: afebb5266831afe4b5cc6f64cc5effd0 (MD5) Previous issue date: 1957
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Solid-state NMR studies of membrane proteins and membrane protein complexes
Membrane proteins help control nearly every process in the cell, which is why approximately 50% of pharmaceuticals currently on the market target membrane proteins. Knowledge of structure-function relationships of these proteins could be leveraged to produce more efficient drugs. However, the …
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Simulation and visualization of dynamics in RNA-protein complexes in translation
… information and synthesizing the corresponding proteins, is universal and found throughout the three domains of life. The flow of information in translation involves a series of distinct but highly conserved RNA·protein complexes with the ribosome being the largest ribonucleoprotein complex in …
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Machine Learning Approaches for Identifying microRNA Targets and Conserved Protein Complexes
… of essential components in the cell, such as proteins, microRNAs, and genes. This dissertation focuses on two interesting problems in bioinformatics research: microRNA-target prediction and the identification of conserved protein complexes across species. We define the two problems and develop …
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