Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Protein Chaperones"”.
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Structural investigations of adenosylcobalamin-dependent enzyme maturation
… of these metallocofactors often relies on proteins known as metallochaperones that transport, modify, and/or insert the metallocofactor for its target metalloenzyme. This thesis focuses on the maturation of methylmalonyl-CoA mutase (MCM). In humans, MCM is the only known adenosylcobalamin …
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Assessing the role of Hsp70 in prion propagation in Saccharomyces cerevisiae
The term Prion (Proteinaceous infectious) was first described by Stanley Prusiner in 1982. Prions are infectious proteins and are responsible for many neurodegenerative diseases, collectively termed as transmissible spongioform encephalopathies, including; BSE, vBSE, scrapie and CJD. Prions are …
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Thiol-Based Misfolding: Linking Redox Balance to Cytosolic Proteostasis
… oxidants and xenobiotics. Cysteine-containing proteins are especially at risk as the thiol side chain is subject to oxidation, adduction and chelation by thiol-reactive compounds. All of these thiol-modifiers have been demonstrated to induce the heat shock response and recruit protein …
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Functional characterisation of aphid, Myzus persicae, nicotinic acetylcholine receptors and identification of a novel biogenic amine-gated ion channel from the honeybee, Apis mellifera
… crop species. The nAChR subunits and several protein chaperones from Myzus persicae have been cloned. It was difficult to achieve robust and frequent expression of a nAChR consisting entirely of subunits from Myzus persicae with the chaperones RIC-3, UNC-50 and TMX3. However, use of the α1 …
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THE ROLE OF HSF1 PROTEIN REGULATION ON NEURODEGENERATION
Cellular protein homeostasis is achieved by a delicate network of molecular chaperones and various proteolytic processes such as ubiquitin–proteasome system (UPS) to avoid a build-up of misfolded protein aggregates. The latter is a common denominator of neurodegeneration. Neurons are found to be …
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Regulation of The Heat Shock Response By Thiol-Reactive Compounds In The Yeast Saccharomyces Cerevisiae
… resulting in rapid synthesis of heat shock proteins (HSPs), which serve to protect cellular constituents from the deleterious effects of stress. In addition to its role in cytoprotection, the HSR also influences lifespan and is associated with a variety of human diseases including cancer, …
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Microglial activation and regulation by secreted chaperones
… and LRPAP-1 are ubiquitously expressed protein chaperones that aid in protein folding and processing within the endoplasmic reticulum (ER). Both proteins might also be released into the extracellular space, but, if so, it is unclear whether and how they affect microglial functions when …
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Structural and Functional Evolution of Human Heat Shock Transcription Factors
… the expression of numerous genes involved in protein folding, protein degradation, and cellular survival. The studies presented here utilize a diverse array of techniques including yeast genetics, recombinant protein expression and purification, biochemical analysis of protein-DNA …