Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Protein Carbonylation"”.
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Identification and Quantification of Protein Carbonylation by Mass Spectrometry
… modify a wide range of biomolecules including protein, DNA and carbohydrate. In this dissertation, we investigate the modification of two model proteins, human serum albumin (HSA) and aconitase (ACO), by the LPO-relevant a, b-unsaturated aldehydes, acrolein (ACR) and 4-hydroxy-2-nonenal (HNE). …
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Mass Spectroscopic Identification and Quantification of Protein Carbonyls
… diseases. Among the post-translational protein modifications, carbonylation has attracted a great deal of attention due to its irreversible and irreparable nature. Despite the fact that protein carbonylation is associated with a series of physiological and pathological processes, there …
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Direct selection on lifespan in Drosophila Melanogaster to elucidate the mechanisms of longevity
… in the selected lines, and neither did levels of protein carbonylation change, suggesting that early life prevention of oxidative damage is not an indicator of lifespan. Differential expression analysis of the long-lived flies revealed enrichment of developmental and metabolic biological processes …
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Mitophagy in Heart Failure: A Selective Autophagic Degradation of Mitochondria
… process through which cytoplasmic proteins and organelles can be degraded and has recently been shown to participate in remodeling of the myocardium in a variety of cardiac pathologies. Autophagy can be either non-selective or selective for damaged protein aggregates or organelles. …
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Investigating the molecular biology of aging and extended longevity: Proteomic and genomic analysis of mouse liver
… aging and oxidative damage to ER resident proteins, which exist in a strongly oxidizing environment necessary for disulfide bond formation. In these studies, young and aged mouse liver homogenates were separated into enriched sub-cellular fractions, and the ER/mitochondrial fraction was …
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Excessive iron accumulation mediated oxidative stress and β-cell dysfunction via perturbations of insulin secretion in MIN6 cells
… mitochondrial membrane potential (Δψm), and protein carbonylation were estimated. In addition, antioxidant activity (cellular/non-cellular), cytotoxicity, and cellular ferritin were assessed using the shell of nanocarriers composed of (i) potato protein (PP) - potato dextrin (PD), (ii) PP - …
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Proteomics of Oxidative Stress Using Inducible CYP2E1 Expressing HepG2 Cells and 3T3-L1 Adipocytes as Model Systems
… based identification. We found citric acid cycle proteins such as pyruvate carboxylase, citrate synthase, as well as beta-oxidation enzymes; cartinine acyl transferase and long-chain enoyl-CoA hydratase up-regulated from 7 through 18 days post differentiation onset. These data indicate TCA …
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The physiological response of the white-rot fungus, Schizophyllum commune to Trichoderma Viride, during interspecific mycelial combat
… the expression patterns of metabolites, proteins and selected genes of Schizophyllum commune in response to the antagonist. The study also investigated the implication of oxidative damage in these response patterns. Microscopic examination of stained and unstained mycelia of S. commune …
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Biomarkers of oxidative stress in models of schizophrenia.
… acids in affording protection to cellular DNA, protein and lipids from an oxidative challenge. In addition, two human studies were undertaken. The first study utilised the non-invasive technique of breath hydrocarbon analysis. The lipid peroxidation products were compared between a population of …