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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 82 for “"Protein C"”.

  1. Expression of Human Protein C in Transgenic Tobacco

    Ni, Hao IIVirginia Tech1997

    Human Protein C (hPC) is a vitamin K-dependent serine protease that has a critical role in the naturally-occurring anticoagulant pathway. Upon activation of the zymogen by thrombin at the endothelial cell surface, the active form of hPC has anticoagulant activity in hemostasis due to its ability to …

    vt Repository record

  2. Identification and characterisation of novel interactors of surfactant protein C

    Ying, HaoyangUniversity of Cambridge2023

    Inherited pathogenic variants of surfactant protein C (SFTPC) can cause familial pulmonary fibrosis. The most common, SFTPC-I73T, aberrantly localises to the plasma membrane and causes alveolar type 2 (AT2) dysfunction via a poorly understood toxic gain-of-function. Understanding the mechanisms of …

    cambridge Repository record

  3. Potential sources for the large scale production of human protein C

    Morcol, TulinVirginia Tech1992

    The vitamin K-dependent family of proteins (VKDs) include prothrombin, factors VII, IX, and X, and protein C (hPC) is synthesized in the liver and act to maintains normal hemostasis. such as properly regulated clotting. An imbalance of any of these pro- or anti-clotting proteins result in …

    vt Repository record

  4. Einfluss von humanem rekombinantem aktivierten Protein C auf die monozytäre Antigenrepräsentation in vitro

    Steinkrüger, Silvia Katharina2011

    aachen Repository record

  5. Haploinsufficiency of Cardiac Myosin Binding Protein-C in the Development of Hypertrophic Cardiomyopathy

    Barefield, David2016

    … and sarcomere disarray. Mutations in sarcomeric protein encoding genes have been established as causative for HCM.</p><p>The gene MYBPC3, encoding cardiac myosin binding protein-C (cMyBP-C), is the second most commonly mutated gene in HCM cases. As a majority of these mutations have been …

    loyola-thes Repository record

  6. Analysis of the role of outer surface protein C (OspC) in Borrelia burgdorferi pathogenesis

    Rhodes, DeLacy2021

    … cycle is through the expression of outer surface protein C (OspC). OspC is a surface exposed lipoprotein encoded on circular plasmid 26 that forms homodimers on the bacterial surface and has distinct conserved and variable portions of sequence. When ospC is deleted, the spirochetes are unable to …

    vcu Repository record

  7. Arterial Thrombosis in Factor V Leiden or Activated Protein C Resistance. Clinical and Experimental Studies.

    Sampram, EllisClinical Coagulation Research Unit, Clinical Science, Malmö.2012

    … an avalanche of studies establishing Activated protein C (APC) resistance due to Factor V Leiden mutation as the most prevalent genetic risk factor, yet known, for venous thromboembolism. This has been documented in 20-60% of patients with deep vein thrombosis (DVT). Whether such propensity also …

    lund Repository record

  8. Modifikation des Hypertrophie-Phänotyps der Myosin-Bindungs-Protein-C defizienten Maus durch Muscle-LIM-Protein

    Braach, Martin2012

    … des Hypertrophie-Phänotyps der Myosin-Bindungs-Protein-C defizienten Maus durch Muscle-LIM-Protein Von einer Herzinsuffizienz sind etwa 3 % der Menschen in den alten Bundesländern betroffen. Ursächlich liegt oft eine genetische Veränderung in Funktionsproteinen vor, zu denen das …

    goettingen Repository record

  9. Hypertrophe Kardiomyopathie hervorgerufen durch eine Mutation im Myosin bindenden Protein C in einer großen deutschen Familie

    Ochs, Julia Katharina2009

    aachen Repository record

  10. Improvement of expression of recombinant human protein C in the milk of transgenic animals using a novel transgene construct

    Russell, Christopher G.Virginia Tech1993

    … of transgenes using the murine whey acidic protein (WAP) promoter have shown widely variable, position-dependent and copy number-dependent expression. This study evaluates a series of three WAP transgenes containing the cDNA of human protein C (hPC) for the expression of human protein C in …

    vt Repository record

  11. Das Akute-Phase-Protein C-reaktives-Protein als Monitoring bei Patienten mit Urolithiasis während einer Behandlung mittels extrakorporaler Stoßwellenlithotripsie (ESWL)

    Krämer, Ulrich1995

    aachen Repository record

  12. Wertigkeit von NT-proBNP, Surfactant Protein-B und Surfactant Protein-C als Marker zur Differentialdiagnose bei Patienten mit akuter Dyspnoe

    Schaumberg, Jens2012

    … finden die lungenepithelspezifischen Surfactant-Proteine B (SP-B) und D (SP-D) als diagnostische Parameter Eingang in die weitere Abklärung einer Dyspnoe. Ziel dieser Untersuchung war es, die differentialdiagnostische Wertigkeit von NT-proBNP (N-terminales Spaltprodukt des brain natriuretic …

    goettingen Repository record

  13. Präpartale Veränderungen in der Aktivität des Protein C und im Verhalten des gesamten und freien Protein S bei Schwangerschafts-induzierter Hypertonie und Präeklampsie

    Buchta, Therese1998

    aachen Repository record

  14. A Molecular Genetic Investigation of the Regulation of Outer Surface Protein C in Borrelia Burgdorferi: Identification and Characterization of the Novel Regulatory Protein BBD18

    Hayes, Beth2014

    … and subsequently alter their gene expression and protein profiles. As part of this adaptation, spirochetes within the tick midgut downregulate outer surface protein (Osp) A and upregulate OspC. Although OspC is an essential B. burgdorferi virulence factor needed for early mammalian infection, it …

    montana-tech Repository record

  15. A Molecular Genetic Investigation of the Regulation of Outer Surface Protein C in Borrelia Burgdorferi: Identification and Characterization of the Novel Regulatory Protein BBD18

    Hayes, Beth2014

    … and subsequently alter their gene expression and protein profiles. As part of this adaptation, spirochetes within the tick midgut downregulate outer surface protein (Osp) A and upregulate OspC. Although OspC is an essential B. burgdorferi virulence factor needed for early mammalian infection, it …

    montana Repository record

  16. Development of Methods for Measuring Protein C Inhibitor and Antithrombin: Use of Monoclonal Antibodies against the Reactive Center Loop-Inserted Forms of the Serpins

    Kjellberg, MargaretaDepartment of Laboratory Medicine, Lund University2007

    Protein C inhibitor (PCI) and antithrombin (AT) are serine protease inhibitors (serpins) that are involved in the regulation of coagulation. Like other inhibitory serpins, PCI and AT adopt different structural conformations that are related to their functions. The cleaved, inactive form is a result …

    lund Repository record

  17. Signifikante Assoziation zwischen der Prävalenz der Resistenz gegen aktiviertes Protein C infolge Faktor V Leiden und Myokardinfarkt: Studie mit 507 Myokardinfarktpatienten und Metaanalyse früherer Publikationen

    Middendorf, KatharinaLudwig-Maximilians-Universität

    lmu-germany Repository record

  18. Upstream and downstream issues in the production of recombinant vitamin K-dependent proteins in the milk of transgenic pigs

    Van Cott, Kevin E.Virginia Tech1996

    … safety concerns for plasma-derived therapeutic proteins, such as protein C and Factor IX, have spurred the development of recombinant DNA technology for large-scale, economically feasible production of therapeutic proteins. The mammary gland is unique in its ability to synthesize and secrete …

    vt Repository record

  19. Erstellung und Erprobung eines wissensbasierten Systems zur Unterstützung der Labordiagnostik der Thrombophilie

    Schmalz, Markus Oliver

    … Quick, aktivierte partielle Thromboplastinzeit, Protein C, Protein S, Resistenz gegen akt. Protein C (APCR), Faktor V-Mutation, Faktor II-Mutation, Lupus Antikoagulans, Cardiolipin-Antikörper und Heparin assoziierte Antikörper werden von der WB berücksichtigt.<br><br>Besonderen Wert bei dem …

    freiburg-diss Repository record

  20. Hypertrophic Cardiomyopathy: A Review of Clinical and Molecular Characteristics and Effects and A Clinical Case Study

    Freitas, Natalie E.University of Nevada, Reno2014

    … young athletes. Mutations of the myosin-binding protein C (cMyBP-C) have been targeted as one of the most prevalent causes of this disease, and the deactivating effects of such mutant forms on the quality control ubiquitin-proteasome system (UPS) contribute to cardiac dysfunction. The E334K …

    unr Repository record

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