Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"Protein B"”.
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Transferrin binding protein B structure, function, and export in Neisseria gonorrhoeae
… is sequestered in the host by iron-binding proteins, such as lactoferrin and transferrin. Neisseria gonorrhoeae utilizes transferrin as an iron source and its iron acquisition system is composed of two transferrin binding proteins: TbpA and TbpB. TbpA is a TonB-dependent, outer membrane …
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Investigating the effect of amyotrophic lateral sclerosis-associated mutant vesicle-associated membrane protein B on axonal transport
… them dependent upon the proper transport of protein and organelle cargoes, especially through axons (axonal transport). Indeed, disruption to axonal transport is a very early, pathological event in ALS. A proline to serine substitution at position 56 in the vesicle-associated membrane …
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Wertigkeit von NT-proBNP, Surfactant Protein-B und Surfactant Protein-C als Marker zur Differentialdiagnose bei Patienten mit akuter Dyspnoe
… finden die lungenepithelspezifischen Surfactant-Proteine B (SP-B) und D (SP-D) als diagnostische Parameter Eingang in die weitere Abklärung einer Dyspnoe. Ziel dieser Untersuchung war es, die differentialdiagnostische Wertigkeit von NT-proBNP (N-terminales Spaltprodukt des brain natriuretic …
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Molecular genetics and microbiology of bioremediation using methane-oxidising bacteria
… hydroxylase (αβγ)2, regulator/coupling protein (protein B), and reductase. The hydroxylase contains the diiron active site. The three components of sMMO are found to be indispensable for full enzyme activity. In the present study, the sMMO hydroxylase was purified by anion exchange …
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Attempted Synthesis of a Photoreactive Geranylcysteine Derivative.
… to be studied as a mimic for farnesylated protein, <b>B</b>, the following syntheses were carried out. The hydroxyl group of geraniol was protected with DHP/PPTs to generate <b>1</b> (98.1%). Allylic oxidation of <b>1</b> by using TBHP/SeO2 yielded <b>2</b> (31.5%). A modified oxidation …
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The cellular degradation of the low density lipoprotein receptor and its ligand
The cellular degradation of the low density lipoprotein (LDL) receptor, and its ligand, LDL, were investigated in order to clarify certain mechanistic aspects of these important processes. Long-term lymphoblastoid cell lines and cultured human skin fibroblasts were used to examine the fate of …
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T Cell Intrinsic BCAP Links IL1R to the PI3K-mTOR Pathway and Regulates Pathogenic Th17 Differentiation
… homology (TIR) domains are found within adaptor proteins involved in the signaling of Toll like receptors (TLRs) and Interleukin 1 receptor (IL1R) families. Previous work by our lab identified a TIR domain in the protein B cell adaptor for phosphoinositide 3-kinase (BCAP) and determined a role …
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EFFECTS OF DAPAGLIFLOZIN ON EXERCISE CAPACITY, RESPIRATORY FUNCTION, BIOMARKERS, SLEEP APNEA, AND LEFT VENTRICULAR REMODELING IN PATIENTS WITH HEART FAILURE: A PROSPECTIVE, SINGLE CENTER, NON RANDOMIZED STUDY
… membrane function through surfactant protein-B (proSP-B), gas exchange, and sleep-disordered breathing. Evaluations were performed at baseline, 2–4 weeks, and after 6 months of treatment with dapagliflozin 10 mg/day. Results: Among 75 patients enrolled, 67 completed full follow-up. …
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Structural studies of trans-translation
Ribosomes translate messenger RNA (mRNA) into protein in all living cells. The faultless production of protein is critical for a vast array of catalytic and structural roles and is essential for the survival of the cell. Ribosomes themselves are made up of both RNA and protein, and are composed of …
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Interaction between DVAP, the orthologue of human VAPB, and Drosophila Sac1
… onset. Mutations in human (VAMP)-associated protein B (hVAPB) gene cause ALS8. Interestingly, the Drosophila VAPB (DVAP) is required at the Drosophila larval neuromuscular junction (NMJ), to control bouton morphology. In Pennetta’s lab Drosophila Sac1, a phosphoinositide-4- phosphate (PI4P) …
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Exploring the potential for biomarkers to aid forensic diagnosis of traumatic brain injury (TBI) – a systematic literature review and meta-analysis
… Biomarkers could offer potential insight. Proteins involved in neuroinflammation, such as systemic inflammatory biomarkers interleukin (IL)-1β, IL-6, and IL-10 and astroglia-associated biomarkers S100 Calcium-Binding Protein B (S100β) and Glial Fibrillary Acidic Protein (GFAP), have been …
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Metabolic and mechanistic exploration of a novel programmable genotoxicant against prostate cancer
… The new compounds are designed to utilize proteins such as steroid receptors that are abnormally expressed in cancers to enhance toxicity and specificity. The synthetic phase of this project successfully produced a compound, 11P, that when tested against cancer cell lines demonstrated …
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Effects of Preovulatory Estradiol Concentration on Embryo Survival and Pregnancy Establishment in Beef Cows
… on d 17, 19, 21, and 28 and pregnancy-specific protein B (PSPB) was used as a marker for pregnancy on d 22-28. Transrectal ultrasonography was used on d 29 to diagnose pregnancy. When ISG expression was used to predict pregnancy on d 17, 19, and 21, there was no difference between treatments. …
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Supplemental Trace Minerals (Zn, Cu, and Mn) as Sulfates or Hydroxy Trace Mineral Sources for Beef Heifers
… confirmed by the presence of Pregnancy-Specific Protein B concentrations in blood. No treatment differences (P ≥ 0.52) were detected in BW or ADG. There was no significance for greater mineral disappearance between mineral sulfate and hydroxychloride treatments (P = 0.46) There were no …
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Effects of mid-gestational L-citrulline supplementation to twin-bearing ewes on umbilical blood flow, placental development, and lamb production traits
… levels of progesterone and pregnancy-specific protein B (PSPB) were used as indicators of placental function and were unaffected by treatment administration (P>0.05). A treatment by time interaction was detected in both analyses, but no differences between treatments were detected within any …
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VOLTAGE GATED SODIUM CHANNEL AND NEURONAL DIFFERENTIATION. IMPLICATIONS IN AMYOTROPHIC LATERAL SCLEROSIS PATHOGENESIS
… gated sodium channels (VGSCs) are multimeric protein complexes formed by one alpha subunit, responsible of pore formation and of the regulation of the state of the channel, and by one or two accessory beta subunits that have an important role in the regulation of alpha subunit localization and …
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The effect of weight loss on circulating biomarkers of brain health and executive function
… neurotrophic fact (BDNF), S100 calcium binding protein B (S100B), and glial fibrillary acidic protein (GFAP). Serum samples (n=21; 50-75 years, BMI 25-40 kg/m2) were pooled from two prior weight loss studies. Fasting blood measurements were taken before and after 8- or 12-weeks of hypocaloric …
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Determining the role of nerve growth factor-beta in seminal plasma on bovine reproduction
Nerve growth factor-β (NGF) is a protein found in the seminal plasma of a variety of mammalian species. While initially known for regulating neuronal survival and differentiation, it was later discovered to interact within the endocrine and reproductive systems as well. Most notable is its function …
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Structural constraints for the folding, stability and function of cytochrome C
… was studied through the investigation of mutant proteins. Two isozymes of cyto-chrome c can be isolated from yeast, iso-1 and iso-2-cytochrome c. The structure of iso-l-cyto-chrome c had been previously determined in this laboratory using X-ray diffraction analyses. In the first part of this …
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