Global ETD Search
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Showing 1 to 9 of 9 for “"Protein Arginine Methyltransferase 1"”.
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Kinetic Characterization, Inhibition, and Activity-Based Protein Profiling of Protein Arginine Methyltransferase 1
<p>Protein arginine methyltransferases (PRMTs) are SAM-dependent enzymes that catalyze the mono- and di-methylation of peptidyl arginine residues. Although all PRMTs produce mono-methyl arginine (MMA), type I PRMTs go on to form asymmetrically dimethylated arginine (ADMA), while type II enzymes …
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Quasivirus Infection Model Identifies a Novel Role for Protein Arginine Methyltransferase 1 in the HPV Lifecycle
… like particles containing only the L1 capsid protein and they induce humoral immunity to HPV virions. The current form of this vaccine covers the seven most common oncogenic HPV types (HPV16, HPV18, HPV31, HPV33, HPV45, HPV52, HPV58) and the two genital wart HPV types (HPV6, HPV11). …
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The Design, Synthesis and in vitro Evaluation of Proteolysis Targeting Chimeras (PROTACs) for the Degradation of Protein Arginine Methyltransferase 1
Protein arginine methyltransferase 1 (PRMT1) is a protein responsible for the asymmetric dimethylation of arginine. PRMT1 is upregulated in a wide range of cancers and the reduction of PRMT1 activity reduces cell proliferation and tumour growth in cell and animal models of cancer. A reduction in …
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Methylation of Egfr By Arginine Methyltransferase Prmt1 Enhances Egfr Signaling and Cetuximab Resistance
<p>Protein modifications of epidermal growth factor receptor (EGFR) intracellular domain are well known regulators of EGFR functions whereas those of its extracellular domain remain relatively unexplored. Here, we report that methylation at R198 and R200 of EGFR extracellular domain by protein …
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Bead Based Peptidyl Libraries for the Selective Recognition of Glycoproteins, Differentiation of Carcinogenic Cell Types, and Determination of Enzyme Substrate Specificity
… of integral cell membrane and secreted glycoproteins is a hallmark of carcinogenesis and presents a unique opportunity to detect cancer at its earliest stages, when it is most treatable. Work towards developing boronic acid functionalized bead based peptidyl synthetic lectins (SLs) for the …
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Investigating The Role of Prmt1 and Arginine Methylation of Hsp70 In Human Pancreatic Cancer
<p>Protein arginine methyltransferase 1 (PRMT1) is the major arginine methyltransferase, which catalyzes the addition of one or two methyl groups to the arginine residues of its substrate proteins. The best-known substrate for PRMT1 is histone, while more and more non-histone proteins are now found …
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The Mammalian Hypoxia Response Pathway: Regulation of HIF and HIF Prolyl Hydroxylases
… HIF Prolyl Hydroxylase 2 (HPH-2) and focused on protein-protein interactions expecting that some of the interacting proteins might regulate its function. We characterized the function of a HPH-2 interacting protein identified in yeast two-hybrid screen; Inhibitor of Growth 4 (ING4) -a candidate …