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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 90 for “"Protein Adsorption"”.
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Protein adsorption on nanostructured silica surfaces
… presents a study of the interaction of globular proteins with nanostructured silica surfaces. It aims to gain a better understanding of the consequences of a high surface curvature and confinement on the adsorption behavior and morphology of the adsorbed protein. The adsorption behavior of …
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The wettability of biomaterials determines the protein adsorption and the cellular responses
… after exposure of biomaterials to blood, is the adsorption of blood proteins. Surface physicochemical properties of the materials as wettability greatly influence the amount and conformational changes of adsorbed proteins. In turn the type, amount and conformational state of the adsorbed protein …
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Poly (N-isopropyl acrylamide) brush topography: relationship to film collapse and protein adsorption
Made available in DSpace on 2013-02-03T19:18:31Z (GMT). No. of bitstreams: 2 Byung-Chan_Choi.pdf: 1830922 bytes, checksum: 742937613b4c5a0c78c70ef10e902f1a (MD5) license.txt: 4064 bytes, checksum: 53cdea897122dbf51517ac552aeb19e9 (MD5)
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Linear and star-shaped poly(ethylene oxide) grafted surfaces : grafting density and protein adsorption
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1996.
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Self-Assembly of Matching Molecular Weight Linear and Star-Shaped Polyethylene glycol Molecules for Protein Adsorption Resistance
… Traditionally, the factors believed to result in protein adsorption resistance have included i) steric exclusion arising from the compression of longer chains and ii) grafting density contribution which may provide shielding from the underlying material. Recent studies have suggested that PEG …
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Control of protein adsorption, cell morphology and intracellular signal transduction using self-assembled monolayers of alkylthiolates on gold
… of alkylthiol chemistries were used to monitor protein adsorption and subsequent Swiss 3T3 fibroblast adhesion, spreading and growth. Distinct alkylthiol substrate chemistry-dependent differences were observed. Formation of focal contacts and stress fibers, early indicators of effective …
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Improving Biocompatibility By Controlling Protein Adsorption: Modification And Design Of Biomaterials Using Poly(Ethylene Glycol) Microgels And Microspheres
… responses are initially elicited and directed by proteins that adsorb from this multicomponent solution to form thin films on their surfaces. The identity, conformation, and quantity of adsorbed proteins are related to the properties of a material's surface. For example, hydrophobic surfaces tend …
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Engineering poly(ethylene glycol) nanogel coatings: Developments in achieving ultralow protein adsorption and applications as substrates for stem cell culture
… interface with its biological environment. Proteins irreversibly adsorb to these interfaces within seconds to minutes of exposure, altering their structural conformation, inducing cell adhesion, and activating various cellular responses. To this end, surface modification strategies have been …
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Evaluation of monolayer protected metal nanoparticle technology
… metal nanoparticles are capable of resisting protein adsorption, and if utilized as a coating could have broad application in a wide range of industries from consumer products to maritime shipping to medical instruments. The formation of proteic films can adversely affect the performance of …
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Tending towards Non-fouling: A study of the interaction between proteins and surfaces prepared by radio frequency glow-discharge plasma
All proteins adsorb irreversibly onto surfaces and often results in denaturation, aggregation and loss of activity. This has serious implications not only for medical devices that are used clinically for the treatment of disease but also for the pharmaceutical industry that deals with handling, …
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Mechanistic Study of the Adsorption and Desorption of Proteins on Silica
Proteins are complex biomacromolecules that are intrinsically surface-active. Through the process of protein adsorption, the surface can act as a catalyst to facilitate dramatic structural alteration and destabilization of the protein. Understanding the mechanisms governing protein adsorption to a …
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Electrostatic Self-Assembly of Biocompatible Thin Films
… The ESA process is based on the alternating adsorption of molecular layers of oppositely charged polymers/nanoparticles, and can be applied in the fabrication of well-organized multilayer thin films possessing various biocompatible properties. ESA multilayer assemblies incorporating various …
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Nanotexturing for Biomedical Implants
… were analyzed with ImageJ analysis. Finally, protein adsorption on the Arbomatrix polymer films and electrospun nanofibers was completed. It was shown the protein adsorption on the nanofiber mats to be twice the amount on the films. The protein adsorption to the Arbomatrix film was less than …
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Developing Low Fouling Peptides and Zwitterionic Materials for Biomedical Applications
… designed from the examination of human protein surfaces found in nature. The peptide sequences glutamic acid/lysine (EK) and asparagine (N) were identified as displaying resistance to nonspecific protein adsorption. The low fouling sequence EK was further applied to several biomedical …
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Electrospinning polyampholyte nanofiber membranes
… REQUEST.] The elimination of nonspecific protein adsorption is an important challenge in many biomaterial applications. To address this issue, numerous nonfouling chemistries have been investigated. [2-(acryloyloxy) ethyl] trimethyl ammonium chloride (TMA) and 2-carboxy ethylacrylate (CAA) …
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Interactions between molecules and nanostructures using quartz crystal microbalance
The understanding of protein behaviour at the nanoscale is critical for the development of new therapies and biosensing. The assembly of peptides for new therapies are performed on the surface of a biosensor and because of the rough nature of this sample, the characterisation is usually performed …
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Biosynthesis of polyhydroxyalkanoates, their novel blends and composites for biomedical applications
… surface roughness and hydrophilicity affects protein adsorption on the surface of the biomaterial. Protein adsorption, in turn, plays an important role in determining the biocompatibility of a material being used for medical applications (Das et al., 2007). In this study, protein adsorption …
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Advancing fast relaxation imaging to determine protein stability and folding kinetics on poly(n-isopropyl acrylamide) films
… polymer PNIPAM to capture and release cells or proteins for medical purposes; however, this assumes that PNIPAM does not perturb the stability of biomolecules. Previous analytical and spectroscopic techniques have not been able to confirm this assumption due to limitations in detection of …
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Modelling and Multi-objective Optimization of Continuous Protein Recovery in Liquid-Solid Circulating Fluidized Bed (LSCFB)
… optimization of LSCFB system for continuous protein recovery process. A mathematical model was developed considering the protein adsorption and desorption characteristics, liquid-solid mass transfer and the hydrodynamics of the LSCFB, to predict the protein adsorption and desorption …
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Vertically-aligned carbon nanotube membranes for water desalination and ultrafiltration
… The membranes were tested for static and dynamic protein fouling. Bovine Serum Albumin (BSA) was used as a protein source. The static and dynamic protein adsorption experiments at neutral pH did not show any effect on prepared membranes. For static BSA test, Experimental results showed 32 μg/cm2 …
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