Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22075 for “"Protein"”.
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Protein-protein interaction between multi-functional protein CAD and protein phosphastase 1 (PP1)
… with activation of CAD, a multifunctional protein that catalyzes the first three steps in pyrimidine biosynthesis. The cell cycle dependent regulation of pyrimidine biosynthesis is a consequence of sequential phosphorylation of CAD Thr-456 and Ser-1406 by the MAP kinase and PKA cascades, …
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Protein kinases: Structure modeling, inhibition, and protein-protein interactions
<p>Human protein kinases belong to a large and diverse enzyme family that contains more than 500 members. Deregulation of protein kinases is associated with many disorders, and this is why protein kinases are attractive targets for drug discovery. Due to the high conservation of the ATP binding …
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Computational modeling of protein-protein and protein-peptide interactions
Protein-protein and protein-peptide interactions play a central role in various aspects of the structural and functional organization of the cell. While the most complete structural characterization is provided by X-ray crystallography, many biological interactions occur in complexes that will not …
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Protein-Protein Interaction Network Alignment
Proteins are some of the building blocks of organisms. They usually perform their functions by interacting with each other and forming protein complexes. A protein -protein interaction network is a graph that consists of proteins as vertices and their interactions as edges. Protein-protein …
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Human protein-protein interaction prediction
Protein-protein interactions are essential for the survival of all living cells, allowing for processes such as cell signalling, metabolism and cell division to occur. Yet in humans there are only >38k annotated interactions of an interactome estimated to range between 150k to 600k interactions and …
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K-Ras4B: Investigation of Protein-protein and Protein-phospholipid Interactions.
K-Ras4B: Investigation of Protein-protein and Protein-phospholipid Interactions.
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Theoretical Studies of Protein-Protein Interactions
Proteins are known to play major roles in most processes taking place inside living cells. Understanding their functions and mechanisms of their action is one of the most important problems in the fields of biochemistry and biophysics. In this work we study a kinase called Extracellular Signal …
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New reporters of protein trafficking and protein-protein interactions in live cells
… to harness the exquisite specificity of natural protein and RNA enzymes to develop improved methods to study protein localization and protein-protein interactions in live cells. We first attempted to detect endogenous protein-protein interactions (PPIs) in live cells by means of a ribozyme …
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Eukaryotic Transcriptional Activation Mechanism: Protein-Protein Interactions
<p>Various in vivo and in vitro assays have been employed to analyze how activators communicate with the general transcription machinery to stimulate transcription. As a first step, I analyzed the function of distinct kinds of activation domains in yeast and human. The results showed that the …
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Targeting the p53/MDM2 protein-protein interaction
The p53/MDM2 protein-protein interaction is the most widely characterised proteinprotein interaction to date. As of 2014, there are over 20 compounds that have been shown to the p53-MDM2 protein-protein interaction, however many compounds have not progressed into clinical trials due to their high …
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Computational prediction of human protein-protein interactions
… While identifying individual genes and their protein products is crucial, understanding how these entities exist within the context of other molecules within the cell provides valuable insight into their functional significance. In particular, mapping the intricate web of interactions between …
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Evolution and engineering of protein-protein interactions
Protein-protein interactions are crucial elements in most biological processes. The gain and loss of interactions during evolution have important phenotypic consequences that are subject to selection. Therefore, in a crowded cellular environment, proteins must evolve mechanisms to maintain the …
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Protein phosphatases and protein kinases in dictyostelium
… behavior and partial characterization of 5 protein phosphatases, 6 paranitrophenyl phosphate (pnpp) phosphatases and 2 protein kinases from <i>Dictyostelium</i> are described. .Two of the protein phosphatases are shown to have subunit structures. All of the protein phosphatase activities …
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Biophysical approaches to characterising protein-protein interactions and intermediate species in protein aggregation
The phenomenon of protein misfolding and aggregation has been associated with over 50 human diseases, including Parkinson’s disease (PD). While the hallmark deposits in aggregation-associated diseases are primarily composed of fibrillar species, intermediate oligomeric species that form during the …
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Protein-Protein Interaction and Structure-Function Studies of XcpR, a Protein Involved in Extracellular Protein Secretion of Pseudomonas Aeruginosa
… and toxins. The extracellular secretion of these proteins requires at least eleven xcp gene products (XcpP-Z) and the bifunctional peptidase/methylase, PilD. Although a number of macromolecular translocation mechanisms have been found in a wide range of bacterial species that involve xcp-related …
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Application of hydrogen deuterium exchange mass spectrometry in protein-ligand and protein-protein interactions
Proteins are not static objects. They have a great variety of internal motions with different amplitudes and different timescales. These internal motions play an important role in catalytic processes. Therefore, the existence of an intimate relationship between protein dynamics and protein function …
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Towards a comprehensive human protein-protein interaction network
… approaches for obtaining large-scale protein interaction data coupled with powerful computational methods for combining these data sets and for predicting functional relations between genes have been successful in tackling the yeast interactome. The concerted development of …
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Systems Biology of Host-Pathogen Protein-Protein Interactions
… parasite that co-opts host cellular proteins, often through protein-protein interactions (PPIs), to ensure its replication. Therefore, this thesis aims to integrate high-throughput proteomic approaches with computational modelling to systematically characterize SARS-CoV-2-human …
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