Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 328 for “"Protective effect"”.
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The protective effect of α-lipoic acid in doxorubicin induced cardiotoxicity in rats.
This study examined the protective effects of α-lipoic acid in rats exposed to a cardiotoxic dose of the widely used chemotherapy agent doxorubicin. α-Lipoic acid significantly enhanced the survival of rats exposed to a lethal dose of doxorubicin (p<0.001). Morbidity was proportionally higher in …
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Protective effect of JAK3 inhibition on growth factor deprivation induced neural progenitor cell death
… of GFs such as EGF, bFGF. In the present study, effect of JAK3 inhibition was examined on GFs withdrawal induced death of cultured NECs from embryonicmice brain (E13.5 days). The GFs withdrawal decreased cell vibility in time-dependent manner, however treatment of JAK3 inhibitor (WHI-p131) …
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Protective effect of dietary antioxidants and plant extracts on acute inflammation and hepatotoxicity in vitro
… such antioxidants and therefore exhibit higher effects than a single antioxidant due to the synergistic effects produced between such antioxidants. However, in the last decade a number of epidemiological, animal and in vitro studies have suggested a protective and therapeutic potency of these …
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Protective Effect of Statin Use in the Progression of Dry to Exudative Age-Related Macular Degeneration
PURPOSE: Age-related macular degeneration (ARMD) is a leading cause of irreversible blindness in the industrialized world. Studies suggest that HMG CoA reductase inhibitors (statins) might slow the progression of dry ARMD to the exudative stage. We set out to determine if statin use reduces the …
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Factors affecting the protective effect provided by sand fly saliva immunization on the outcome of Leishmania infection
… system, leading to possible establishment of protective effect on the disease outcome. This effect is based on the delayed type hypersensitivity reaction to sand fly saliva which has been shown to peak about 48 hours after antigen encounter, leading to the more effective host immune response …
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The influence of maternal nicotine exposure on development lung as gas exchanger: the protective effect of copper
… study was thus to determine and quantify the effects of maternal nicotine exposure on the development of the fetal and neonatal rat lung as a gas exchanger and to establish whether copper supplementation will protect the lungs against these adverse effects of maternal nicotine exposure. The …
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Protective effect of Nicotinamide on High glucose (HG)/Palmitate (PA)-induced Glucolipotoxicity to INS-1 beta cells
… of this study is to determine which mechanism of protective effect of nicotinamide on high glucose/palmitate (HG/PA)―induced INS-1 beta cell death. Protective effect of NAM was due to its role as an anti-oxidant, NAD+ precursor, or inhibitor of NAD+-consuming enzyme. first, Anti-oxidant activity …
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Novel Synthetic Compound, KR-22332, has radio-protective effect through inhibition of Mitochondrial Dysfunction and ROS Generation
… of head and neck cancer. But the acute side effect of radiation, especially oral mucositis, is observed almost all patients. Several radio-protective agents are developed but there is no definite agent to prevent. We found novel synthetic compound …
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An investigation of the protective effect of alpha+-thalassaemia against severe Plasmodium falciparum amongst children in Kumasi, Ghana
… or older than 60 months and therefore the protective effect from severe malaria might not wane with age. The mechanism of protection from severe Plasmodium falciparum malaria is not clear, however the influence of microcytosis and hypochromasia on parasite density requires more research.
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Protective effect of TM-25659, known as TAZ activator, on high-fat diet-induced insulin resistance in C57BL/6J mice
… by GCN2 pathways in skeletal muscle cells 22 C. Effects of TM-25659 reduced insulin resistance and inflammation in skeletal muscle cells treated with or without FGF21 siRNA 27 D. TM-25659 prevented HF-diet induced obesity 31 E. TM-25659 restored the insulin signaling pathways in DIO mice skeletal …
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Glycemic control and pancreatic beta cells protective effect of a lanosteryl triterpene from Protorhus longifolia in hyperlipidemic and STZ-induced diabetic rats
… recommendations and some undesirable side effects of metformin, there is an increasing need for alternative therapy. Drugs that cannot only decrease postprandial hyperglycemia, but also maintain pancreatic beta cells integrity for optimal function, could be vital in the management of DM. …
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Chemokines as therapeutic targets in systematic inflammatory response syndrome
… of CCR1 by a small molecule CCR1 antagonist has protective effect against acute lung injury in animal models of acute pancreatitis and sepsis. Depletion of mast cells by compound 48/80 has also attenuated acute pancreatitis-associated lung injury and sepsis-associated lung injury by attenuating …
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Life's Simple 7 and Global- and Domain-Specific Cognitive Function in an Older Adult Population
… cognitive scores are evaluated based on marginal effects after adjustments for confounding variables. Baseline LS7 scores (0-14) were calculated using information on smoking habits, body mass index, habitual diet, blood pressure, non, physical activity, and hemoglobin a1c. Results were analyzed …
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The role of melatonin in red wine-induced cardioprotection
… exact components in red wine that confer this effect are unclear. Previous studies performed in our laboratory suggest that neither the well-known polyphenol resveratrol nor alcohol (12%) present in red wine contribute to the cardioprotective effect of red wine when administered chronically, on …
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Attività antiossidante dei capsinoidi in diversi modelli sperimentali di stress ossidativo.
… been underlined. Moreover the phenol showed a protective effect in VERO cells against the tBH-induced reduction of the main membrane lipids. The vanillyl nonanoate exerted in vivo an important protective effect on the plasma and kidney lipid fraction of rats in a model of oxidative stress …
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Lethatlity of and Elicitation of Protective Antibody by Vibrio parahaemolyticus ATTC 17803
… to 10<sup>-0.72</sup>.</p> <p>The elicitation of protective antibody by this bacterium in male New Zealand White rabbits was demonstrated by testing control, baseline, and hyperimmune rabbit sera for their protective effect against 2 LD<sub>50 </sub>of the bacterium administered intraperitoneally …
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