Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 65 for “"Protecting Groups"”.
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Development of nitrogen protecting groups and synthesis and complexation of bridged bis-tetraazamacrocycles
<p>The development of nitrogen-protecting groups that are orthogonal to the N-benzyl group for use in cross-bridged tetraazamacrocycles and the synthesis and complexation of bridged bis-tetraazamacrocycles are presented. The allyl, p-methoxybenzyl (PMB), and 2-naphthylmethyl (Nap) …
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The use of immobilised crown ethers as in-situ protecting groups for organic synthesis within flow reactors
… the selective reaction of another moiety. While protecting groups are used to remove the problem of the functional group incompatibility, they also raise other issues such as increasing the length of the synthetic pathway (by at least two steps – protection and deprotection), generally leading to …
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SYNTHESIS, CHARACTERIZATION AND EVALUATION OF BIOACTIVE MOLECULES LINKED TO PHOTOREMOVABLE PROTECTING GROUPS FOR SPATIO-TEMPORAL CONTROL OF THEIR ACTIVITY THROUGH PHOTOACTIVATION
… photodynamic therapy (PDT), and photoremovable protecting groups (PPGs) play important roles in pharmaceutical research. The focus of this doctoral research lies on PPGs: these are chromophores covalently linked to approved drugs or bioactive molecules at functional groups essential for their …
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Funktionalisierte Linker für Metallorganische Gerüstverbindungen, deren postsynthetische Modifikation und polar markierte Schutzgruppen für terminale Alkine
… and polarity or chemical addressable, functional groups. The side chains have a direct influence on the chemical interior of the cavities within the MOFs and in the case of accessible functional groups can be chemically transformed. For the exploration of the postsynthetic possibilities Zr-MOFs …
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Studies on Solid-Phase Peptide Synthesis: The Synthesis of Glucagon
… protection; (2) the use of t-butyl based protecting groups for side chains of the trifunctional amino acids; and (3) the use of E-alkoxybenzyl-alcohol-resin as a solid support. At each step of the synthesis the N<sup>α</sup>-Bpoc moiety was removed by treatment with 0.5% trifluoracetic …
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Synthesis of Deoxysugars through Manganese-promoted Redox Isomerization
… synthetic routes towards deoxysugars rely on protecting groups to achieve selective outcomes. Here we report a concise synthetic strategy to access a diverse set of 2- and 4-deoxysugars using a Mn-promoted redox isomerization step that avoids lengthy protecting group manipulations. We …
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A New Approach to Drug Delivery: Non- Peptidic, High Load Macrocyclic Alternatives to Cell Penetrating Peptides
… Synthesis of an analogue featuring guanidinium groups on the upper rim was achieved using carboxybenzyl (Cbz) protecting groups as a less labile alternative to butoxycarbonyl (Boc) groups. The syntheses of analogues with varied linkers for attachment of the dye are also presented. Biological …
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Photoelectrochemical array platform for genomic scale DNA synthesis
… for the photoelectrochemical cleavage of protecting groups during in situ DNA synthesis. Photoelectrochemically patterned microarrays of phosphoramidite dye were produced with spot sizes of 100 um. This technology holds the potential for lowest cost per base pair of DNA produced over …
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Development and application of bioorthogonal palladium- labile derivatives of cytotoxic pyrimidine analogues
… of a set of prodrugs masked with bioorthogonal protecting groups sensitive to activation by a catalysts-based “activating device”. Specifically, it describes the synthesis of palladium (Pd0) functionalized resins (the activating device) capable of activating cytotoxic pyrimidine analogue …
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Tetrazine-Triggered Bioorthogonal Decaging Reactions for Prodrug Activation
… drugs, decaging methods for other functional groups are required in order to develop a broadly applicable prodrug activation strategy that can be applied to a wider range of drugs and diseases. This thesis describes the application of the tetrazine-triggered IEDDA reaction to cleave protecting …
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Automated flow peptide synthesis
… glycopeptides, removal of orthogonal amine protecting groups, and click chemistry on the solid phase. At full capacity, this approach to peptide synthesis can yield tens of thousands of individual 30-mer peptides per year.
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Optimalios sarpaginų šeimos alkaloidų sintezės paieška /
… in four steps enantioselectively and without protecting groups. Fischer indolization reaction to forge the natural product’s carbon framework was also investigated, which provided an access to Sarpagine related alkaloids and their synthetic analogues.
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Synthetic studies on the spiroacetal moiety of stenocarpin, a metabolite of Diplodia maydis
… moiety as well as the initial type of protecting groups, were employed in the development of the synthetic route. In the first route the spirocyclisation reaction of a benzyl protected intermediate followed by the syn elimination of the cis-diol group resulted in the formation of only …
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A Synthesis and Characterization of D-Lyxo-Hexos-5-Ulose From D-Mannose.
… be easily separated from triphenylcarbinol. The protecting groups on 19 were hydrolytically removed in the presence of H+ form resin to give the target compound 20. 5-Keto-mannose was characterized directly by 13C and high field (400 MHz) 1H n.m.r. and indirectly by GC/MS as its fully …
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CHEMICAL SYNTHESIS AND BIOLOGICAL EVALUATION OF CHONDROITIN SULFATE DISACCHARIDES
… units. Recently, it was shown that the sulfate groups present in chondroitin sulfate GAGs (CS) encode important functional information for the regulation of physiological processes. However, procurement of pure, homogenous CS motifs for biological evaluation is a challenging task due to …
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Synthesis and Properties of Selectively Modifiable Cyclodextrin Analogues
… the selective functionalization of the hydroxyl groups on the macrocycle. A novel strategy for the synthesis of CD analogues is described which involves the use of [3+2] Huisgen cycloadditions between azide and alkyne functionalities to form the macrocycles from linear precursors. This strategy …
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Efforts towards the synthesis of fully N-differentiated heparin-like glycosaminoglycans; and, Investigations into the mechanism of inactivation of RTPR by gemcitabine triphosphate
… The reaction is compatible with a range of protecting groups, as well as free hydroxyl groups. This method has been applied to develop a synthesis of 3-O-benzyl-1,2-O-isopropylidene-P-D-glucopyranosiduronate in seven steps and 32% overall yield.
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Chemi-Optogenetics: Photoactivatable Probes To Control Protein Proximity And Cellular Processes
… the chemical versatility of photoremovable protecting groups with the biological specificity of self-labelling proteins (i.e. Halo-tag, SNAP-tag, eDHFR), to develop a series of tools that localize proteins of interest to its target with spatiotemporal precision. The local proximity of a …
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