Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"Proteasome activity"”.
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Proteasome inhibition in chronic myeloid leukaemia
… of TKI-resistant BCR-ABL mutations. BCR-ABL activity is associated with increased proteasome activity and PI are cytotoxic against CML cell lines. We demonstrate that bortezomib is antiproliferative and induces apoptosis in CD34+ cells taken at diagnosis from patients with CP CML cells, with …
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A Role for PI31-Mediated Proteasome Regulation in Proteostasis and Neuronal Health
… of proteins is achieved by the Ubiquitin-Proteasome System (UPS), which governs a variety of cellular processes such as apoptosis, cell cycle progression, protein quality control, and metabolism. Using this system, cells maintain homeostasis by quickly and irreversibly altering signaling …
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PMI 5011 regulates the ubiquitin proteasome system in skeletal muscle
… that is primarily regulated by the ubiquitin-proteasome system. Studies have shown that an extensively characterized ethanol extract of Artemisia dracunculus L (Russian Tarragon), termed PMI 5011, enhances insulin signaling in human primary skeletal muscle cells and in a rodent model of …
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Acute hypoxia-induced diaphragm dysfunction is prevented by antioxidant pre-treatment
… was assessed using a sandwich immunoassay. Proteasome activity was measured using a spectrophotometric assay. Acute hypoxia decreased diaphragm force and fatigue. Ventilation during acute hypoxia was initially increased during the first 10 minutes, but quickly returned to normoxic levels for …
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Role of Multiple Toll-Like Receptor Activation in Regulating Cytotoxic T Cell Priming to Lympocytic Choriomeningitis Virus Infections
… molecule, was recently suggested to regulate proteasome activity; we sought to examine if NO can influence MHC-I antigen presentation during viral infections. The data in this section of the thesis provides evidence that combined TLR engagement can alter the presentation of certain CD8+ …
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Age related memory loss and the role of the ubiquitin proteasome system
… accumulation of damaged proteins. The ubiquitin-proteasome system (UPS), responsible for breaking down damaged proteins, exhibits dysfunction in neurodegenerative disorders like Alzheimer's disease or dementia. While we acknowledge that proteasome function declines with age, its specific …
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The study of sonic hedgehog signaling pathway in the development of lysosomal acid phosphatase (Acp2) mutant mice cerebellar granule cells
… which was accompanied by an increase in proteasome activity, suggesting that the significant reduction of granule cells in nax cerebellum is potentially due to the dysregulation of N-Myc via the abnormal ubiquitin-proteasome system activity.
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Muscle catabolism in cancer and its attenuation by eicosapentaenic acid
… an elevation in the gastrocnemius muscle in the activity and expression of regulatory components of the ubiquitin-proteasome proteolytic pathway. This was accompanied by an accelerated loss of muscle tissue correlating with an increase in overall weight loss, all of which were attenuated by prior …
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Proteasome Inhibition Enhances The Effect of Bikdd Gene Therapy
… pancreatic cancer. In this study, we proposed proteasome inhibition as a combinational therapy strategy with BikDD gene therapy to enhance the clinical benefits. Proteasome inhibition stabilized exogenously expressed BikDD protein, and significantly enhanced the apoptosis induction effect of …
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Synthesis of proteasome inhibitors: analogues of nelfinavir
… have an inhibitory effect on chymotrypsin-like activity of 20S proteasome. Previous studies also show the promotion of acceleration of the apoptosis process within cancer cells by inhibition of proteasome activity. Separate experiments proved nelfinavir 1 to be involved in the inhibition of Akt …
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Inhibition of pancreatic cancer progression through EMT inhibition and induction of ER stress
… in pancreatic cancer cells and reduced MMP-2 activity. In an orthotopic mouse model of pancreatic cancer, C150 significantly reduced tumor growth at the dose regimen of 15 mg/kg by intraperitoneal (IP) injection 3x weekly for 6 weeks. Mechanistically, C150 enhanced proteasome-mediated …
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Circadian Regulation of Protein Homeostasis
… this in the first results chapter, showing that proteasome activity is essential for temporal organisation of circadian transcriptional networks, and that cellular proteasome activity is circadian-regulated. In the subsequent chapter, using various protein labelling strategies, I describe …
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Inhibition of Deubiquitinase Activity and Ubiquitination of Jak2 Blocks Cytokine Signaling and Induces Tumor Cell Apoptosis
… WP1130 did not directly inhibit Jak2 kinase activity. Our results show that WP1130 induces rapid ubiquitination and subsequent re-localization of Jak2 into signaling incompetent aggresomes. In addition to Jak2, WP1130 also induces accumulation of other ubiquitinated proteins without …
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Epigenetic and Ubiquitin-Proteasome Mechanisms of Obesity Development
… exposure to a high fat diet dysregulates the activity of the ubiquitin-proteasome system, the master regulator of protein degradation in cells, in the hypothalamus of male rodents. Despite this, whether this can occur in both sexes and directly contributes to abnormal weight gain has not been …
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The Major Histocompatibility Complex (MHC) and the proteasome-ubiquitin pathway in T cell development
… molecules in T cell development as well as the proteasome role in antigen processing for MHC-mediated antigen presentation to T cells is well established. However, the contribution of nonclassical MHC molecules, the signals evoked by the MHC-TCR interactions, the signaling role of the …
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Substrate recognition by the 26S proteasome
The 26S proteasome is a large protein complex found in all eukaryotes. It controls the degradation of a wide range of proteins in the cell, and thus it is crucial for homeostasis, regulated cell division and apoptosis. It is known that specific signals (called degrons) on the substrates are …
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Global and chromosome-specific consequences of aneuploidy in Saccharomyces cerevisiae
… proteotoxicity in aneuploid yeast and impairs proteasome function. Indeed, our data suggest that Ubp3 has a role in maintaining full proteasome activity in euploid cells. Finally, this synthetic effect is conserved; depletion of the human homolog of UBP3, USPO, impairs aneuploid human cell …
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Sex-differences in proteasome-independent roles of the ubiquitin proteasome system in memory formation
… degradation during fear memory is the ubiquitin-proteasome system (UPS), which utilizes the small protein ubiquitin to label proteins. Ubiquitin contains eight linkage sites that each lead to a unique outcome for the protein being labeled and a protein can gain one (monoubiquitination) or …
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West Nile virus versus the host cell: Identification of host factors that modulate infection
… cells. Additionally, chemical inhibition of PKR activity or post-translational gene silencing of PKR expression severely impaired WNV-induced IFN production, suggesting that PKR is critical for the induction of IFN following WNV infection. Further analysis suggested that PKR may be important for …
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The role of glutamate transporters and the scaffolding protein IQGAP1 in the regulation of AMPA receptor trafficking and turnover
… in the strength of glutamatergic synaptic activity shape the synaptic localization of AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-type glutamate receptors (AMPARs), and this process is thought to underlie higher brain functions such as learning and memory. During excitatory …
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