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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 373 for “"Proteasome"”.
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Evolution of the Proteasome
Evolution of the proteasome multigene family was examined across all domains of life using experimental and computational techniques. First, degenerate primers designed to universally amplify all alpha proteasomes were used in the polymerase chain reaction with genomic DNA to probe the diversity of …
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Sex-differences in proteasome-independent roles of the ubiquitin proteasome system in memory formation
… degradation during fear memory is the ubiquitin-proteasome system (UPS), which utilizes the small protein ubiquitin to label proteins. Ubiquitin contains eight linkage sites that each lead to a unique outcome for the protein being labeled and a protein can gain one (monoubiquitination) or …
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Proteasome-Mediated Degradation of PNPLA3
Pages 33-49 are misnumbered as pages 34-50, pages 50-75 are misnumbered as pages 52-77, and pages 76-133 are misnumbered as pages 75-132.
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Proteasome inhibition in chronic myeloid leukaemia
… BCR-ABL activity is associated with increased proteasome activity and PI are cytotoxic against CML cell lines. We demonstrate that bortezomib is antiproliferative and induces apoptosis in CD34+ cells taken at diagnosis from patients with CP CML cells, with an LD50 below concentrations achieved …
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PORPHYRIN DERIVATIVES AS VERSATILE PROTEASOME MODULATORS
The ubiquitin proteasome system (UPS) is the primary degradation system in eukaryotic cells, with high selectivity for a myriad of soluble proteins, and perturbations in the UPS are associated with numerous human disorders. For this reason the proteasome has become a pharmacological target for …
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The proteasome and its ancillary proteins
The proteasome is an essential multi-protein complex found within all eukaryotes. It degrades unwanted proteins and is involved in regulating many cellular functions, including cell homeostasis and apoptosis. Previous research in the field mainly focused on the mechanisms by which substrate …
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Substrate recognition by the 26S proteasome
The 26S proteasome is a large protein complex found in all eukaryotes. It controls the degradation of a wide range of proteins in the cell, and thus it is crucial for homeostasis, regulated cell division and apoptosis. It is known that specific signals (called degrons) on the substrates are …
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PROTEASOME-DEPENDENT ENTRY OF HERPES SIMPLEX VIRUS
… that engages the host cell machinery. The proteasome is a large, ATP-dependent, multisubunit protease that plays a critical role in the maintenance of cell homeostasis. A battery of assays were used to demonstrate that proteasome inhibitors blocked an early step in herpes simplex virus …
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Investigating the early events in proteasome assembly
Proteasome assembly is a rapid and highly sequential process that occurs through a series of intermediates. While the quest to understand the exact process of assembly is ongoing, there remains an incomplete understanding of what happens early on during the process, prior to the involvement of the …
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Synthesis of proteasome inhibitors: analogues of nelfinavir
… effect on chymotrypsin-like activity of 20S proteasome. Previous studies also show the promotion of acceleration of the apoptosis process within cancer cells by inhibition of proteasome activity. Separate experiments proved nelfinavir 1 to be involved in the inhibition of Akt pathway – an …
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Metabolism of Alpha-Synuclein by the 20S Proteasome
… forms cause dysfunction of the ubiquitin-proteasome pathway of protein degradation, thereby enhancing an alternative pathway that involves ubiquitin-independent degradation by the 20S core particle of the proteasome. The 20S proteasome is known to degrade proteins with regions of intrinsic …
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Investigation of the potential bacterial proteasome homologue Anbu
… significant homology to the sub-units of the 20S proteasome and is predicted to be a novel bacterial proteasome. The goal of this project was to determine if the recombinant Anbu protein from Pseudomonas aeruginosa is a proteasome. Anbu from P. aeruginosa was successfully cloned, expressed and …
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Epigenetic and Ubiquitin-Proteasome Mechanisms of Obesity Development
… diet dysregulates the activity of the ubiquitin-proteasome system, the master regulator of protein degradation in cells, in the hypothalamus of male rodents. Despite this, whether this can occur in both sexes and directly contributes to abnormal weight gain has not been investigated. Here, we …
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Proteasome Inhibition Enhances The Effect of Bikdd Gene Therapy
… pancreatic cancer. In this study, we proposed proteasome inhibition as a combinational therapy strategy with BikDD gene therapy to enhance the clinical benefits. Proteasome inhibition stabilized exogenously expressed BikDD protein, and significantly enhanced the apoptosis induction effect of …
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PROTEASOME REGULATES TRANSCRIPTION AND TRANSLATION IN LONG-TERM SYNAPTIC PLASTICITY
… of regulatory proteins by the ubiquitin-proteasome pathway (UPP). To study the molecular mechanisms of learning and memory, we use the late phase of long-term potentiation (L-LTP) in the murine hippocampus as a cellular model of long-term synaptic plasticity. Our previous work identified …
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PMI 5011 regulates the ubiquitin proteasome system in skeletal muscle
… that is primarily regulated by the ubiquitin-proteasome system. Studies have shown that an extensively characterized ethanol extract of Artemisia dracunculus L (Russian Tarragon), termed PMI 5011, enhances insulin signaling in human primary skeletal muscle cells and in a rodent model of …
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Substrate Selection by the 20S Proteasome and Implications in Disease Pathogenesis
… forms of alpha-synuclein produced by the 20S proteasome in vitro, through a ubiquitin-independent mechanism, are similar to those found in the cingulate cortex of patients with Lewy body diseases. The work presented here describes an investigation into the mechanism by which alpha-synuclein is …
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Induction of Caspase-Dependent Death By Proteasome Targeted Therapy In Glioblastoma
… of only 14 months with current treatment. The proteasome inhibitor bortezomib (BTZ) shows efficacy in cancers like myeloma, but its clinical utility in other cancer types has been more limited. Newer proteasome inhibitors such as marizomib (MRZ) have unique inhibitory and death inducing …
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