Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Proteasomal pathway"”.
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The Gsk-3Β-Fbxl21 Axis Regulates Tcap Via Ubiquitin-Mediated Proteasomal Pathway In The Cytoplasm
… results revealed a new circadian regulatory pathway that FBXL21 regulates TCAP via ubiquitin-mediated proteasomal pathway in the cytoplasm coordinatively with GSK-3β.</p>
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Role of Sub-Cellular Localization and Cellular Factors In Regulation of HIV-1 Tat Protein Stability
… short half life of (3.5 ± 0.07) h. 26S proteasomal inhibitor, MG132 rescued Tat from degradation indicating that degradation occurs via the proteasomal pathway. Proteasomal pathway is active both in the cytoplasm and nucleus. Nuclear and cytoplasmic protein extracts prepared following …
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DEGRADATION OF XIAP AS A NOVEL TREATMENT STRATEGY IN HIGH-RISK NEUROBLASTOMA
… rapid degradation of XIAP through a ubiquitin-proteasomal pathway, worked synergistically with standard-of-care cytotoxic agents and prolonged the overall survival of high-risk MYCN-amplified neuroblastoma patient-derived xenografts. Collectively, this presents the degradation of XIAP mediated …
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HIJACKING OF CELLULAR PATHWAYS BY NOVEL TICK-BORNE PHLEBOVIRUS
… which were recovered when the Ubiquitin-Proteasomal Pathway was inhibited using MG-132. Lastly, we observed that mutation of ubiquitination sites of RIG-I and TBK-1 prevented and reduced the interaction with SFTS virus NSs, respectively. Altogether, our study suggests a novel mechanism …
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Novel Cellular Targets of Aspirin in Chemoprevention studies on P53, G6PD and c-MYC
… identify novel cyclooxygenase (COX)-independent pathways by which aspirin exerts its anticancer effects in epithelial cancer cell lines. We investigated the effect of aspirin on p53, glucose 6-phosphate dehydrogenase (G6PD), and c-Myc, all of which are known to play a major role in cancer …