Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Protease-activated receptor 1"”.
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Zyxin signaling: Protease-activated receptor-1 and Rho guanine nucleotide exchange factor p114.
Zyxin signaling: Protease-activated receptor-1 and Rho guanine nucleotide exchange factor p114.
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Re-evaluation of the in vitro activity of the protease activated receptor-1 (PAR1) pepducin PZ-128
… activity and prevent thrombus formation. Protease-activated receptor 1 (PAR1) is a key target due to its role in thrombin-mediated platelet activation.;PZ-128 is a cell penetrable pepducin that targets PAR1 and has entered phase II clinical trials, however, adverse effects in trial …
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Characterisation of the conformational landscape of the β1-adrenergic receptor and development of a strategy towards NMR studies of the protease-activated receptor 1
… minimally thermostabilised avian β1-adrenergic receptor (tβ1AR) using solution state nuclear magnetic resonance (NMR) spectroscopy. The tβ1AR is a class A G-protein-coupled receptor (GPCR) and the human counterpart is an important drug target in diseases of the heart. In chapter 2, a wide range …
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Identification of a vascular smooth muscle cell transition associated with fibrous cap formation and induced by thrombin receptor activation
… of human atherosclerotic plaques. From this, protease-activated receptor-1 (PAR1) emerged as a candidate regulator of fcVSMC generation. PAR1 was expressed in VSMCs within the fibrous caps of human plaques and its activation by thrombin in cultured human VSMCs induced expression of …
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Investigating novel therapeutic targets for treatment of visceral pain.
… diseases by: • Studying the effect of calcium activated potassium (KCa) channel openers on the activation of colonic afferents by prototypic algogenic stimuli. • Examining the effect of inflammatory mediators (angiotensin II and matrix metalloproteinase 1) upregulated during colitis on colonic …
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Harnessing Deep Learning with Protein Language Models to Unveil Microbial Enzyme Function in Health and Disease
… hypothesised to synthesise ligands for GPR35, a receptor genetically linked to IBD. These discoveries, facilitated by deep learning tools, could offer new insights into IBD pathology and lead to novel therapeutic targets. In the third chapter I detail the development of CAZyLingua, the first tool …
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Cathepsin S as a mediator of acute lung inflammation
… outcomes.<br/><br/>Proteolytic enzymes, or proteases, are known to play important roles in the maintenance of pulmonary homeostasis. However, during disease, proteolytic activity can become dysregulated and cause damage to the lung, contributing to the pathology of conditions like cystic …