Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Protease-Activated Receptor-2"”.
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Characterisation of novel compounds as antagonists of protease-activated receptor-2 (PAR2)
Protease-activated receptor-2 (PAR2) is a G-protein coupled receptor that is activated through proteolytic cleavage of the N-terminus leading to the coupling to a number of defined second messenger systems though G-protein engagement. Early signalling events such as the mobilisation of …
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Characterizing novel protease activated receptor 2 compounds for potential use in examining depression-like behavior
… patients. Particularly, the G-protein coupled receptor (GPCR) protease activated receptor 2 (PAR2) has received interest towards its link with depression, as this has shown to play a pro-inflammatory role in disorders of the central nervous system (CNS). However, previously it has remained a …
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Development and Testing of Pharmacological Tools to Evaluate the Role of Protease-Activated Receptor-2 in Allergic Asthma
… Extensive studies supporting a central role for Protease-Activated Receptor-2 (PAR2) in allergic asthma pathophysiology have promoted drug development efforts towards this molecular target. I report here that PAR2 antagonist C391 blocks signaling and symptoms caused by the asthma causing allergen …
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Mechanistic Studies On the Role of Polyamines and Microvesicles in Tumor Growth and Hypoxia-mediated Angiogenesis
… of tumor hypoxia. We have elucidated the role of protease-activated receptors in the hypoxic responses of endothelial cells, and found a specific role of protease activated receptor-2. We show that hypoxic coagulation system activation in glioblastoma cell derived microvesicles elicits …
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Effects of an Endothelial Cell-specific PAR2 Knockout on Endothelium-dependent and -independent Relaxation of Mouse Arteries
Protease-activated receptor 2 (PAR2), a G-protein-coupled receptor expressed on endothelial cells (EC), is a target in chronic inflammatory diseases. Understanding the functions of EC PAR2 will inform the development of PAR2-based therapeutics to treat endothelial dysfunction, a characteristic of …
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Investigation of the functions of Matrix Metalloproteinase-8 (MMP-8) in Mammary Carcinoma Cells
… matrix metalloproteinases (MMPs) are a family of proteases thought to promote metastasis due to their matrix degradation capabilities. MMP-8 however has been discovered to be anti-tumourigenic in many cancers, and anti-metastatic in breast cancer. This occurs through unknown mechanisms, so this …
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Role of Monocytes and Neutrophils in Thrombosis
… as the major leukocyte subtypes to which activated platelets rapidly adhere regardless of the agonist used. Secondly, it was found that activated platelets adhering to monocytes caused the monocytes to rapidly expose on their surface tissue factor, a potent activator of the blood …
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Mast Cell Influence in the Progression of Post-burn Hypertrophic Scar Pathophysiology
… fibroblasts. Tryptase, an abundant mast cell protease, directly cleaves and activates the protease-activator receptor-2 (PAR2) and activation has proliferative and fibrotic consequences. We demonstrate that PAR2 is highly expressed in post-burn HTSs and, activation sustains fibroproliferative …