Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Prostatic neoplasms"”.
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Antioxidant Programs Are Essential for Enzalutamide-Resistant Prostate Cancer
Therapy resistance to second generation androgen receptor (AR) antagonists, such as enzalutamide, is common in patients with advanced prostate cancer (PCa). In order to identify which patients will develop therapy resistance and the underlying cause, it is critical to characterize detailed …
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Prostate-specific Antigen Nadir and Time to Prostate-specific Antigen Nadir Following Maximal Androgen Blockade Independently Predict the Prognosis in Patients with Metastatic Prostate Cancer
PURPOSE: To evaluate the influence of prostate-specific antigen (PSA) kinetics following maximal androgen blockade (MAB) on the disease progression and cancer-specific survival in patients with metastatic, hormone sensitive prostate cancer. MATERIALS AND METHODS: One hundred thirty-one patients …
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The Role of Exercise on Masculinity, Body Image, and Quality of Life in Men with Prostate Cancer. A Mixed Methods Study.
Early research supports exercise in its role to improve masculinity and body image changes that may result from treatment; however, studies to date have largely examined limited treatment groups (i.e., those receiving androgen deprivation therapy) and did not include men from across the exercise …
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Addressing Label Variability in Deep Learning-Based Segmentation for Radiation Therapy
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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The Potential Role of LEDGF/p75 in Prostate Cancer
<p>The serum autoantibody repertoire from cancer patients is currently being exploited for the identification of tumor associated antigens (TAA) and the design of TAA arrays. Such arrays would facilitate autoantibody profiling and potentially aid in the serological diagnosis and prognosis of …
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Telomerase Activity in Prostatic Fluid and Tissue as a Marker for Prostate Cancer
… needle biopsy specimens and freshly collected prostatic fluid. Clinical application of a newly developed PCR-ELISA telomerase assay method is also evaluated. Multiple sextant needle biopsy specimens from 56 subjects and prostatic secretion specimens from 72 subjects, with or without prostate …
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Contribution of LEDGF/p75 to Prostate Cancer Chemoresistance
<p>Prostate cancer (PCa) is the second leading cause of male cancer death in the United States, and is considered a health disparity because of its disproportionate incidence and mortality in African American (AA) males. A major challenge in PCa treatment is its recurrence into hormone refractory …
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RNA-Seq Reveals Transcriptomic Program Associated with Stemness in Taxane Resistant Prostate Cancer
<p>There is no cure for advanced prostate cancer (PCa), and taxane chemotherapy is the only treatment option once other therapies have failed. However, this is problematic since all patients eventually develop chemoresistance. Emerging treatments for advanced PCa have shown promise at the …
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The Role of Glucocorticoid Signaling in Prostate Cancer Health Disparities
<p>African-American men are more likely to develop aggressive prostate cancer (PCa) and die from the disease than other ethnic groups. Glucocorticoid signaling is a contributing biological factor to worse PCa prognosis, and is emerging as a key driver of PCa progression in the absence of androgens. …
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Male Subfertility and Prostate Cancer Risk: Epidemiological and Genetic Studies
Androgen action plays a pivotal role in male reproductive tract physiology and pathology. The androgen receptor (AR) gene harbors two codon repeat tracts: the CAG and GGN repeats, encoding corresponding amino acid sequences of variable length; the polyglutamine and polyglycine stretches, …
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Prostate Cancer Screening Intention among Black Men: A Multivariate Analysis
<p>Prostate cancer is one of the leading causes of death among Black men, and widespread lack of screening contributes to the mortality burden. The purpose of this present study was to evaluate the effect of relationship intimacy with individual intent to screen using the digital rectal examination …
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Targeting LEDGF/p75 to Sensitize Chemoresistant Prostate Cancer Cells to Taxanes
<p>Prostate cancer (PCa) is the second most diagnosed cancer in males. This disease disproportionately affects African American men, with a higher incidence and mortality compared to other ethnic/racial groups. An aging male population and the complexity of addressing the health disparities …
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Proteomic Profiling of Serum Derived Exosomes from Prostate Cancer Patients
… by about a decade was the introduction of Prostatic Specific Antigen (PSA) into clinical practice; first as biomarker for monitoring response to therapy and subsequently as a complementary screening tool. It is not surprising then that a cause-effect relationship has been suggested. Like a …
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Biochemical and Functional characterization of the LEDGF/p75-MeCP2 Interaction in Tumor Cells
The lens epithelial derived growth factor p75 (LEDGF/p75) is a novel pro-survival and stress-inducible transcription co-activator that protects mammalian cells from various environmental stresses such as oxidative stress, heat shock, and serum starvation. This emerging cancer-related protein is …
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Prostate Cancer Screening of Heterosexual Caribbean American and African American Men and their Partners
<p>The incidence and prevalence of prostate cancer are very alarming among men in general, among African American men more narrowly, and among Caribbean American men more specifically. While the disease has variable impact on men of different racial and ethnic backgrounds the impact of the disease …
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Self-reported Exercise and Risk of Osteoporosis in Prostate Cancer Patients Receiving Androgen Deprivation Therapy
<p>Prostate cancer is stimulated to grow in response to testosterone. Androgen deprivation therapy (ADT) leads to chemical castration and suppression of prostate cancer cell production. Testosterone levels less then 300ng/ml decreases bone mineral density and could result in osteoporosis. Studies …
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The Relationship Between the Level of Support Group Participation and Psychosocial Factors in Prostate Cancer Patients Treated with Proton Therapy
<p><strong>Background.</strong> The role of support groups for cancer patients is known to be beneficial in helping people adjust to the disease, and cope with the myriad of effects that cancer has on quality of life. Although many people express interest in attending such support groups, few …