Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"Prostate tumor"”.
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Characterization of Mouse Prostate Tumor-Infiltrating Leukocytes
<p>Prostate cancer is the most common form of non-cutaneous cancer among men in the United States and the second most common cause of cancer-related death among men with approximately 189,000 new cases diagnosed and 30,200 deaths of the disease in 2002. Prostate cancer can be a treatable disease …
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Characterization of a Novel Prostate Tumor-Associated Antigen
… prostatic hyperplasia (BPH) and carcinoma of the prostate (CaP). Western blot analysis of prostate extracts, showed that MAb TURP-27 and MAb HNK-1 bound glycoproteins of 180, 140, 120, 100, 90 and 69 kDa. Studies have shown that the HNK-1 carbohydrate epitope may be involved in cell adhesion and …
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Gene Therapy Using Tet-Repressor System to Modulate Prostate Tumor Microenvironment
<p>Prostate cancer is the most commonly diagnosed malignancy in men in the United States and is projected to be the third most frequent cause of male cancer-related deaths in 2007 after lung and skin cancers. The initial treatment for prostate cancer at early stages is prostatectomy or radiation, …
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TGF-beta Activated Kinase-1 (TAK1) Is a Critical Prostate Tumor Suppressor
… deletion of the MAP3K7 gene is frequent (32%) in prostate cancer patients and is significantly associated with high grade prostate tumor. We hypothesize that TAK1 is a critical prostate tumor suppressor. In vitro, we knocked down TAK1 in an established mouse prostatic progenitor/stem cell (PrP/SC) …
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LET dependence of radiation-induced bystander effects using human prostate tumor cells
… was to characterize the ability of irradiated tumor cells to induce bystander effects in co-cultured cells. Human DU-145 prostate carcinoma cells were grown on a 1.4 [mu]m-thick mylar membrane in specially constructed cell culture dishes for irradiation with alpha particles (average energy 3.14 …
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Direct and indirect effects of alpha-particle irradiations of human prostate tumor cells
… effect of alpha-particle irradiations of human prostate tumor cells, toward the goal of improving the effectiveness of alpha-particle involved radiation therapies such as radioimmunotherapy and BNCT. This project consists of an engineering part and a biological part. In the engineering part, an …
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Cycled Pulsing for Prostate Tumor to Mitigate Thermal Damage, While Conserving the Ablation Area
Prostate cancer is one of the most common cancer-related diseases among men. Traditional treatment options cannot always treat the disease successfully as limitations and complications exist since the traditional treatments lack specificity and have an invasive nature. Focal therapy is a prominent …
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Adipocyte-Induced Inflammation In Prostate Tumor Progression In Bone: Role Of Cxcr2 And Osteopontin
<p>Abstract</p> <p>Prostate cancer (PCa) is the second leading cause of cancer-related deaths among men. Evidence suggests that age and obesity, conditions associated with adipocyte accumulation in the bone marrow, are linked to increased risk of developing PCa and progressing to metastatic …
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Overcoming dendritic cell-mediated suppression of T cell responses in a prostate tumor environment
Prostate cancer is the most prevalent malignancy in American men, leading to significant mortality each year. This is in part due to a lack of effective treatments for advanced disease. The prostate is considered an ideal organ for cancer immunotherapy, because it is both nonessential and expresses …
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Augmenting Natural Killer cell antibody binding to enhance ovarian and prostate tumor cell killing via ADCC
… cancer and metastatic castration resistant prostate cancer (mCRPC) are a leading cause of cancer-related deaths worldwide. Natural killer (NK) cells are cytotoxic lymphocytes that rapidly kill tumor cells via antibody-dependent cell-mediated cytotoxicity (ADCC). ADCC is exclusively mediated …
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Synergistic inhibition of prostate tumor progression with a combination of curcumin and ursolic acid in the diet
Prostate cancer (PCa) is the second leading cause of cancer death among men in the United States. The long latency of PCa tumorigenesis provides ample opportunity for chemopreventive strategies to be applied. Generally, phytochemicals have diverse impacts on multiple pathways that can affect cancer …
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The Role of Mir-34A In Inhibition of Prostate Tumor Growth In The Bone and Induction of Autophagy
<p>Prostate cancer (PCa) is the second leading cause of cancer-related deaths in men in the United States, with most deaths occurring from bone metastasis. Several new therapies have been FDA approved for bone-metastatic PCa, but patient survival has only marginally improved due to therapy …
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Roles of Nanog, a transcription factor for self-renewal of embryonic stem cells, in prostate tumor initiation and chemoresistance
Prostate cancer is one of the most common cancers affecting one of every six men in United States. It is increasingly appreciated that tumor or cancer stem cells are the cells responsible for initiating tumor formation and therefore should be targeted for eradication in cancer treatment. But the …
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The Influence of Beta-Carotene and Lycopene on Human Prostate Tumor Cells in Vitro and Human Prostate Tumors in Mice
… the influence of tomatoes, BC and lycopene on prostate carcinogenesis under biologically relevant conditions. To this end, a novel approach for the delivery of carotenoids to cells in culture and a murine model were developed. There was no evidence from the athymic model that whole tomato or …
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BOTH EFFECTOR AND INHIBITORY IMMUNE MECHANISMS ARE AMPLIFIED IN CASTRATION-RESISTANT PROSTATE CANCER
… is modulated by androgen ablation therapy for prostate cancer. Androgen ablation leads to apoptosis of primary prostate tumor and transient potentiation of immune function. However, immune inhibitory mechanisms employed by the tumor eventually prevent prolonged anti-tumor immunity. The …
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Synthetic Peptide Ligand Mimetics and Tumor Cell Motility
Human tumor cell progression and metastasis is partially dependent on the ability of tumor cells to adhere to the proteins of the extracellular matrix and migrate to distant locations. Using a combinatorial screening approach, six novel D-amino acid containing peptides were identified and analyzed …
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Molecular cell cycle mechanisms of human prostate crcinoma insensitivity to TGF-β?
… have studied the TGF-β1 effect on normal human prostate and carcinoma cells. Our results showed that normal cells were sensitive to growth inhibition, whereas tumor cells were not or only minimally inhibited regardless of the concentration of TGF-β1 (20 to 80 pM) or time of exposure (1-5 days). …
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ROLES OF 15-LIPOXYGENASE-2 (ALOX15B) IN SUPPRESSION OF TUMOR FORMATION, METASTASIS, AND SENSITIVITY TO CHEMOTHERAPY
… is a member of the lipoxygenase family with anti-tumorigenic activity. Like other lipoxygenase families, the main substrate for 15-LOX-2 in the Arachidonic acid. The main product of this enzyme is 15(S)-HETE. 15(S)-HETE control the proliferation in prostate cells. The expression of 15-LOX-2 lost …
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RNA-Seq Reveals Transcriptomic Program Associated with Stemness in Taxane Resistant Prostate Cancer
<p>There is no cure for advanced prostate cancer (PCa), and taxane chemotherapy is the only treatment option once other therapies have failed. However, this is problematic since all patients eventually develop chemoresistance. Emerging treatments for advanced PCa have shown promise at the …
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Allele-Specic QTL fine-mapping with PLASMA
… Applied to RNA-Seq data from 524 kidney tumor samples, PLASMA achieves a greater power at 50 samples than conventional QTL-based ne-mapping at 500 samples: with over 17% of loci ne-mapped to within 5 causal variants compared to 2% by QTL-based ne-mapping, and a 6.9-fold overall reduction …
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