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Showing 1 to 20 of 48 for “"Prostaglandin E2 (PGE2)"”.

  1. The Effect of impaired Cyclooxygenase 2 activity on gene regulation in the developing mouse brain and the role of PGE2 in oxidative stress production in Differentiated Neuronal Cells

    Udhesister, Sasha Tesna Persaud2021

    Prostaglandin E2 (PGE2) is a signaling molecule derived from the lipid membrane through the enzyme cyclooxygenase2 (COX-2). These studies aim to investigate how changes in COX-PGE2 signalling can influence mouse gene expression and alter oxidative stress in neuronal cells. In study 1 we use …

    york Repository record

  2. Charakterisierung von Prostanoidrezeptoren an Podozyten der Maus

    Kowark, Pascal

    Prostaglandine sind an der Regulation wichtiger glomerulärer Funktionen beteiligt und spielen eine Rolle in der Pathogenese glomerulärer Erkrankungen. In der vorliegenden Arbeit sollte der Einfluss verschiedener Prostaglandine auf das Membranpotential, die Ionenleitfähigkeit, cAMP Akkumulation und …

    freiburg-diss Repository record

  3. Functional Education of Monocytes During Infection

    Askenase, Michael Horne2015

    … microbes via secretion of the lipid mediator prostaglandin E2 (PGE2). Priming of monocytes for regulatory function preceded systemic inflammation and was initiated prior to bone marrow egress. Natural killer (NK) cell-derived IFN-γ promoted a regulatory program in monocyte progenitors during …

    penn Repository record

  4. Non-steriodal anti-inflammatory drug-mediated regulation of COX-2 and EP3 receptor expression in the M-1 murine cortical collecting duct cell line.

    Ferguson, Shawn.University of Ottawa (Canada)2009

    … duct (CCD) is a major site of intrarenal prostaglandin E2 (PGE2) synthesis. By indirect immunofluorescence using isoform specific antibodies, we have localized COX-1 and -2 immunoreactivity to all cell types of the murine M-1 CCD cell line. By, immunohistochemistry, both COX-1 and COX-2 …

    ottawa-retro Repository record

  5. Effect of Prostaglandin E2 on Mechanical Stresses Applied by MC3T3-E1 Osteoblast-like Cells on a Soft Hydrogel Substrate

    Deb Roy, Abhijit2011

    … are sensitive to mechanical stimuli and release Prostaglandin E2 (PGE2) when exposed to a fluid shear stress. The exact mechanism by which these cells sense mechanical stress is not well established. A study of the stresses applied by the osteoblasts, under the influence of PGE2, on a hydrogel …

    uconn-diss Repository record

  6. Identification of the Pla2 Responsible For Prostanoid Synthesis in Response to Inflammatory Cytokines

    Fernando, Chaminda2014

    … be responsible for approximately 50-60% of the PGE2 production in response to inflammatory cytokines. Thus, we hypothesized that a closely-related PLA2 is responsible for 40-50% of the PGE2 produced in response to inflammatory cytokines. To this end, we utilized RNAi technology, extensively …

    vcu Repository record

  7. Role of Extracellular Signal­-Regulated Kinase and Peroxisome Proliferator-­Activated Receptor gamma on Transforming Growth Factor-­β1-­Induced Human Endometrial Stromal Cell Decidualization

    장, 혜진2011

    … following conditions: DMEM/F-12 (10% FBS, 1 nM E2 and 100 nM P4). 5 ng/ml of TGF-β1, 50 nM of rosiglitazone (PPAR gamma agonist), and 20 μM of PD98059 (ERK inhibitor) were added according to experimental purposes. Trypan-blue and a hemocytometer were utilized to count the viable cell number. …

    ajou Repository record

  8. Effekte der Stimmungsstabilisatoren Lithium, Valproat und Lamotrigin auf die Cyclooxygenase-2-Synthese in SK-N-SH Neuroblastomzellen

    Ottomeyer, Caroline

    … die Cyclooxygenase (COX)-2-Synthese als auch die Prostaglandin E2 (PGE2)-Ausschüttung reduzieren. Aufbauend auf dieser Beobachtung sollten in dieser Arbeit die Effekte der Stimmungsstabilisatoren Lithium, Lamotrigin und Valproat auf die Interleukin-1beta induzierte Cyclooxygenase-2-Synthese in …

    freiburg-diss Repository record

  9. Effect of a single intra-articular injection of bupivacaine on synovial fluid prostaglandin E2 concentrations in normal canine stifles

    Giangarra, Jenna ElizabethVirginia Tech2018

    … is unknown, but may involve inflammation. Prostaglandin E2 (PGE2) is an inflammatory mediator and a marker of joint inflammation. The aim of this study was to compare synovial fluid PGE2 concentrations after a single intra-articular injection of bupivacaine with a saline control in normal …

    vt Repository record

  10. Neural and Behavioural Consequences of Chronic Inflammation following Spinal Cord Injury

    Allison, DavidBrock University2016

    … production of pain inducing eicosanoids such as prostaglandin E2 (PGE2). Immune dysfunction in the form of chronic inflammation may therefore contribute to the severity of behavioural disorders such as depression and cognitive impairment, as well as neural disorders such neuropathic pain and …

    brock Repository record

  11. The Effects of Dha Supplementation on Markers of Inflammation and Muscle Damage Following an Acute Eccentric Exercise Bout

    DiLorenzo, Frank MichaelVirginia Tech2012

    … voice commands. Fasted blood samples for prostaglandin E2 (PGE2), interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL1-ra), C-reactive protein and creatine kinase (CK) were assessed on days 1, 2 and 4. Fasted serum DHA was measured at baseline (day -28) and on day 1. Peak isometric …

    vt Repository record

  12. Estudo comparativo do efeito de warifteína e metil-warifteína, alcaloides de Cissamplelos sympodialis ECHL (Menispermaceae), no processo inflamatório agudo.

    Alves, Adriano FranciscoUniversidade Federal da Paraíba2014

    … the phlogistic agents in left paws, carrageenan, prostaglandin E2 ( PGE2) or bradyki nin and right paws in PBS. Edema was measured at 1, 2, 3 , 4, 6 and 24 hours for c arrageenan , 15, 30 and 60 minutes for PGE2 and 15 for 30min and bradykinin were measured with calipers . The vascular …

    brazil-ufpb Repository record

  13. Anti-Inflammatory Effect of Berry Essences

    Gu, Inah2019

    … and cytokines including nitric oxide (NO), prostaglandin E2 (PGE2), interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), which accelerate the development of other chronic diseases. Accordingly, targeting these pro-inflammatory factors is one of the important …

    arkansas Repository record

  14. Effect of Prostaglandin E2 on the Expression of Adhesion Molecules in Mouse Cerebrovascular Endothelial Cells

    박, 태엽2013

    Prostaglandin E2 (PGE2) is known to be the principal pro-inflammatory prostanoid and play an important role in brain disease through binding to four G protein-coupled receptor (EP1-4). However, there have been contradictory reports on its actions in inflammation processes. For instance, PGE2 …

    ajou Repository record

  15. Modulation of the sensitivity of nociceptive neurones by cannabinoids and SNSR

    Honan, Stuart AndrewUniversity of Cambridge2004

    … model and a model of sensitisation employing prostaglandin E2 (PGE2), it was evident that, in the in vitro model employed, the method of activating cannabinoid receptors did not result in any significant effect. Another family of G-protein coupled receptors found exclusively in sensory …

    cambridge Repository record

  16. The Role of Lipoprotein(a)/Apolipoprotein(a) in Endothelial Dysfunction: Mechanistic Studies in Vascular Endothelium

    Cho, Taewoo2009

    … of cyclooxygenase-2 (COX-2) and the secretion of prostaglandin E2 (PGE2) from the EC. Finally, we have presented data to suggest a novel inflammatory role for apo(a) in which it induces the activation of nuclear factor-kappaB through promotion of the dissociation of IkappaB from the inactive …

    queens Repository record

  17. Maternal Exposure to Prostaglandin E2 Affects Hippocampal Synaptic Plasticity in Mice Offspring -A Link to Autism Spectrum Disorder

    Abdul Rahiman, Aisha2023

    Prostaglandin E2 (PGE2) is a lipid signaling molecule involved in early healthy brain development. Exposure to environmental risk factors such as air pollutants, infections, and drugs such as acetaminophen during early pregnancy have shown to impact PGE2 levels and have all been linked to Autism …

    york Repository record

  18. Role of Toll-Like Receptor 4 in Oxidant-induced Inflammatory Phenotypes in Macrophages

    Zhang, YanUniversity of Missouri--Kansas City2017

    … with oxidants alone had a limited effect on prostaglandin E2 (PGE2) synthesis. In contrast, pM sensitized by prior treatment with LPS-EK followed by oxidant stimulation exhibited increased expression of COX-2 and an enhanced PGE2 production only in pM derived from TLR4-WT mice. Thus, we …

    umkc Repository record

  19. Investigating Prostaglandin E2 activation of the p38 pathway of oesophageal squamous cell carcinoma

    Rambout, XavierULiège. GxABT - Liège Université. Gembloux Agro-Bio Tech2008

    … In that context, it was postulated that prostaglandin E2 (PGE2), a hormone derived from a main component of maize, continuously triggers activation of proliferation and inflammation pathways. This work aimed at assessing the role of p38, a mitogen-activated protein kinase (MAPK), in the …

    liege Repository record

  20. Prostaglandin-Mediated Reinstatement of Drug Taking After Alcohol Drinking by Female Adolescent Rats

    Kline, Hannah L.2022

    … rats. Both alcohol and Meth increase the prostaglandin synthesis enzyme cyclooxygenase-2 (COX-2) in the brain but the effect of serial exposure to alcohol and Meth on COX-2 has not been determined. The first study uses a novel method of serial voluntary alcohol drinking and Meth …

    iupui Repository record

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