Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Prostaglandin E₂"”.
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The Cellular and Molecular Mechanisms of Prostaglandin E₂ in Myogenesis
Prostaglandin E₂ (PGE₂), the most abundant prostaglandin (PG) in our body, has multiple biological functions related to physiological activities and the development of diseases. Emerging evidence has shown that PGE2 plays an important role in regulating the survival and proliferation of …
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Regulation of Sodium Transport in A6 Epithelia by Prostaglandin E(2)
A pulse method of blocker-induced noise analysis was used to study the time-dependent changes of channel density (NT), channel open probability (Po) and single-channel current (iNa) of apical membrane epithelial Na + channels (ENaCs) in A6 epithelia in response to 1 muM PGE 2 added to the …
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A role for renal prostaglandin E in hemorrhagic shock in the dog
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Effects of a prostaglandin E₁ analogue, misoprostol, on gentamicin-induced nephrotoxicosis in dogs
… of the arachidonic acid cascade. Vasodilatory prostaglandins have been evaluated in experimental models of acute renal failure and clinical human medicine, with variable results. This study assessed potential protective effects of an oral prostaglandin E₁ analogue, misoprostol, in …
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Geburtseinleitung mit 2 mg Prostaglandin-E 2-Vaginalgel bei unreifem Zervixbefund (Bishop-Score 5)
… Zukünftige Studien zur Geburtseinleitung mit Prostaglandin-E2-Vaginalgel bei unreifem Zervixbefund sollten mit einer Quantifizierung des phosphorylierten IGFBP 1 im Zervikalsekret durchgeführt werden um einen optimale Schwellenwert für die Entwicklung eines Schnelltests für die klinische …
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A Possible Role For Prostaglandin E-B2-S as a Suppressor of Macrophage Phagocytosis
… The possibility that the factor could be a prostaglandin was investigated. When murine peritoneal macrophages were treated with prostaglandin E₂ (PGE₂) they phagocytized L. monocytogenes at a rate comparable to that phagocytized when treated with a low molecular weight fraction of …
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Binding and Signaling Differences between Prostaglandin E1 and E2 Mediated by Prostaglandin E Subtype Receptors
Prostaglandin E1 (PGE1) and E2 (PGE2) are ligands for the prostaglandin E2 receptor (EP) family, which consists of four subtype receptors, designated as EP1, EP2, EP3 and EP4. Interestingly, PGE2 mediates inflammation whereas PGE1 acts as an anti-inflammatory factor. However, the molecular basis of …
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The Effects of Biological Response Modification and Diet on the Immune Respose of Tumor-bearing mice
… 2-amino-5-bromo-6-methyl-4-pyrimidinone (ABMP), Prostaglandin E<sub>1</sub> (PGE<sub>1</sub>), singly and in combination, for 2 hours prior to mixing with target cells. Treated spleen cells from Diet 1 tumor-bearing animals at 3-6 weeks post-injection had substantially increased CIL response …
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Arachidonic acid metabolism by early ovine embryos and the role of prostaglandins in one aspect of embryonic development
… primarily an unidentified polar compound, 6-keto-prostaglandin F₁⍺ (6-keto-PGF₁⍺), prostaglandin F₂⍺ (PGF₂⍺), prostaglandin E₂ (PGE₂), 13,14-dihydro-15-keto prostaglandin F₂⍺ (PGFM), prostaglandin B₂ (PGB₂) and 12L-hydroxy-5,8,10-heptadecatrienoic acid (HHT). Experiment 2 was to determine whether …
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Anti-oxidant Action and Anti-aging Activity of Phenylpropanoid Compounds
… histamine assay, arachidonic acid release and prostaglandin E₂ assay in RBL 2H3 mast cells were measured and NIH 3T3 cell was used for collagen synthesis assay. Balb-c mouse were used to measure collagen assay, MPO assay, PLA₂ activity and lipid peroxidation in vivo system. Result: In DPPH …
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Expression and functional role of cyclooxygenase enzymes in cervical carcinoma
… and cyclooxygenase-2 expession and prostglandin E₂ synthesis are up-regulated in cervical cancers. Real-time quantitative reverse-transcriptase polymerase chain reaction and Western blot analysis confirmed cyclooxygenase-1 and cyclooxygenase-2 ribonucleic acid and protein expression in all cases …
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Regulation of macrophage activities by tumor growth: mechanisms of immunosuppression
… Mφ production of the suppressor molecules prostaglandin E₂ (PGE₂), nitric oxide (NO), and tumor necrosis factor-α (TNF-α). A major finding was that TNF-α's normal up-regulatory action on T-cell proliferation switched to a suppressor action when Mφ were present. The autocrine action of …
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Cyclooxygenase-2 and prostaglandins in human endometrial function
A role for cyclooxygenase enzymes and prostaglandins (such as prostaglandin E2) has been observed in benign endometrial pathologies (endometriosis, excessive blood loss and dysmenorrhoea) and in adenocarcinoma. Cyclooxygenase and prostaglandin E synthase enzymes catalyse the conversion of …
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Progesterone Action on Hypothalamic Lhrh Neurons: In Vitro and In Vivo Studies
… the estrous cycle, and (4) It was evident that a prostaglandin E(,2) activity and a cyclic AMP-generating system was involved in the P-stimulated LHRH release.
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Progesterone control of human endometrial cells
… the protein kinase A/cAMP pathway, such as Prostaglandin E₂ (PGE₂) and relaxin, are potent inducers of decidualisation when administered alongside progesterone in endometrial stromal cells (ESCs) in vitro. Uterine Natural Killer (uNK) cells increase in number in secretory phase endometrial …
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ROLE OF OXYTOCIN AND OXYTOCINASE IN THE MATERNAL RECOGNITION OF PREGNANCY
… expression of both endometrial and luteal prostaglandin E synthase (PTGES). Furthermore, PTGES expression was higher in diestrous, pregnant and oxytocin treated mares, suggesting that prostaglandin E (PGE) may have a luteoprotective role. To further characterize the gene expression during …
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Synthetic studies on prostaglandins: "synthesis of a new thia-PGEI analog"
… (±)-1 carrying the upper side-chain of prostaglandin E 1 was prepared by a step-wise synthesis involving transformations of compounds possessing the required carbocyclic framework (see scheme 27). The synthesis proved to be convenient and gave a good overall yield of (±)-1 which was …
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