Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 271 for “"Prostaglandin"”.
-
Binding and Signaling Differences between Prostaglandin E1 and E2 Mediated by Prostaglandin E Subtype Receptors
Prostaglandin E1 (PGE1) and E2 (PGE2) are ligands for the prostaglandin E2 receptor (EP) family, which consists of four subtype receptors, designated as EP1, EP2, EP3 and EP4. Interestingly, PGE2 mediates inflammation whereas PGE1 acts as an anti-inflammatory factor. However, the molecular basis of …
-
Einschränkung hepatischer Abwehrreaktionen während einer Entzündung durch Prostaglandin E2 über Gs-Protein-gekoppelte Prostaglandin E2-Rezeptoren
Die Akutphase-Antwort ist eine komplexe Reaktion auf Verletzungen und Infektionen. Sie wird initiiert und aufrechterhalten durch Cytokine, wie z. B. TNFalpha (Tumor Nekrose Faktor alpha) und IL-6 (Interleukin-6). Diese Cytokine werden u. a. in großen Mengen lokal in der Leber durch die dort …
-
Hydroperoxide stimulation of prostaglandin endoperoxide synthase
ETDs are only available to UIUC Users without author permission
-
Prostaglandin metabolism in the ovine corpus luteum
… relative importance of luteal biosynthesis of prostaglandin and possible catabolism of PGF2α by the corpus luteum. Expression patterns of two enzymes (cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase) important to prostaglandin synthesis and catabolism are described herein. On day 4 …
-
Strategies towards the synthesis of prostaglandin analogues
… strategies for the synthesis of cyclopentenone prostaglandins and their analogues have been explored. The key transformation critical to the success of each of the described routes involves a Lewis-acid mediated retro Diels-Alder (rDA) reaction as the final step in liberating a 4, 5 …
-
Modulation der Insulinsignalgebung durch Prostaglandin E2 und Endocannabinoide
Die adipositasbedingte Insulinresistenz geht mit einer unterschwelligen Entzündungsreaktion einher. Als Antwort auf dieses Entzündungsgeschehen wird PGE2 unter anderem von Kupffer Zellen der Leber freigesetzt und kann seine Wirkung über vier PGE2-Rezeptorsubtypen (EP1-EP4) vermitteln. In …
-
Localization of Human Prostaglandin E2 Receptors in Polarized Epithelial Cells
… in subcellular localization of the human prostaglandin E2 receptors. The EP receptors are all GPCRs, which differ in their second messenger pathways. The EP3 receptor is unique in that it has eight different isoforms that differ in the lengths of the carboxyl tail. The EP3 isoforms, as …
-
The Cellular and Molecular Mechanisms of Prostaglandin E₂ in Myogenesis
Prostaglandin E₂ (PGE₂), the most abundant prostaglandin (PG) in our body, has multiple biological functions related to physiological activities and the development of diseases. Emerging evidence has shown that PGE2 plays an important role in regulating the survival and proliferation of …
-
Inhibition and inactivation of prostaglandin synthase-2 and horseradish peroxidase
Prostaglandin synthase (PGHS) is a bifunctional enzyme of particular pharmaceutical interest, containing both cyclooxygenase (COX) and peroxidase (POX) active sites. Development of PGHS-2-selective POX inhibitors may reduce the toxic and carcinogenic effects of PGHS-2 xenobiotic activation, as well …
-
Relationships among progesterone, estradiol-17β, 13, 14-dihydro-15-keto-prostaglandin F₂α and prostaglandin F₂α in intact ewes around the time of luteolysis
… mechanisms controlling uterine secretion of prostaglandin F₂α (PGF₂α) are not known. This study (Experiments 1, 2 and 3) was conducted to evaluate the relationships of progesterone and estrogen to changes in 13,14-dihydro-15-keto-prostaglandin F₂α (PGFM) and PGF₂α in ewes. Experiment 1 was …
-
Targeting Prostaglandin E2 Receptor EP2 for Treatment of High-Risk Neuroblastoma
<p>Prostaglandin E2 (PGE2) is a predominant proinflammatory regulator that plays pivotal roles in regulating tumor cell proliferation, migration, and invasion. It fosters an inflammation-enriched microenvironment that facilitates angiogenesis and immune evasion. Neuroblastoma (NB) is a lethal …
-
Regulation of Sodium Transport in A6 Epithelia by Prostaglandin E(2)
A pulse method of blocker-induced noise analysis was used to study the time-dependent changes of channel density (NT), channel open probability (Po) and single-channel current (iNa) of apical membrane epithelial Na + channels (ENaCs) in A6 epithelia in response to 1 muM PGE 2 added to the …
-
Essential Fatty Acid Deficiency: Effects on Prostaglandin Synthesis and Immune Response
… fatty acid (EFA) deficiency is known to alter prostaglandin (PG) synthesis and immune response in several species. These experiments were designed to investigate PG production and the immune response of EFA-deficient Lewis rats and A/J mice.
-
The Prostaglandin E2 Receptor Subtype 3E and its involvement in tauopathies
… pathway which play a key role in synthesising prostaglandin E2 (PGE2) from arachidonic acid. PGE2 has been implicated in preclinical stages of Alzheimer’s disease, where elevated levels of PGE2 in the cerebrospinal fluid can be found, as well as aberrant amyloid processing in experimental …
-
The role of nitric oxide and prostaglandin E2 in prolonged hemorrhagic shock
… of NO might be further worsen when coupled with prostaglandin E2, a known vasodilator, in prolong hemorrhagic shock. Nitric oxides being a vasodilator might be responsible for the loss of vascular hyporesponsiveness in the presence of a potent vasoconstrictor, angiotensin II, in our model of …
-
A role for renal prostaglandin E in hemorrhagic shock in the dog
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
Page 1 of 14