Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"Prostacyclin"”.
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The utilization of the prostacyclin analogue iloprost in the cryopreservation of stallion spermatozoa
… The current study evaluated the potential of the prostacyclin analogue as a protective additive to stallion semen during cryopreservation. Collections were taken from 12 stallions and divided into four samples, one to be designated as control and the other three to be exposed to various levels of …
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Mechanisims of prostacyclin-induced modulation of neuropeptide release from rat sensory neurons grown in culture
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Effect of Fatty Acid Modification on Prostacyclin Production in Cultured Human Endothelial Cells (Arachidonate, Elcosapentaenoate)
… acid (AA) and eicosapentaenoic acid (EPA) on prostacyclin synthesis. Supplemental levels of fatty acids (20-150 (mu)M) were supplied as sodium salts bound to bovine serum albumin (3:1 mole ratio) and added to M-199 with 20% fetal bovine serum. Both AA and EPA were readily incorporated into …
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The Role of Silicates in Interstitial Lung Disease
… or silica particles respectively. An increase in prostacyclin release after exposing endothelial cells to asbestos has been reported. This study attempts to elucidate the role of lung epithelial cells in the generation of asbestos induced ILD. A cell model to study crocidolite-induced toxicity was …
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The Role of Silicates in Interstitial Lung Disease
… or silica particles respectively. An increase in prostacyclin release after exposing endothelial cells to asbestos has been reported. This study attempts to elucidate the role of lung epithelial cells in the generation of asbestos induced ILD. A cell model to study crocidolite-induced toxicity was …
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Einfluß der endothelialen Autakoide NO und PGI2 auf die Permeabilität endothelialer Gap Junctions
… wirksame Gewebshormone (Autakoide, wie NO und Prostacyclin) die Durchlässigkeit der Gap Junctions beeinflussen. Hierzu wurde in konfluenten Kulturen von humanen umbilikalvenösen Endothelzellen (n=190) die Ausbreitung der Farbstoffe Carboxyfluoresein und Calcein nach Injektion in eine einzelne …
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ASPECTS OF FLUID THERAPY: An experimental study of the effects of systemic inflammation, microvascular permeability, blood pressure and plasma volume
… compared the ability of activated protein C and prostacyclin to counteract an increased protein leakage in septic inflammation. Plasma volume expanding capacity of currently used colloid solutions was evaluated in standardized models of hypovolaemia. Plasma volume was measured with a 125I-albumin …
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Psychological, cardiovascular and haematological aspects of the type A behaviour pattern in relation to coronary heart disease
… thromboxane A2 , and the anticoagulatory prostacyclin). Different response patterns emerged prior to, and following a mental arithmetic challenge. The task anticipation effect involved elevated heart rate, systolic and diastolic pressure, plasma adrenaline and prostacyclin. Type A's …
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Liposomal delivery of PDE5 inhibitors and UT-15C to human erythrocytes
… PVR with the administration of drugs such as prostacyclin or its analogs and phosphodiesterase 5 (PDE5) inhibitors. These medications can be used alone or in combination and may have serious unwanted side effects that are additive when used in combination.</p><p>Here an alternative drug …
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The Influence of Dietary Fat on The Cerebral Microvasculature: Compositional, Prostaglandin Synthetic, and Permeability Studies
… of phospholipids, prostaglandin F(,2(alpha)) and prostacyclin synthesis by cortical slices and microvessels, respectively, kinetic parameters of adenosine uptake, and the potential involvement of eicosanoids in the uptake process.
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On Brain Oedema
… study III, it was shown that post treatment with prostacyclin in experimental meningitis reduces systemic plasma volume loss, and may diminish the rise in intracranial pressure. In study IV, the effect of statin treatment after brain trauma in rats was investigated. No effect on brain oedema, …
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Antiplatelet and antihypertensive actions of ridogrel
… thromboxane B2 synthesis without affecting renal prostacyclin synthesis. Blood pressure was reduced despite an increase in plasma renin activity. The pressor response to the TP receptor agonist U46,619 was shifted to the right following ridogrel pre-treatment, confirming competitive TP receptor …
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1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine (Platelet Activating Factor): Interactions with Sheep Platelets
… <p>Modulators of platelet activation such as prostacyclin, TMB-8 and indomethacin, had similar effects on the magnitude of response by aggregation and SCP assay. Both ATP release and SCP were inhibited in proportion to the concentration of prostacyclin. Neither aggregation nor SCP was affected …
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Effects of iloprost on embryo development in vitro
… been reported that Iloprost, a biosynthetic prostacyclin analogue and cardiovascular active drug, enhances embryo development and prevents apoptosis. It is hypothesized that the mechanism involves the induction of the survivin pathway. In this study, growth patterns of mouse embryos in four …
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Regulation of specific connexins differentially alters gap junction permeability and endothelial cell function
… transforming growth factor-[Beta][ (TGF-[beta]), prostacyclin, and endothelial nitric oxide synthase (eNOS). siRNA inhibition of connexin 43 in porcine aortic endothelial cells (PAEC) significantly decreased the diffusion distance of Lucifer yellow dye and cytoplasmic calcium levels after …
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New routes to enantioenriched substances through small organic molecules
… stable and biologically active mimic of prostacyclin PGI2 is synthesized following a ‘green approach’. An example of simple optical resolution of this racemic intermediate involving the diastereoisomeric salt formation is described.
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The Microcirculation in Trauma and Sepsis
… trauma itself and thereafter treatment with prostacyclin (PGI2) on PV-loss, transcapillary escape rate (TER) of 125I-albumin and cytokine release. In experimental sepsis, we studied the importance of charge for microvascular permeability and observed the effectiveness of albumin versus …
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Regulation of blood platelet function by nitric oxide
… Endothelial-derived nitric oxide (NO) and prostacyclin (PGI₂) are strong negative regulators that modulate platelet adhesion, activation, aggregation, secretion and shape change. In this study the effects of NO on Ca²+ dependent and independent pathways of activation were investigated. The …
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The role of reactive oxygen species in the endothelium derived hyperpolarising factor response
… endothelium-dependent but nitric oxide (NO) and prostacyclin (PGI2) -independent vasodilatation pathway that is the dominant relaxation mechanism in the microcirculation, and has been shown to require IKCa and SKCa channel activation and also functional myoendothelial gap junctions. Reactive …
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Regulation of blood platelet function by the AGC family of protein kinases
… platelet reactivity (1) nitric oxide (NO); (2) prostacyclin (PGI₂ ); and (3) the ectonucleotidase CD39. NO and PGI2 stimulate signalling cascades that result in the activation of the AGC family of Ser/Thr protein kinases (PKA, PKG and PKC). Once activated these kinase blunt platelet function …
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