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Showing 1 to 20 of 86 for “"Propofol"”.
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Pharmacokinetics of propofol in cats
… of the lipid emulsion formulation in 1986, propofol has become established for induction as well as for maintenance of anaesthesia in veterinary practice1 including cats2;3-8. Propofol is rapidly metabolized by hepatic glucuronidation in most species and it has also been shown to undergo …
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Quantifizierung von Propofol in der Atemluft mittels endtidaler Ionenmobilitätsspektrometrie
Das Injektionshypnotikum Propofol wird häufig im Rahmen der total intravenösen Anästhesie eingesetzt. Bei der Verwendung der Substanz können Komplikationen sowohl bei einer zu geringen als auch zu hohen Dosierung auftreten. Bei Fehlen einer Spiegel-Kontrolle erfolgt die Applikation bis heute …
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Propofol: Neuroprotektion in einem In-vitro-Modell des traumatischen Hirnschadens
INTRODUCTION: The anaesthetic agent propofol (2,6-diisopropylphenol) has been shown to be an effective neuroprotective agent in different in vitro models of brain injury induced by oxygen and glucose deprivation. We examined its neuroprotective properties in an in vitro model of traumatic brain …
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Statistical Modeling of Disrupted Sensory Processing during Propofol Mediated Unconsciousness
… which patients are unaware of their environment. Propofol, the most widely used anesthetic agent, induces slow-oscillations in local-field potential (LFP) recordings. Spiking becomes strongly coupled to the phase of the slow-oscillations, creating alternating irregular “Up” and “Down” states of …
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Pain induced by propofol - clinical studies on drug composition and adminstration
… faster recovery after anaesthesia and sedation. Propofol (2,6-di-isopropylphenol), one of our most common iv anaesthetics, is associated with pleasant sleep and rapid recovery with little postoperative nausea. When used for anaesthetic induction propofol causes severe or even intolerable pain or …
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Alpha thalamocortical networks during propofol general anesthesia and disorders of consciousness
… DoC. To map thalamocortical networks involved in propofol-induced unconsciousness, we conducted coherence analysis of alpha networks in intracranial EEG recorded in patients with pharmacologically-refractory epilepsy and performed probabilistic tractography analysis of thalamocortical fibers in a …
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Intracranial electroencephalography signatures of the induction of general anesthesia with Propofol
General anesthesia is a drug-induced, reversible behavioral state characterized by hypnosis (loss of consciousness), amnesia (loss of memory), analgesia (loss of pain perception), akinesia (loss of movement), and hemodynamic stability (stability and control of the cardiovascular, respiratory, and …
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Sedierung mit Propofol und Remifentanil zu diagnostischen und interventionellen Herzkatheteruntersuchungen im Kindesalter
… mittels kontinuierlicher Infusion von Propofol und Remifentanil sowie intermittierenden Bolusgaben an Propofol nach intravenöser Prämedikation mit Midazolam, zur diagnostischen oder therapeutischen Herzkatheteruntersuchung im Kindesalter untersucht. Es handelt sich dabei um eine …
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Shedding Light On General Anesthesia: Uncovering The Molecular Mechanisms For Propofol And Volatile Anesthetics
… the most commonly used intravenous anesthetic, propofol. A novel photoaffinity ligand for sevoflurane was validated and applied to uncover the unique mechanism of sevoflurane positive modulation of mammalian Shaker Kv1.2 channels. This novel sevoflurane photoaffinity ligand was in addition to a …
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Correction of target-controlled infusion following the wrong selection of emulsion concentration of propofol
… wrong-settings of emulsion concentrations of propofol as a countermeasure against erroneous target-controlled infusions (TCI). Methods: TCIs were started with targeting 4.0 μg/ml of effect-site concentration (Ceff) of propofol, and the emulsion concentrations were selected for 2.0% instead of …
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The Effects of Prophylactic Metoclopramide and Induction with Propofol on Postoperative Nausea and Vomiting
… prophylactic metoclopramide and induction with propofol on PONV. One hundred and sixty five patients undergoing laparoscopic cholecystectomy were randomized to four groups. Group 1 is control group, Group 2 (MCP group) is administrated with prophylactic metoclopramide 10 mg, Group 3 (propofol …
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Total intravenous anaesthesia in dogs: development of a target controlled infusion (TCI) scheme for propofol
The aim of this work was to develop a propofol (PPF) based Total Intravenous Anaesthesia (TIVA) technique to be used in dogs by veterinary surgeons in practice. As PPF is a poor analgesic agent, this work also looked into the development of a co-infusion scheme for the potent alpha2-adrenoceptor …
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