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Showing 1 to 20 of 70 for “"Propofol"”.
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Pharmacokinetics of propofol in cats
… of the lipid emulsion formulation in 1986, propofol has become established for induction as well as for maintenance of anaesthesia in veterinary practice1 including cats2;3-8. Propofol is rapidly metabolized by hepatic glucuronidation in most species and it has also been shown to undergo …
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Quantifizierung von Propofol in der Atemluft mittels endtidaler Ionenmobilitätsspektrometrie
Das Injektionshypnotikum Propofol wird häufig im Rahmen der total intravenösen Anästhesie eingesetzt. Bei der Verwendung der Substanz können Komplikationen sowohl bei einer zu geringen als auch zu hohen Dosierung auftreten. Bei Fehlen einer Spiegel-Kontrolle erfolgt die Applikation bis heute …
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Statistical Modeling of Disrupted Sensory Processing during Propofol Mediated Unconsciousness
… which patients are unaware of their environment. Propofol, the most widely used anesthetic agent, induces slow-oscillations in local-field potential (LFP) recordings. Spiking becomes strongly coupled to the phase of the slow-oscillations, creating alternating irregular “Up” and “Down” states of …
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Pain induced by propofol - clinical studies on drug composition and adminstration
… faster recovery after anaesthesia and sedation. Propofol (2,6-di-isopropylphenol), one of our most common iv anaesthetics, is associated with pleasant sleep and rapid recovery with little postoperative nausea. When used for anaesthetic induction propofol causes severe or even intolerable pain or …
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Alpha thalamocortical networks during propofol general anesthesia and disorders of consciousness
… DoC. To map thalamocortical networks involved in propofol-induced unconsciousness, we conducted coherence analysis of alpha networks in intracranial EEG recorded in patients with pharmacologically-refractory epilepsy and performed probabilistic tractography analysis of thalamocortical fibers in a …
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Intracranial electroencephalography signatures of the induction of general anesthesia with Propofol
General anesthesia is a drug-induced, reversible behavioral state characterized by hypnosis (loss of consciousness), amnesia (loss of memory), analgesia (loss of pain perception), akinesia (loss of movement), and hemodynamic stability (stability and control of the cardiovascular, respiratory, and …
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Sedierung mit Propofol und Remifentanil zu diagnostischen und interventionellen Herzkatheteruntersuchungen im Kindesalter
… mittels kontinuierlicher Infusion von Propofol und Remifentanil sowie intermittierenden Bolusgaben an Propofol nach intravenöser Prämedikation mit Midazolam, zur diagnostischen oder therapeutischen Herzkatheteruntersuchung im Kindesalter untersucht. Es handelt sich dabei um eine …
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Shedding Light On General Anesthesia: Uncovering The Molecular Mechanisms For Propofol And Volatile Anesthetics
… the most commonly used intravenous anesthetic, propofol. A novel photoaffinity ligand for sevoflurane was validated and applied to uncover the unique mechanism of sevoflurane positive modulation of mammalian Shaker Kv1.2 channels. This novel sevoflurane photoaffinity ligand was in addition to a …
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Correction of target-controlled infusion following the wrong selection of emulsion concentration of propofol
… wrong-settings of emulsion concentrations of propofol as a countermeasure against erroneous target-controlled infusions (TCI). Methods: TCIs were started with targeting 4.0 μg/ml of effect-site concentration (Ceff) of propofol, and the emulsion concentrations were selected for 2.0% instead of …
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The Effects of Prophylactic Metoclopramide and Induction with Propofol on Postoperative Nausea and Vomiting
… prophylactic metoclopramide and induction with propofol on PONV. One hundred and sixty five patients undergoing laparoscopic cholecystectomy were randomized to four groups. Group 1 is control group, Group 2 (MCP group) is administrated with prophylactic metoclopramide 10 mg, Group 3 (propofol …
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Total intravenous anaesthesia in dogs: development of a target controlled infusion (TCI) scheme for propofol
The aim of this work was to develop a propofol (PPF) based Total Intravenous Anaesthesia (TIVA) technique to be used in dogs by veterinary surgeons in practice. As PPF is a poor analgesic agent, this work also looked into the development of a co-infusion scheme for the potent alpha2-adrenoceptor …
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Effect-site consentration of remifentanil for nasotracheal versus orotracheal intubation during propofol target-controlled infusion
… nasotracheal (NT) intubation in adults after propofol target-controlled infusion (TCI) without neuromuscular blocking agent, and whether or not these concentrations differ from those for orotracheal (OT) intubation. Methods: Fifty patients were assigned to receive either OT intubation (OT …
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Neuroprotective Effects of Propofol and Ketamine(alone or combined) Against Oxygen-Glucose Deprivation-Reperfusion Injury
"허혈-재관류 뇌손상에 대한 Propofol, Ketamine 단독 혹은 혼합 투여의 효과 연구 목적 : Propofol 과 ketamine 은 뇌보호 작용이 있는 것으로 알려져 있으나, 이들 두 약제를 동시에 사용하는 것이 뇌보호 작용에 어떤 효과가 있는지에 대하여는 잘 알려져 있지 않다. 본 실험연구는 propofol 과 ketamine 을 같이 사용하는 것이 허혈-재관류로 인한 뇌손상으로 부터 뇌세포를 보호하는데 부가적인 효과가 있는지 알아보기 위하여 시행하였다. 연구 방법 : 13일째 혼합 배양된 세포를 무산소, 무포도당 …
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Untersuchung der Patientenzufriedenheit und der Qualität einer Propofol/Midazolam-Sedierung bei endoskopischen Eingriffen in der Gastroenterologie
… sowohl die Patientenzufriedenheit mit einer Propofol/Midazolam-Sedierung bei verschiedenen gastroenterologischen Eingriffen als auch die Sicherheit dieser Sedierung an einem stationären Patientengut (n=269) ermittelt. Des Weiteren wurden die Veränderungen der Laborwerte AST, ALT, γ-GT und …
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The Effects of Prophylatic Dolasetron and Induction with Propofol on Postoperative Nausea and Vomiting After Thyroidectomy
"국문요약 1 차례 3 표차례 4 Ⅰ. 서론 5 Ⅱ. 연구대상 및 방법 7 Ⅲ. 결과 9 Ⅳ. 고찰 11 Ⅴ. 결론 15 참고문헌 21 ABSTRACT 27 "
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Transdermal Iontophoretic Delivery Of Lipophilic Drugs
… charge and poor water solubility of molecules. Propofol, a sedative and anesthetic drug was chosen as a one of the model lipophilic drug in this study. Initially, feasibility of delivery of propofol phosphate, a water soluble prodrug of propofol, via transdermal route using iontophoresis in …
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The Effects of Propofol, Sodium Pentobarbital, and Ketamine Hydrochloride on <i>In Vitro</i> Mouse Embryonic Development
… the normal clinical dosage range for mice (propofol 50-200mg/kg, sodium pentobarbital 50mg/kg, and ketamine hydrochloride 50-100mg/kg) for 72h to determine the effects of each anesthetic on subsequent cleavage and development during prolonged exposure. The anesthetic dosage ranges were as …
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The Effect of Atropine on the Bispectral Index Response to Endotracheal Intubation during Propofol and Remifentanil Anesthesia
Atropine has been reported to increase the propofol requirements for the induction of anesthesia during continuous infusion of propofol. Activation of the peripheral nerve system by endotracheal intubation is accompanied by an increase in bispectral index (BIS). The purpose of this study was to …
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Cross-Simulation of the Predicted Concentrations between the Two Pharmacokinetic Models during Target Controlled Infusion of Propofol
연구 목적 : 목표농도주입 시 약동학 매개변수는 안정된 혈중 농도를 유지하기 위해 주입속도를 결정하게 된다. 본 연구는 프로포폴의 한 약동학적 모델에 의한 혈장 및 효과처 예측 농도를 서로 다른 프로포폴의 약동학적 모델의 목표농도주입 시스템 자료를 사용하여 교차 분석하였다. 연구 방법 : 60명의 여성 환자를 무작위로 두 그룹으로 분류하여, 프로포폴의 혈중 목표 농도를 6.0 μgml-1로 설정하여 마취를 유도하였다. 그룹 M 은 Marsh 약동학 모델을 사용하였으며, 그룹 S는 Schnider 약동학 모델을 이용하였다. 2가지의 …
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