Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Pronucleotide"”.
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Development of chemical probes for intracellular nucleotide delivery, profiling of the metabolic fate(s) of nucleoside monoester phosphoramidates, and a nucleotide mimetic inhibitor of eIF4E
… utility of phosphate prodrugs, we have developed pronucleotide strategies that address the inefficiencies of the ProTide system. Chapter 2 describes the design and development of an anchimerically activated pronucleotide strategy, incorporating 2-(methylthio)ethyl and tryptamine as phosphate …
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Probing the HIV Reverse-Transcriptase enzyme with novel bifunctional HIV-1 RT inhibitors of the general formula (NRTI)-spacer-(NNRTI)
… flexible acyclic nucleotide phosphonate in a pronucleotide approach. A range of conclusions on the work are presented at the end.