Global ETD Search
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Showing 1 to 4 of 4 for “"Promoter Capture Hi-C"”.
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Investigation of transcription factor binding at distal regulatory elements
… remote regulatory elements, termed enhancers, which are brought into contact with promoters via DNA looping. Enhancers typically contain clusters of transcription factor binding sites, and TF recruitment to them is thought to play a key role in transcriptional control. In this thesis I have …
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Integrative statistical methods for the genomic analysis of immune-mediated disease
… In Chapters 2 and 3, I hypothesised that promoter-capture Hi-C (PCHi-C) data might have utility in physically linking disease-associated regulatory variants to their target genes, in a tissue-specific manner. To examine the genome-wide enrichment of GWAS summary statistics within PCHi-C …
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The interplay of global chromosomal organisation, promoter-enhancer interactions and transcription
All somatic cells within an organism contain the same genetic material, yet they display pronounced differences in function and morphology. Precise control of gene expression is of fundamental importance to allow cells to properly develop, maintain homeostasis, and respond to external stimuli. The …
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STUDIES OF B CELL DEVELOPMENT AND V(D)J RECOMBINATION
… separation of the recombination process, in which DH-JH precedes VH-DHJH recombination. Successful recombination of both heavy and light chain loci results in the expression of an antigen receptor on the cell surface. Subsequent selection stages remove non‑functional and autoreactivity …