Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 84 for “"Promiscuity"”.
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ENGINEERING PHAGE HOST RANGE PROMISCUITY
Bacteriophages, viruses that infect bacteria, are the most abundant biological entities on earth and one of the most potent evolution-driving forces in nature due to their capacity to facilitate horizontal gene transfer. Tailed bacteriophages have been studied intensively, and they rely on tail …
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Natural and Engineered Promiscuity Within the Enolase Superfamily
… is analogous to the stereochemical promiscuity engineered into the GlucD active site. The redesign of GlucD and the characterization of RspA illustrate the same type of promiscuity: syn and anti dehydrations in the same active site with different substrates, which results from proton …
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Functional discovery and promiscuity in the RuBisCO superfamily
… of novel functions as well as determination of promiscuity in the (RuBisCO) superfamily. To identify novel functions, novel sequences were targeted for cloning, purification, and assaying. This approach was used on sequences in the family homologous to R. rubrum RLP that has a published function …
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The role of enzyme promiscuity in plant metabolic evolution
… is to examine the mechanisms of enzyme promiscuity with regard to the expansion of plant specialized metabolism. First, we probed the structural and dynamic bases of substrate promiscuity hydroxycinnamoyltransferase (HCT), a member of the BAHD acyltransferase family, which has …
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Isothermal Titration Calorimetry Uncovers Substrate Promiscuity of Bicupin Oxalate Oxidase
<p>Oxalate oxidase from <em>Ceriporiopsis subvermispora</em> (CsOxOx) is a manganese-dependent enzyme that catalyzes the oxygen-dependent oxidation of oxalate to form two moles of carbon dioxide and one mole of hydrogen peroxide. CsOxOx is the first oxalate oxidase reported to have a two beta …
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The Effects of Premarital Sexual Promiscuity on Subsequent Marital Sexual Satisfaction
… the relationship between premarital sexual promiscuity and marital sexual satisfaction. The sample included 313 married males and females between the ages of 18-40 using data from the NHSLS survey, a United States national random sample. The dichotomous dependent variable combined measures …
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An examination of psychopathy, promiscuity, and other risky sexual behavior over time
… to examine the relation between psychopathy, promiscuity, and other risky sexual behavior. One hundred fifty-two delinquent youth between the ages of 11 and 18, were recruited for the study following contact with the juvenile justice system. Youth participated in four evaluations over two …
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The Myth of Promiscuity: Examining Black Male Sexual Narratives and Sexual Identity
… objectification of Black men, and their presumed promiscuity. While such topics are important, there is little qualitative research that looks at the complexity and emotionality of African American men’s sexual experiences. Using the theoretical research on black masculinity and sexuality as its …
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The promiscuity of freedom : development and governance in the age of neoliberal networks
… or what can become coded as relations of promiscuity. What brings these partnerships together and seduces such disparate actors into alliance isn't so much the promise of increased technology access. It is instead the promise of "freedom" and the opportunity for diversely situated subjects …
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Metallo-β-lactamase-like enzymes from non-pathogenic organisms: an illustration of functional promiscuity
… may provide essential clues about the functional promiscuity that may be inherent to the family of β-lactam-hydrolysing enzymes. It is thus essential to probe the catalytic mechanism of these enzymes in detail to gain insight into essential factors that control their reactivity. In Chapter 5 a …
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Identification of features contributing to binding promiscuity of small-molecule inhibitors for rapidly mutating targets
… of the other factors that contribute to binding promiscuity. This study investigated the key features which differentiate robust HIV protease inhibitors from susceptible HIV protease inhibitors by examining the interactions of certain known flat and nonflat binders with the different residues of …
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Catalytic promiscuity of two plant P450 enzymes: CYP725A4 from Taxus cuspidata and CYP71B102 from Isatis Tinctoria
… respectively. In this thesis, the catalytic promiscuity of CYP725A4 from Taxus cuspidata and CYP71B102 from Isatis tinctoria were investigated. CYP725A4 and CYP71B102 are involved in the biosynthesis of paclitaxel and indigo/indirubin pathways, respectively. CYP725A4 is known to catalyze the …
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The theatre of promiscuity : a comparative study of the dramatic writings of Wole Soyinka and Howard Barker
The word 'artist serves as a pivot to the major concerns of this study. Consideration of its application and meaning in relation to contemporary society facilitates a detailed exploration and analysis of selected dramatic writings by Wole Soyinka and Howard Barker. The comparative nature of this …
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On the origins of enzyme inhibitor selectivity and promiscuity: a case study of protein kinase binding to staurosporine
Protein kinases are important regulatory enzymes in signal transduction and in cell regulation. Understanding inhibition mechanisms of kinases is important for the further development of new therapies for cancer and inflammatory diseases. I have developed a statistical approach based on the Mantel …
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Unmasked : towards a restoration discourse of female libertinism
… Restoration double standard which linked male promiscuity to libertinism, and female promiscuity to prostitution. The emphasis is placed on assessing the sexual ideologies embedded in some of the literature of the period. The impact of socioeconomic status in shaping the contrasting identities …
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EVIDENCE EVALUATION IN BIOMEDICAL KNOWLEDGE GRAPHS FOR PHARMACEUTICAL DISCOVERY
… are (1) Badapple: Bioassay data associative promiscuity prediction learning engine, (2) TIGA: Target illumination GWAS analytics, and (3) KGAP: Knowledge graph analytics platform. Badapple employs empirical bioassay data from PubChem and the NIH Molecular Libraries Program to recognize …
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Investigating the evolution of cytochromes P450 involved in GA biosynthesis
… or AtKO) exhibits significantly greater promiscuity than does OsKO2. To further characterize this plasticity of AtKO, we determined the structure of the resulting products, whereas OsKO2 only hydroxylates its substrates on C19, AtKO reacts with labdane-related diterpenes of varied …
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STRUCTURE-FUNCTION STUDIES OF MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASES FROM GUT COMMENSAL BACTERIA
… that Minpps attack InsP6 with high positional promiscuity, unlike bacterial and fungal phytases which display high catalytic specificity. Site-directed mutagenesis was employed to further investigate the catalytic promiscuity of BtMinpp, mutagenizing its active site to mimic that of PhyA, a …
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Intrinsic Cleavage Inhibition by Thermophilic Type II-S Restriction Endonucleases
… These enzymes maintain complete cleavage promiscuity, allowing utilization in techniques such as Golden Gate assembly, Serial Analysis of Gene Expression (SAGE), and Restriction Endonuclease Protection, Selection, and Amplification (REPSA). However, laboratories generated evidence that …
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