Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 17 of 17 for “"Prolonged release"”.
-
Statistically Designed Spheronization and Scale-Up of Ibuprofen Microparticulates Using the Rotor Disk Fluid-Bed Technology: Coating for Prolonged Release and Hard Gelatin Encapsulation of Microparticulates
… with rotor-disk insert, for immediate and prolonged drug delivery. Feasibilty studies using ibuprofen: Avicel (RC-581; 50:50), sodium lauryl sulfate (1%) as surfactant and water as binder in FLM-15 Vector Flo-coater with 12" stainless-steel and waffle-disk inserts showed that amount of …
-
Development of Random Triblock Copolymer Based Nanoparticulate Formulation for Sustained Release of Macromolecules/Biologics in Treatment of Posterior Segment Ocular Diseases
… efficiency. In order to ensure sustained and prolonged release, nanoparticles were suspended in thermosensitive gel which acted as a secondary barrier. The second approach was combining the benefit of two technologies i.e. nanoparticle and liposome to formulate hybrid nanoparticles …
-
Gene-supplemented collagen-glycosaminoglycan scaffolds for nonviral gene delivery in articular cartilage tissue engineering
… inability to maintain therapeutic levels over prolonged times due to degradation or diffusion from the defect site. The goal of this thesis was to develop a method to employ type II collagen-glycosaminoglycan (CG) scaffolds for the nonviral delivery of the gene encoding for insulin-like growth …
-
Use of Aloe vera and Aloe marlothii materials as excipients in beads produced by extrusion–spheronization
… use of MCC in beads has its limitations such as prolonged release of drugs due to lack of disintegration. The aim of this study was to determine if Aloe vera and Aloe marlothii leaf materials can be used as excipients in the production of beads prepared by extrusion spheronisation. A 2³ full …
-
Coaxial Electrospinning of Synthetic/Natural Polymer Combinations for Controlled Release of Active Components in Biomedical Applications
… pharmaceutical ingredients due to solubility and release rate limitations. Coaxial spinning addresses these challenges by enabling precise control over release rates and properties. This research focuses on developing coaxial electrospinning processes, with a particular emphasis on incorporating …
-
Coaxial Electrospinning of Synthetic/Natural Polymer Combinations for Controlled Release of Active Components in Biomedical Applications
… pharmaceutical ingredients due to solubility and release rate limitations. Coaxial spinning addresses these challenges by enabling precise control over release rates and properties. This research focuses on developing coaxial electrospinning processes, with a particular emphasis on incorporating …
-
Controlled release in inhalation
… of spray drying to introduce controlled release vectors into dry powders for inhalation was investigated. The first experimental section highlights the use of leucine in producing highly respirable spray dried powders, with in vitro respirable fractions (Fine particle fraction, FPF: F < …
-
Design of Thermosensitive Hydrogel for Extended-Release of Praziquantel
… this study aimed to develop an extended-release thermosensitive hydrogel formulation that was applicable to the injectable administration. The praziquantel-loaded hydrogel formulation based on poloxamer 407 (20%, w/v) was prepared, and two strategies for modifications of poloxamer 407 …
-
Development of orthogonally crosslinked thiol-ene hydrogels for encapsulation of pancreatic beta-cells
… of amphiphilic βCD affords enhanced loading and prolonged release of curcumin, an anti-inflammatory drug candidate but with poor water solubility. In addition, bioactive peptide such laminin-derived peptide flanked with two cysteine residues could be readily incorporated through orthogonal …
-
Drug delivery strategies to overcome ocular hypertension
… palmitate displayed the most promising in vitro release profile over 28 days and was therefore tested in subsequent in vivo experiments. When dispersed in an in situ gelling hyaluronan-oxime hydrogel and injected into the subconjunctival space of the rat eye, the timolol palmitate CDA-hydrogel …
-
The Effect of Gonadotropin Releasing Hormone on Opsin Gene Expression and Spectral Sensitivity in Zebra Cichlid Fish (Metriaclima zebra).
… system of zebra cichlids (Metriaclima zebra) via prolonged release cholesterol implants and intubation was investigated using electroretinogram (ERG) recordings, quantitative real-time RT-PCR and in situ hybridization. Three week and ten week sampling periods were used in the intubation study. No …
-
Exploration of a doxorubicin-polymer conjugate in lipid-polymer hybrid nanoparticle drug delivery
… is a suboptimal method, often leading to burst release upon administration. This work explores the impact of incorporating the drug-polymer conjugate doxorubicin-poly (lactic-co-glycolic) acid (Dox-PLGA) into a lipid-polymer hybrid nanoparticle (LPN). The primary difference in using a …
-
Aging Exacerbates the Brain Response to a Peripheral Immune Stimulus
… elicit sickness behaviors. However, excessive or prolonged release of cytokines can cause severe behavior deficits and neurotoxicity. Because neurobehavioral deficits are exacerbated in elderly during peripheral infections, the goal of this dissertation was to investigate age-related changes in …
-
Functional characterization of Phosphodiesterase-4A in behavior and obesity
… behavior, and PDE4B is involved with anxiety and release of inflammatory factors from immune cells; however, the functional role that PDE4A plays in behavior was not known. The purpose of this dissertation was to characterize the functional role of PDE4A in behavior through the use of PDE4A KO …
-
Injectable hydrogels for the improved delivery of treatments in spinal cord injury
… over both material degradation and the triphasic release of model biomacromolecule drugs over a 5 to 35 day period. Favorably, these materials display fast and controllable gelation kinetics under physiological conditions as well as non-swelling hydrolytic degradation profiles making them …
-
EVALUATION OF HYDROLYTIC ENZYMES IN THE DESIGN OF ORAL DRUG DELIVERY SYSTEMS
… activity of the enzyme cellulase to improve the release performance of oral modified release dosage forms having as functional polymer hydroxypropyl methylcellulose (HPMC), a hydrophilic cellulose derivative which is substrate of the enzyme itself. Previous examples of the use of enzymes in drug …
-
The effect of nanoclays on the properties of aspirin modified enteric polymer prepared by hot-melt mixing
… This dissertation investigates two controlled-release drug delivery systems. The first system, namely the enteric matrix, contains an active pharmaceutical ingredient (API) and plasticizer in an enteric polymer while in the second system a nanoclay is added to the enteric matrix, to produce a …