Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 41 for “"Prolonged Survival"”.
-
Cytokine signaling control of naïve CD8⁺ T-cell homeostasis
… and ye cytokine signals for their homeostatic survival and proliferation, but differences in sensitivity to these homeostatic signals among T-cell clones have been generally attributed to differences in TCR specificity. This thesis describes the novel identification and characterization of …
-
Characterizing the Impact of Specific Genetic Mutations on Chemotherapy Resistance and the Efficacy of Oncolytic Viruses for the Treatment of Ovarian Cancer
… sensitivity in syngeneic in-vivo models. VSV∆M51 prolonged survival in syngeneic tumour- bearing mice with KRas, Trp53 and Pten mutations, including one tumour model that did not respond to carboplatin. Response to VSV∆M51 in-vivo was associated with activation of CD4+ and CD8+ T lymphocytes in …
-
Fibroblast Heterogeneity In Pancreatic Cancer Immunity
… CAFs were immune stimulatory and associated with prolonged survival in GEMMs. Meanwhile, FAP<sup>+</sup> CAFs were immunosuppressive and correlated with shortened survival in GEMMs. Altogether, we discovered that aSMA<sup>+</sup> and FAP<sup>+</sup> CAFs are distinct CAF populations with opposing …
-
Examine the role of minor splicing pathway in spinal muscular atrophy
… caused by deletions or mutations of one gene, Survival Motor Neuron (SMN). SMN is crucial in splicing processes for proper gene expression. Previous studies showed a significant decrease in the levels of minor splicing (U12 intron) snRNPs in SMA mice and a restoration of a U12 intron-containing …
-
The Cell-Essentiality of KAT7 in Acute Myeloid Leukemia
… cell line showed delayed disease progression and prolonged survival compared to those injected with the wild-type counterpart. The acetyltransferase activity of KAT7 is essential for MLL-fusion AML as the E508Q catalytic dead mutant is unable to sustain the leukemic programme. Using the …
-
The Effect of Leucogenenol on Classical Chemotherapy and Immunotherapy of Friend Virus Disease
… investigated. Three parameters of the disease, survival time, ratios of spleen and liver weight to total body weight and periodic differential counts of peripheral blood were studied and analyzed. Findings. Although Methotrexate significantly prolonged survival time in animals thus treated, the …
-
Human neural stem cells over-expressing Akt1 provide cytoprotection and functional recovery in mouse stroke model
… pathways involved in cell proliferation, growth, survival, apoptosis and glucose metabolism. A previous study has shown that transplanted human neural stem cells (hNSCs) selectively migrate to the brain and induce behavioral recovery in mouse intracerebral hemorrhage (ICH) stroke model. However, …
-
Atr-Mediated Cd47 and Pd-L1 Upregulation Restricts Radiotherapy-Induced Immune Priming and Abscopal Responses In Colorectal Cancer
… RSP in both irradiated and abscopal tumors and prolonged survival in three distinct murine CRC models, including a cecal orthotopic model. In murine CRC, αSIRPα exerts superior tumoricidal efficacy versus αCD47 in combination with radiotherapy and αPD-1. We find RSP efficacy to be highly STING …
-
Living with locally advanced rectal cancer: an exploration of the everydayness of living with rectal cancer
Advances in treatment and prolonged survival times mean that increasingly individuals are living with advanced cancer, yet services remain disease orientated. This thesis has documented the process of undertaking a longitudinal qualitative study to explore the everydayness of living with locally …
-
Enhancing Oncolytic Virotherapy Using Functional Genomic Screening
… virus significantly delayed tumour progression, prolonged survival and resulted in durable responses. As a parallel approach to enhancing the therapy, we also sought to discover alternative means of conferring VV tumour specificity that would lead to a larger therapeutic index than that of the …
-
CD166 modulates disease progression and osteolytic disease in multiple myeloma
… cells showed delayed disease progression and prolonged survival compared to mice receiving mock transduced cells. To examine the potential role of CD166 in osteolytic lesions, we first used a novel Ex Vivo Organ Culture Assay (EVOCA) which creates an in vitro 3D system for the interaction of …
-
Antioxidant Biomarkers and Nutraceutical Therapeutics in Neurodegeneration and Neurotrauma
… When administered at symptom onset, PCA prolonged survival, improved motor function, reduced gliosis, and offered significant neuroprotection in hSOD1G93A mice.</p> <p>It is hypothesized that rmTBI results in an increased oxidative stress burden and subsequent antioxidant depletion. These …
-
Non-specific aortic arteritis (Takayasu's disease) : the Cape Town experience
… number of patients have "burnt out" disease, and prolonged survival has been observed.
-
Targeting the Notch-1/IGF-1R/Akt Axis in at Orthotopic Model of Advanced Non-Small Cell Lung Cancer
… results indicate that Notch-1 provides necessary survival signals to NSCLC cells by positively regulating IGF-1R to activate the Akt-1 pathway. Therefore, the overall hypothesis is that an inhibitor of Notch activation, such as γ-secretase inhibitor (GSI) MRK-003; or a fully humanized antibody …
-
The role of host and microbial factors in the pathogenesis of chronic schistosomiasis in mice
… in relation to control wild type mice. The prolonged survival and reduced immunopathology were diminished by treatment with α-CD8 antibody highlighting the significance of CD8-expressing immune mediators during chronic Schistosomiasis. Transfer of the altered intestinal microbiota from …
-
GENERATION OF SYNTHETIC ANTIBODIES AS POTENTIAL THERAPEUTICS TO BLOCK IL3–MEDIATED INNATE IMATINIB RESISTANCE IN CHRONIC MEYLOID LEUKEMIA
… anti–IL3Rα and anti–IL3Rβ antibodies showed a prolonged survival of C57BL/6 mouse models that received antibody–treated CML cells. Encouraged by anti–leukemic activity of anti–IL3Rα and anti–IL3Rβ antibodies on CML cells, we used our novel antibodies to engineer anti–IL3Rα–IL3Rα and …
-
Evaluation of Altered Kras Codon Bias and NOS Inhibition During Lung Tumorigenesis
… was provided in the water and continued until survival endpoints. In this model, L–NAME treatment decreased tumor growth and prolonged survival. These data establish a potential clinical role for NOS inhibition in lung cancer treatment.</p>
-
Characterizing and targeting the genomic consequences of ATRX deficiency in glioma
… treatment profoundly delayed tumor growth and prolonged survival exclusively in mice bearing ATRX-deficient GSC flank xenografts. Histopathological analyses revealed decreased proliferation, increased apoptosis, and significant induction of G4s, replication stress, and DNA damage in …
-
A cohort study of sex differences and prognostic biomarkers in colorectal cancer
… of a series of putative biomarkers with survival, treatment response and clinicopathological factors in a large cohort of incident CRC, with special attention to sex differences. The study group consisted of tumours from 557 incident cases of CRC in the Malmö Diet and Cancer Study (MDCS). …
-
Candida Albicans Als5p Amyloid In Host-Microbe Interactions: A Ceanorhabditis Elegans Study
… Our studies showed that CED-1 was necessary for prolonged survival in the presence of Als5p, and TOL-1 was required for death in C. elegans fed S. cerevisiae. We have further demonstrated the necessity of CED-1 and TIR-1 in phosphorylation of ERK-2/MPK-2. The SAM and TIR domains of TIR-1 were …
Page 1 of 3