Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"Proliferation assay"”.
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Adoptive transfer of immunity to rabies virus
… with CVS-27 rabies virus, by the lymphocyte proliferation assay and by the indirect leucocyte migration inhibition assay;Efficacy studies based on mortality data were inconclusive. Transfer factor may have been responsible for the resistance observed in some experiments. Resistance appeared …
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Sythesis and Biological Screening of a Series of Novel Chemokine Receptor CCR5 Antagonists
… CCL5 was measured in the calcium mobilization assay as an indication of its CCR5 receptor antagonism. The anti-proliferation assay was performed to measure the ability of these new compounds to inhibit the proliferation of prostate cancer cell lines, PC-3 and M12. A new lead compound has been …
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SYNTHESIS AND BIOLOGICAL EVALUATION OF SECOND GENERATION ANIBAMINE ANALOGUES AS NOVEL ANTI-PROSTATE CANCER AGENTS
… the original synthetic route. While cytotoxicity assay proved the compounds to be non toxic to normal cells, anti-proliferation assay displayed that having a bulky, hydrophobic group in the side chain of the parent compound is essential for the activity. Looking at this data, the third generation …
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CD147 AS A POTENTIAL THERAPEUTIC TARGET IN GLIOBLASTOMA TREATMENT
… monoclonal antibodies. An apoptosis/necrosis assay suggests that GBM cells treated with anti-CD147 monoclonal antibodies were not experiencing a form of induced cell death. Rather, our cell proliferation assay results suggest that anti-CD147 monoclonal antibody treated cells had significantly …
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Novel anti-endothelial therapeutic strategies in malignant melanoma : the metronomic approach.
… endothelial cells and cancer cells using an MTT proliferation assay. Results confirmed significant (p
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Solid Phase Synthesis and Biological studies on metal conjugates of bioactive peptides for targeted delivery
… in concentrations up to 1mM in the WST-1 proliferation assay. In case of the metallocene-TAT bioconjugates, the ferrocene moiety plays a role in the escape of the conjugate from the endosomes, which is an advantage because the utility of TAT peptide as a vector for cellular delivery is …
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Mapping the immunological receptors CD14 and macrophage receptor with collagenous structure (MARCO) and their innate recognition potential on trophoblast cells: relevance for human pregnancy
… growth factor (VEGF), and the decreased cell proliferation of trophoblast cells upon treatment with LPS. Myoferlin and VEGF quantification estimated by flow cytometry and western blotting showed significant decrease in LPS treated JEG-3 cells in time and dose dependent manner. The cell …
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Etablierung adenoviraler Genexpression zum antifibrotischen Einsatz bei der Leberfibrose
… the biological activity was confirmed by proliferation assay.
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Identification and evaluation of the bioactive peptide QUB-2925 from the defensive skin secretion of Phyllomedusa tomopterna
… (MALDI-TOF MS). In broth microdilution assays, QUB-2925 showed significant antimicrobial activities against the Gram-negative bacterium, Escherichia coli (E. coli ATCC CRM8739) at 1 µM, the Gram-positive bacterium, Staphylococcus aureus (S. aureus ATCC CRM6538) at 2 µM and the yeast, …
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Studies on the efficient intracellular delivery vehicle using variable region domain of a cell-penetrating anti-DNA monoclonal antibody
… and confocal microscopic analysis and cell proliferation assay were used. The VH domain penetrated into all cell lines we tested in time- and dose-dependent manner, although the internalization efficiency was varied. We also found that the VH domain was localized in nuclei as well as …
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Comparison of immune responses induced by Bacillus calmette-Guerin when given at birth or at 6 weeks of age in Ugandan Infants
… blood intracellular cytokine/cytotoxic marker assay to measure T cell-associated cytokine expression and memory phenotypes. We also compared the capacity of BCGspecific T cells to proliferate and produce cytokines upon antigenic stimulation with a 6-day proliferation assay. Finally, we measured …
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Analysis of trafficking dynamics and cellular response in the interleukin-2 ligand/receptor system
… to exhibit increased bioactivity in a T cell proliferation assay. Dedicated trafficking studies show that endocytic trafficking of this 20 I variant might be responsible for this increased potency, as a significantly increased fraction of internalized 201 is sorted to recycling instead of to …
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Molecular Basis of Upregulation of IL-17 in Estrogen Model of Inflammation
… Tc17 cells. This is possibly due to increased proliferation of CD8⁺ cells from estrogen-treated mice, as demonstrated by CFSE cell proliferation assay. Furthermore, estrogen also enhances the ability of IL-17-target cells to release proinflammatory molecules when exposed to IL-17. Together, …
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Use of the Immune System to Investigate the Toxicity Induced by Environmental Pollutants in Fish, Amphibian, and Mammalian Species
… system was detectable using mitogen-induced proliferation assay and cell-mediated toxicity assay. Fish from various streams of the Roanoke River were tested for immunotoxicity and parasitic infection. Fish from the more polluted North Fork of the Roanoke River exhibited a stronger mitogenic …
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FRK cancer-related mutations: Effect on enzymatic activity and cellular processes
… and increased kinase activity respectively. Proliferation, migration and invasion assays were also performed with the R64P, K265R, N358I and VF mutations. The proliferation data revealed that the cell line expressing wild type FRK reduced cell growth which is consistent with past findings. …
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Discovery of multi-omics biomarkers for toxicity using meta-analysis
… model 20 3-2. Cell culture 20 3-3. Cell proliferation assay 20 3-4. mRNA isolation, semi-quantitative RT-PCR, and qRT-PCR 21 3-5. In vitro validation of the SMOT genes 21 3-6. GO and protein network analysis of the SMOT genes 22 Ⅲ. RESULTS 23 A. Data preparation & class assignment 23 1. …
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Equine Protozoal Myeloencephalitis. Preliminary Investigation of Protozoan-Host interactions in the horse
… were the only cells that showed a decreased proliferation (p<0.05). A difference between EPM affected and control horses could not be detected (p>0.05). These results may imply that the persistence of S. neurona infection in the horses CNS is, in part, due to a pathogen-derived mechanism that …
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Phosphorylation of the Estrogen Receptor Alpha (ERα) at Serine 118 by Phospho-p44/42 MAPK and Regulation by Estrogen and Progesterone in Human Uterine Leiomyoma Tissue and Cells
… cycle. <em>In vitro</em> studies to assess proliferation of uterine leiomyoma (UtLM) and uterine smooth muscle (UtSMC) cells and expression of ERα-phospho-Ser118 and phospho-p44/42 MAPK were done using western blotting and a cell proliferation assay, respectively, alter treatment with …
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The Effect of Radiation and Repeated Sub-culturing on TGF-β1 Signaling in FRTL-5 Cells
… in cellular growth rate using the MTS cell proliferation assay. TGF-β1 ligand and receptor levels were quantified via ELISA, immunocytochemistry and western blot analysis respectively. The levels and activity of Smads 2, 3, 4 and 7, downstream effectors in the TGF-β1 signaling pathway were …
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Effects of psychoactive trace minerals on glial cell development in vitro.
… with lithium to affect glioblastoma cell proliferation, function and viability in vitro. Two different glioblastoma cell lines (U87M0 and 132 1N1) were cultured in media containing different concentrations of either zinc or copper above and below the physiological range (0.02 to 10 mgIL …
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