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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Proliferating cell nuclear antigen"”.
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Discovery of Molecules that Modulate Protein-Protein Interactions in the Context of Human Proliferating Cell Nuclear Antigen-Associated Processes of DNA Replication and Damage Repair
Integral to cell viability is the homotrimeric protein complex Proliferating Cell Nuclear Antigen (PCNA) that encircles chromatin-bound DNA and functionally acts as a DNA clamp that provides topological sites for recruitment of proteins necessary for DNA replication and damage repair. PCNA has …
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Combination of Dietary Tomato and Broccoli Powders Are Effective Growth Inhibitors of Dunning R3327-H Prostate Adenocarcinomas
… and increased apoptosis, as quantified by Proliferating Cell Nuclear Antigen (PCNA) immunohistochemistry and the ApoptagRTM assay, respectively. Utilizing real time polymerase chain reactions (RT-PCR) and the SYBR Green assay, mRNA was quantified in the liver, prostate, and tumors. …
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Analysis of Interphase Chromatin Motion in HeLa Cells
… interphase chromatin mobility in the cell nucleus. Interphase chromatin undergo replication prior to cell division with the assistance of replication proteins (machinery) which modify chromatin mobility. Using dual color imaging of flourescently tagged chromatin and proliferating cell …
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The effects of tributyrin and butyrate on equine skeletal muscle
… Tributyrin and butyrate affect satellite cells and oxidative metabolism in other species. To assess the effects of tributyrin on equine muscle repair, Thoroughbred horses were supplemented tributyrin, and a submaximal exercise test was performed. RNA isolated from the gluteal muscle of …
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Application of Femtosecond lasers in confocal and scanning tunnelling microscopy
… induce DNA damage in the nuclei of live cells by multi-photon absorption, the development and comparison of foci counting algorithms for the quantitative assessment of radiation damage and work towards the development of an ultrafast Scanning Tunnelling Microscopy (STM) technique, …
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Molecular and Biochemical Analyses of a Three-Subunit Euryarchaeal Clamp Loader Complex
… In eukaryotes, the ring-shaped sliding clamp, proliferating cell nuclear antigen (PCNA), encircles double-stranded DNA within its central hole and tethers the DNA polymerases onto DNA. A spiral-shaped pentameric protein, replication factor C (RFC), functions as the clamp loader, which installs …
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RAD6-abhängige DNA-Reparatur wird durch Ubiquitin- und SUMO-Modifikation von PCNA reguliert
… sind bisher allerdings wenig verstanden. PCNA (Proliferating Cell Nuclear Antigen)ist eine zentrale Komponente der DNA-Replikation und DNA-Reparatur.Im Rahmen dieser Arbeit konnte gezeigt werden,daß PCNA über drei verschiedene posttranslationale Modifikationen reguliert wird.In der S-Phase des …
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Comparative Studies of Processivity Clamp Loader ATP Site Function
… factor C (RFC) loads the processivity clamp, proliferating cell nuclear antigen (PCNA), onto DNA. ATP binding to RFC activates a γ-phosphate sensor in ATP site C that promotes DNA association by RFC-PCNA. DNA binding to the RFC-PCNA complex then triggers the ATP hydrolysis cycle which starts …
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Estrogenic Effects of Genistein in Ovariectomized Gilts
… percentage (P < 0.01). Height of epithelial cells lining the uterine glands and the lumens of the uterus and cervix was increased when treated with 400-mg/day genistein or estradiol (P < 0.01). Immunohistochemical staining was positive in all tissues stained for proliferating cell nuclear …
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The Effects of Lead Toxicity on Thyroid Hormone Physiology in the Developing Brains of Xenopus laevis Tadpoles
… of the effect of Pb on tectal size and cell death in the developing brain yielded bimodal changes that depended upon Pb concentration in both features. Furthermore, Pb impaired TH-induced changes in brain development, including neurogenesis and brain volume. Pb abolished the T4-mediated …
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The role of UBZ1 in PCNA-dependent DNA damage response
… several sources of damage that can alter the cell's genomic material. DNA damage can be caused by exogenous agents, like radiation and toxins or by endogenous factors, like Reactive Oxygen Species (ROS), produced during normal oxygen metabolism. in order to guarantee cell survival and the …
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Phosphorylation of the Estrogen Receptor Alpha (ERα) at Serine 118 by Phospho-p44/42 MAPK and Regulation by Estrogen and Progesterone in Human Uterine Leiomyoma Tissue and Cells
… protein kinase (phospho-p44/42 MAPK), and proliferating cell nuclear antigen (PCNA) in human leiomyoma and myometrial tissues during the proliferative and secretory phases of the menstrual cycle. <em>In vitro</em> studies to assess proliferation of uterine leiomyoma (UtLM) and uterine …
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Cell proliferation and metal accumulation in the subventricular zone and olfactory bulb in Parkinson’s disease
… brains. There was no change in the number of cells expressing proliferating cell nuclear antigen (PCNA) or the D1 or D2 dopamine receptor subtypes in PD, suggesting that olfactory dysfunction in PD is not caused by a decrease in subventricular zone cell proliferation. However, these studies …
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Biological and biochemical characterization of the extracellular signal-regulated kinase 8 homolog (TbERK8) in Trypanosoma brucei
… a three-tiered signaling cascade that regulates cell responses to stimuli and are involved in essential processes. MAPKs can regulate differentiation, virulence, apoptosis, cell cycle and gene expression, which makes MAPKs interesting drug targets in T. brucei. The extracellular-signal regulated …
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Characterisation of oestrogenic properties of Isoflavones derived from Millettia griffoniana Baill.: - Molecular mode of action and tissue selectivity
… gene assay based on stably transfected MCF-7 cells (MVLN cells) and the induction of alkaline phosphatase in Ishikawa cells. The oestrogenic activities of isoflavones from Millettia griffoniana could be completely suppressed by the pure oestrogen antagonist, fulvestrant. The expression of …
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The role of retinoids in the regeneration of the axolotl spinal cord
… has been described in juvenile Axolotl ependymal cells. Retinoid effects may possess a significant role in the regeneration-permissive interaction of the meninges and ependyma of the Axolotl spinal cord after penetrating injury. During spinal cord regeneration in urodele amphibians, the pattern of …
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Replication-associated base excision repair Of oxidized bases in the mammalian genome
… including Replication Protein A (RPA), Proliferating Cell Nuclear Antigen (PCNA), Flap Endonuclease 1 (FEN1), DNA Polymerase ä, Replication Factor C (RFC), and DNA Ligase I as well as the stress responsive Rad9-Rad1-Hus1 (9-1-1) DNA sliding clamp. We mapped the overlapping binding sites …
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Suppression of Carcinogenesis and Tumor Progression by an Energy Restriction-Mimetic Agent in Murine Models of Prostate Cancer
Cancer cells preferentially utilize glycolysis to generate energy even in the presence of sufficient oxygen for oxidative phosphorylation. This shift in energy metabolism, termed the Warburg effect, is responsible for cancer cells’ high metabolic rate. Therapies that inhibit cancer cell energy …
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The Role of Bone Morphogenetic Protein Signalling in Adult Lung Health and Disease
… in the establishment of correct epithelial cell distribution throughout the airways. In the adult lung, BMP signalling is reactivated during airway injury and inflammation and there is evidence of aberrant signalling in lung cancer and in chronic lung diseases such as asthma and fibrosis. …
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