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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 227 for “"Prokaryotic"”.
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Studies on Prokaryotic and Eukaryotic Polynucleotide Ligases
Made available in DSpace on 2014-12-14T07:14:45Z (GMT). No. of bitstreams: 1 7714926.pdf: 4224938 bytes, checksum: 8727bde8d854483297215c784ed8faf6 (MD5) Previous issue date: 1977
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Methods for Analysis of Prokaryotic Genome Architecture
… methods for identifying patterns in prokaryotic genome construction through a mapping of genomic features, using semantic similarity, independent of a particular corpus to better approximate functional similarity. We also present an algorithm for creating whole genome multiple …
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Efficient algorithms for gene cluster detection in prokaryotic genomes
… machines. Also these sequences, mostly prokaryotic ones, are well annotated, which means that the positions of their genes and parts of their regulatory or metabolic pathways are known. A new task in the field of bioinformatics now is to gain gene or protein information from the …
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Genetic and Computational Tools for Engineering Complex Prokaryotic Systems
Prokaryotic systems are promising platforms for bioproduction, but the complexity of their gene regulatory and metabolic networks presents significant challenges for engineering efficient biosynthetic pathways. While CRISPR-Cas technologies have revolutionized genome editing in eukaryotes, the …
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Novel Cell Surface Anchoring Mechanism Of Prokaryotic Secreted Protein
… are conserved among diverse organisms of both prokaryotic domains, data obtained from my work will also serves as foundation for future studies of cell surface anchoring in other archaea and bacteria.
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"Effects of nonthermal plasma on prokaryotic and eukaryotic cells"
… physiology. Plasma-mediated germicide in prokaryotic cells and stimulatory and proliferative effects in eukaryotic cells were determined to be dose-dependent phenomena.
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Efficient Algorithms for Prokaryotic Whole Genome Assembly and Finishing
<p>De-novo genome assembly from DNA fragments is primarily based on sequence overlap information. In addition, mate-pair reads or paired-end reads provide linking information for joining gaps and bridging repeat regions. Genome assemblers in general assemble long contiguous sequences (contigs) …
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Molecular Investigations of Protein Assemblies Involved in Prokaryotic Virulence
… complexes mediate a diverse range of behavior in prokaryotic cells, yet the exact molecular mechanisms explaining how many of these complexes assemble and function remain unknown. This work focuses on understanding the molecular mechanisms of two different protein assemblies responsible for …
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Investigating asparagine-linked protein glycosylation in eukaryotic and prokaryotic systems
N-linked protein glycosylation is characterized by the formation of a -glycosylamine linkage to an asparagine residue within the Asn-Xaa-Ser/Thr consensus sequence. This modification is found in organisms from eukaryotic, archaeal and bacterial domains and is implicated in numerous cellular …
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Recombination and Excision: DNA Repair Proteins in Prokaryotic Host-Virus Conflicts
… immune and counter-immune functions in prokaryotic host-virus genetic conflicts. CRISPR-Cas adaptive immune systems, found in nearly half of all bacteria, use sequence-specific guide RNAs to cleave the genetic material of infecting phages. Bacteria and some phages encode recombination …
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The Structure and Evolution of The Prokaryotic 23s Ribosomal Ribonucleic Acid
Made available in DSpace on 2014-12-14T07:14:48Z (GMT). No. of bitstreams: 1 7913621.pdf: 4198618 bytes, checksum: 48053060e4eed5ce5512a7543ceaa279 (MD5) Previous issue date: 1978
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Modeling Genome Organization in Eukaryotic and Prokaryotic Cells Using Folding Determinant Interactions
The three-dimensional organization of genomes is fundamental to gene regulation, DNA replication, and cell identity. A key challenge, however, lies in disentangling stochastic folding driven by polymer physics from specific interactions mediated by nuclear landmarks and regulatory factors. In this …
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CPISPR-CAS: From a Prokaryotic Immune System to a Gene Editing Tool
… Secondly, I developed a tool to manipulate prokaryotic genomes and gene expression by using an engineered type II CRISPR-Cas system. To date, all three types of CRISPR-Cas systems target DNA. Type III CRISPR-Cas immunity displays an elaborate targeting mechanism and distinguishes itself from …
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Novel Sequence-Based Method for Identifying Transcription Factor Binding Sites in Prokaryotic Genomes
… available sequence data in order to determine prokaryotic transcription factor binding specificities. The prototypical prokaryotic transcription factor: TF) contains a helix–turn–helix: HTH) fold and bind DNA as homodimers, leading to their palindromic motif specificities. The …
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Post-translational generation of Cá-formylglycine in Prokaryotic Sulfatsases by Radical SAM-Proteins
Ca-formylglycine ist der katalytische Überrest von sulfatases. FGly wird durch posttranslational Änderung eines Cysteine (Pro- und Eukaryotes) oder des Serins (prokaryotes) gelegen in konserviert erzeugt (C/S)xPxR Motiv. AtsB, ein vorausgesagtes radikales SAM Eisen-Schwefel Protein, ist ein …
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Exploring Prokaryotic Thiamin Biosynthesis: Mechanistic Studies On Thiamin Thiazole Synthase And Pyrimidine Synthase
… We were able to study the last few steps on the prokaryotic thiamin thiazole pathway in greater detail, and elucidate the structure of the final product of the thiazole synthase to be the thiazole tautomer phosphate. We were also able to assign function to a gene involved in aromatization of the …
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Mechanistic studies on transcription activation via DNA looping in a prokaryotic promoter-enhancer system
… transcription activation was studied in a prokaryotic promoter-enhancer system. It comprises the E. coli RNA polymerase, which is associated with the alternative sigma factor sigma54 (RNAP-sigma54), and the transcription activator protein NtrC (nitrogen regulatory protein C), which binds to …
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Quantifying effects of substrata chemomechanical properties on eukaryotic and prokaryotic cell adhesion and morphology
… cells and fibroblasts; and the adhesion of prokaryotic cells S. epidermidis and E. coli are presented. Endothelial cells (EC) comprise a major portion of the cell population in the human body. Because of the extensive distribution of endothelial cells in various tissues, they function across …
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