Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Proinflammatory Mediators"”.
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Novel Mechanisms Underlying the Inflammatory Effects of Leptin and Low Dose Endotoxin
… underlying the involvement of these two mediators is not clearly understood. The purpose of this study is to understand the mechanism underlying inflammatory complications caused by leptin and low dose endotoxin most recently coined metabolic endotoxemia. Interleukin-Receptor Associated …
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Neutrophil Responses to Mixed-Species Anaerobic Biofilms
… tissue damage due to the overproduction of proinflammatory mediators. The objective of this project was to generate mixed-species anaerobic biofilms composed of two opportunistic pathogens, Fusobacterium necrophorum and Porphyromonas levii and measure neutrophil responses. Neutrophils are a …
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Transient receptor potential vanilloid 1 exhibits neuroprotective effects in LPS-induced dopaminergic neuronal death in the suabstantia nigra in vivo.
… that CAP attenuates LPS-induced production of proinflammatory mediators such as inducible nitric oxide synthase (iNOS) and ROS while CAP increases Arginase 1 and CD206, M2 macrophage markers. In addition, CAP protected nigral DA neurons from LPS-induced neurotoxicity. This neuroprotective …
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Protective Mechanism of Epigallocatechin-3-gallate against Helicobacter pylori- induced Gastric Epithelial Cytotoxicity via Blockage of TLR-4 Signaling
… signaling by EGCG attenuated the synthesis of proinflammatory mediators, HETEs. EGCG pretreatment showed significant cytoprotective effects against H. pylori-induced gastric cytotoxicity via interference of TLR-4 signaling induced by H. pylori. Thus, our result implies that continuous intakes …
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Mise en évidence du rôle physiologique de la chimiokine CCL2 dans la neurotransmission nociceptive au niveau spinal
… spinally blocking CCR2 limited the expression of proinflammatory mediators. It also reduced peripheral inflammation by preventing peripheral transport of SP. We then translated our findings in a model of arthritic pain, closer to the clinical reality of patients with rheumatoid arthritis. Spinal …
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The Eosinophil Granular Leukocyte; Source and Target of High Mobility Group Protein B1
… in which they participate through the release of mediators. Eosinophils thereby function as effectors and immunoregulators and contribute to inflammation-associated disease symptoms. The high mobility group protein B1 (HMGB1) was discovered in the nuclear fraction of non-activated peripheral blood …
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Hormone-Sensitive Lipase - New roles in adipose tissue biology
… of macrophages triggers the release of proinflammatory mediators from WAT e.g. tumor necrosis factor alpha, causing systemic inflammation precipitating in insulin resistance. Thus, in addition to its key role in energy homeostasis, HSL appears to play an important role by providing …
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VALORIZATION OF CHESTNUT BY-PRODUCT FOR GASTROINTESTINAL HEALTH
… by-products (50 μg/mL) inhibited the release of proinflammatory mediators (CXCL-10, IL-8, MCP-1, ICAM-1), along with the NF-κB-driven transcription, and induced the HRE-driven transcription. In AGS and GES-1 cells stimulated with TNFα (10 ng/mL) or infected with H. pylori, the external part of …
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Monocyte adherence to fibronectin: role of CD11/CD18 integrins and relationship to other monocyte functions
… all of the monocyte subpopulations. In contrast, proinflammatory mediators up-regulated a1-antitrypsin accumulation by only the spontaneously adherent cells, probably by translational or post-translational mechanisms. In conclusion, these data indicate that monocytes are heterogeneous in their …
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Studies on the Cellular Responses and Roles of Microglia, Astrocytes, and Blood-Derived Inflammatory cells in Injured Rat Brain
… but negligible expression of pro-inflammatory mediators such as TNF-α, IL-1β and iNOS. Accordingly, recovery of impaired astrocytes, endothelial cells, and neuronal cells occurred after monocytes infiltrated. These results indicate that monocytes play important roles to repair of the injured …
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An Investigation for Genetic Susceptibility to Type 1 Diabetes Mellitus and its Microvascular Complications
… promotes the transcription of a wide array of proinflammatory mediators and adhesion molecules. HSPs are proposed to have a cytoprotective effect; in contrast they have the capacity to promote pathogenic processes. In this study, polymerase chain reaction (PCR)-based microsatellite analysis and …
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Limitierte Proteolyse endothelialer und epithelialer Oberflächenmoleküle durch die Metalloprotease ADAM17
… proteoglycans that bind and present various proinflammatory mediators. Syndecan-1 and -4 are expressed on lung epithelial cells and a soluble form is released into the bronchoalveolar fluid during inflammation. The results presented here show that cell lines and primary cells of human …
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Role of Cerebral Vasculature and Effect of Circulating Exosomes in Propagation of Systemic Inflammatory Responses into the Central Nervous System
… CNS and that they are the most likely source of proinflammatory mediators that could further initiate glial cell activation. This is further followed by the activation of apoptotic signaling in the CECs which is known to lead to blood brain barrier (BBB) disruption and allow the peripheral …
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Analyse der inflammatorischen Potenz mikro- bis nanostrukturierter Materialoberflächen auf primäre humane Makrophagen
… an intermediate phenotype with both anti- and proinflammatory properties. To determine the activation state of the macrophages on the different topographies the concentrations of inflammatory mediators in the culture supernatant were measured. Some proinflammatory mediators like IL-1β, CCL2 and …
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Neural and Behavioural Consequences of Chronic Inflammation following Spinal Cord Injury
… in changes in critical neuroactive compounds. Proinflammatory mediators have been shown to up-regulate the enzyme indoleamine 2,3 dioxygenase (IDO) resulting in the accelerated degredation of serotonin precursor tryptophan (TRP) and increased production of TRP metabolites such as kynurenine …
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Anti-inflammatory and anti-colon cancer potential of yerba mate (Ilex paraguariensis St. Hilaire) bioactive constituents
… (54.5% inhibition) and COX-2 (56.6% inhibition) proinflammatory mediators and β-catenin pathways by increasing GSK-3β activity (41.1% induction) suggesting its potential preventive role. Mate saponins did not reduce the number of ACF (p > 0.05), but significantly suppressed iNOS and COX-2 …