Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Progressive supranuclear palsy"”.
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Progression and variation of Progressive Supranuclear Palsy
Progressive supranuclear palsy (PSP) is a devastating neurodegenerative disorder with poor prognosis. The development of novel therapeutics has been hindered by long delays from symptom onset to diagnosis, marked heterogeneity, and uncertainty over the optimal outcomes in early-phase clinical …
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Synaptic loss in the primary tauopathies of Progressive Supranuclear Palsy and Corticobasal Degeneration
… dysfunction in the primary tauopathies of Progressive Supranuclear Palsy (PSP) and Corticobasal Degeneration (CBD). Both PSP and CBD are associated with an accumulation of 4-repeat tau in cortical and subcortical areas. As well as movement disorders, they impair cognitive function, even …
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The role of tau and neuroinflammation in Progressive Supranuclear Palsy and Alzheimer's Disease
… extent of tau pathology and neuroinflammation in Progressive Supranuclear Palsy (PSP) and Alzheimer’s disease (AD) ‘in vivo’ and to validate it using post mortem data is critical to develop reliable biomarkers for these disorders, and for tracking the effects of clinical trials using …
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Digitally quantified neuropathological correlates of structural and functional imaging biomarkers in progressive supranuclear palsy
… between different tauopathies. With this, progressive supranuclear palsy (PSP) is a prime disease for investigating the relationship between imaging changes and tau burden. Early studies have revealed that semi-quantitative pathological tau measures are predictive of *in vivo* atrophy but …
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Imaging Correlates of Heterogeneity in the Syndromes Associated with Frontotemporal Lobar Degeneration
… and from two multi-site collaborations, the Progressive Supranuclear Palsy Corticobasal Syndrome Multiple System Atrophy Longitudinal Study UK (PROSPECT-M-UK) and the Genetic Frontotemporal Dementia Initiative (GENFI). I describe characteristic differences in markers derived from task-free …
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Apathy and Impulsivity in Frontotemporal Lobar Degeneration Syndromes
… syndromes, including frontotemporal dementia, progressive supranuclear palsy and corticobasal syndrome. They cause substantial patient morbidity and carer distress, often coexist and are undertreated. Using data from the Pick’s disease and Progressive supranuclear palsy Prevalence and INcidence …
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Characterization of Tau Oligomeric Strains: Implications for Disease Phenotypes
… I found that toxic tau oligomers are elevated in progressive supranuclear palsy, traumatic brain injury and synucleinopathy models and reversal of toxicity can be achieved with treatment of a tau oligomer-specific monoclonal antibody. Tau oligomers have prion-like properties, enabling them to seed …
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Genetic Characterisation of Neurodegenerative disorders
… disease (AD), Parkinson's disease (PD), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). On strong evidence that several genes may influence the development of sporadic neurodegenerative diseases, the genetic association approach was used in the work of this …
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Amyloid seeding assays for the selective amplification of tau aggregates from human brain homogenates
… (3R, Pick's disease, PiD), four repeats (4R, Progressive supranuclear palsy, PSP; corticobasal degeneration, CBD; others), or a combination of 3R/4R tau aggregates (Alzheimer disease, AD; chronic traumatic encephalopathy, CTE; primary age-related tauopathy, PART). This work details several …
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Behavioural disinhibition in the syndromes associated with frontotemporal lobar degeneration
… the nonfluent and semantic variants of primary progressive aphasia, progressive supranuclear palsy and corticobasal syndrome. Multivariate analyses of clinical features and brain morphometry identified components that showed considerable overlap across the diagnostic groups. The transdiagnostic …
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Connectivity biomarkers in neurodegenerative tauopathies
… movement and cognition. In this thesis I study Progressive Supranuclear Palsy (PSP) and the Corticobasal Syndrome (CBS), two parkinsonian disorders associated with accumulation of hyperphos- phorylated and abnormally folded tau protein. I contrast these two disorders with Parkinson’s disease …
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Structural Polymorphism in Tau Filaments: An Implication for Neurodegenerative Diseases
… Alzheimer's disease, Pick's disease, and progressive supranuclear palsy. In the adult human brain, six isoforms of tau are expressed that differ by presence or absence of the second of the four semiconserved repeats. As a consequence, half of the tau isoforms have three repeats (3R tau), …
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Myasthenia Gravis mimics: An audit of cases identified at Groote Schuur Hospital over 20 years
… definite or probable muscular dystrophy (MD), 1 progressive supranuclear palsy and 1 with a multiple sclerosis brainstem relapse. Median age at symptom onset was 10 years for CMS, 18 for mitochondrial cytopathies, 53 for FNS, 58 for the muscular dystrophy cases and 63 years for those with MND. …
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Análises de redes modulares de co-expressão gênica revelam vias importantes na doença de Alzheimer e paralisia supranuclear progressiva
… with neurodegenerative diseases (Alzheimer or Progressive Supranuclear Palsy) and two animal models, 5XFAD of amyloidopathy and TauD35 of tauopathy, we performed an integrative analysis at the gene/transcript level combined with a co-expression analysis to identify similarities and …
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Regulation of Transglutaminase by 5-HT2A Receptor Signaling and Calmodulin
… disease (HD), Alzheimer disease’s, and progressive supranuclear palsy. Mutant huntingtin (htt) and small G proteins (e.g. Rac 1) are potential substrates of TGases. The purpose of this dissertation was to characterize the mechanisms by which 5-HT2A receptor signaling and calmodulin (CaM) …
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In vivo pathology markers in tauopathies: prognostic and diagnostic implications
… dementia (half due to tauopathy), and progressive supranuclear palsy (PSP). In addition to abnormal accumulation of tau protein, they are each characterised by neuroinflammation, with increasing evidence that the neuroinflammation plays a role in the onset and progression of these …
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The Prostaglandin E2 Receptor Subtype 3E and its involvement in tauopathies
Neuroinflammation is becoming increasingly recognised as key to the pathogenesis of Alzheimer’s disease and tauopthies. Epidemiological studies report a delay in the onset of Alzheimer’s in subjects using nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs inhibit enzymes in the cyclooxygenase-2 …
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The Physiology of Dementia: Network reorganisation in progressive non-fluent aphasia as a model of neurodegeneration
The dementias are persistent or progressive disorders affecting more than one cognitive domain that interfere with an individual’s ability to function at work or home, and represent a decline from a previous level of function. In this thesis I consider the neurophysiology of dementia at a number of …