Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Progressive Multiple Sclerosis"”.
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Cytosolic Nucleic Acid Sensing and Senescence in a Patient-Derived Model of Progressive Multiple Sclerosis
Multiple Sclerosis (MS) is an inflammatory, autoimmune disorder of the central nervous system (CNS) affecting 2.8 million people worldwide and characterised by an attack by adaptive immune cells against myelin. For reasons not yet fully understood, most patients eventually transition to a disease …
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Exploring MicroRNA as a Biomarker for Multiple Sclerosis (EMBleMS): A Pilot Study
Multiple Sclerosis, a leading cause of disability in young adults, is typically diagnosed as relapsing remitting at onset, however, most patients will eventually transition to a progressive course. This secondary progressive form is difficult to identify and typically not treated therapeutically …
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Investigating Potential Quantitative Trait Loci for Susceptibility to Experimental Autoimmune Encephalomyelitis in the BXD Family of Mice
Multiple Sclerosis is an autoimmune inflammatory condition that causes disability, axonal damage in the central nervous system, and eventual paralysis. One of the main risk factors for developing MS is genetics, with recent studies identifying multiple risk alleles associated the major …
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Engineering Myeloid Cell Phenotype Using Cell Surface-Adhered Microparticles for Therapeutic Applications
… adhered to monocytes in a mouse model of progressive multiple sclerosis to determine immunomodulatory effects and therapeutic efficacy. Then, I scale up the fabrication of backpack-macrophages and apply this treatment in a clinically relevant porcine model of traumatic brain injury. …
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Smoking and Multiple Sclerosis: A Systematic Review and Meta-Analysis Using the Bradford Hill Criteria for Causation
Background. Multiple sclerosis (MS) is one of the most common neurological disorders in the world. However, the cause(s) of MS is unknown. Studies have suggested that smoking may be related to the development and progression of MS. The Bradford Hill criteria are commonly used to assess potentially …
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Mitochondrial dynamics in demyelinated axons in a cerebellar slice culture system
… degeneration is the major cause of disability in progressive multiple sclerosis (MS). It has been shown that in MS and relevant disease models, demyelinated axons harbor an increased number of mitochondria, which is reflected in bigger stationary sites of mitochondria, increased mitochondrial …