Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Programmed necrosis"”.
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The Role of Bax and Bak in Necrotic Cell Death
Historically, necrosis has been viewed as a non-regulated form of cell death. Recently studies have shown that necrosis, like apoptosis, can be a regulated form of cell death, suggesting the existence of a programmed necrotic pathway. For instance, necrotic cell death is inhibited in cells …
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Role of RIP3 in DNA damaging agent-induced breast cancer cell death
… kinase 3 (RIP3 or RIPK3) is a central player in “programmed” or “regulated” necrotic cell death pathway. Here we show that programmed necrosis is activated in response to chemotherapeutic agents and contributes to chemotherapy-induced breast cancer cell death. However, we also show that RIP3 …
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N-ethylmaleimide sensitive factor (NSF) is a regulator of plasma membrane rupture and necrotic cell death
Necrosis, originally considered chaotic, has been found to be regulated by distinct molecular pathways. To identify novel regulators of plasma membrane rupture, a hallmark of necrotic cell death, a genome-wide shRNA loss-of-function screen was performed. We identified SNARE complex members, …
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Ferroptosis: A Novel Form of Cancer Cell Death Induced by the Small Molecule Erastin
… as apoptosis, autophagic cell death, accidental necrosis, and various forms of programmed necrosis. Ferroptosis involves generation of death-inducing reactive oxygen species (ROS), and I show that this ROS production depends upon activity of NADPH oxidase-1 and pentose phosphate pathway-derived …
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NQO1-Bioactivatable Drugs at the Interface of Cancer Metabolism and the DNA Damage Response
… tumors, but not normal tissue, to ß-lap-induced programmed necrosis in vitro and in vivo. Downstream of ROS formation, another mechanism by which tumors can attenuate ß-lap efficacy is through the repair of DNA lesions, specifically through base excision repair (BER). The latter half of this …
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Mitochondrial Dynamics: Exploring A Novel Target Against Myocardial Ischemia-Reperfusion Injury
… of Necrostatin-1, suggesting that necroptosis (programmed necrosis) may play a role in this phenomenon. </p> <p>In conclusion, our results show that DRP1 translocation to mitochondria plays a mechanistic role in mediating cardiomyocyte injury in the context of hypoxia-reoxygenation injury, and …
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Multiplexed biochemical imaging reveals the extent and complexity of non-genetic heterogeneity in DNA damage-induced caspase dynamics.
… each cell adopts, such as apoptosis and programmed necrosis. Finally, deconvolution of cellular populations and direct measurement of a three-node caspase network - formerly impossible - permitted us to design perturbations of cell fate choices utilizing clinically relevant inhibitors. …
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Study of Regulated Cell Death In Two Systems: Pd-1 In Natural Killer Cells and Rip3 In Neurons
… the study of two key molecules involved in RCD: programmed death 1 (PD-1, as inhibitor for RCD) and serine/threonine kinase receptor interaction protein 3 (RIP3, as promoter for RCD) in two different systems.</p> <p>First, I studied the role of PD-1 signaling in the cytotoxicity of natural killer …
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Identifying novel drugs for the treatment of rhabdomyosarcoma
… AJ-5 is also capable of triggering a form of programmed necrosis. Furthermore, AJ-5 reduced autophagic flux as shown by reduced LC3II accumulation in the presence of bafilomycin A1, and a significant reduction in autophagosome flux J. Pharmacokinetic studies in mice show that AJ-5 has a …