Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Programmed axon death"”.
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Chronic activation and downstream mechanisms of programmed axon death
Axon loss is a characteristic feature shared among various neurodegenerative disorders, regardless of their distinct primary causes. Programmed axon death is a conserved, well-characterised pathway of axon degeneration activated by physical injury and in disease states. The two main regulators of …
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Programmed axon death as a driver of environmental neurotoxicity triggered by pyridine derivatives
Programmed axon death is a well-characterized, preventable pathway leading to axon degeneration. Programmed axon death is regulated by SARM1, a pro-degenerative, multi- functional enzyme that consumes NAD and NADP, with dramatic consequences for neuron energy metabolism. Accumulating evidence in …
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Exploring the role of programmed axon death genes SARM1 and NMNAT2 in human disease
Programmed axon death (PAD) is an evolutionary-conserved path of axon destruction initiated by injury and disease. Two proteins are known to profoundly influence axonal health: the pro-death SARM1 and its upstream regulator, the pro-survival NMNAT2. Notably, complete removal of SARM1 has been shown …
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Exploring SARM1 as a target to delay programmed axon degeneration
Programmed axon degeneration (Wallerian degeneration) can occur after physical injury, inhibition of axon transport, exposure to neurotoxic compounds, and in diseases involving mitochondrial or metabolic dysfunction. There is increasing evidence that this pathway can be activated in human painful …