Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Programmed Axon Degeneration"”.
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Exploring SARM1 as a target to delay programmed axon degeneration
Programmed axon degeneration (Wallerian degeneration) can occur after physical injury, inhibition of axon transport, exposure to neurotoxic compounds, and in diseases involving mitochondrial or metabolic dysfunction. There is increasing evidence that this pathway can be activated in human painful …
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Mutational and Structural Investigation of SARM1, a Protein that Mediates Axon Loss
… is a pro-degenerative NADase that executes the programmed axon degeneration pathway after nerve injury and in diseases including polyneuropathies. The ARM domain of SARM1 plays a crucial role in regulating its NADase activity. By attenuating this activity, axon degeneration is delayed, making …