Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 66 for “"Prognostic Markers"”.
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Study of prognostic markers in advanced cancer
BACKGROUND: Prognostication is a core skill fundamental to the clinical management of patients with advanced cancer. This skill is exercised to guide appropriate clinical decisions, plan supportive services and allocate resource utilisation. Prognostication by clinicians is often erroneous, …
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Novel Immunometabolic Therapies and Prognostic Markers for Lymphedema
… to target lymphedema fibrosis, and improved prognostic models are required to reliably predict who will develop chronic, severe lymphedema to appropriately triage and monitor patients for timely diagnosis and treatment. It is unknown if: (1) gene expression changes in tissue are associated …
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Juvenile pilocytic astrocytomas: A search for prognostic markers
… this pathway in an effort to establish reliable prognostic and predictive markers. Aims and objectives: Our study was aimed at reviewing the light microscopic features and also evaluating the BRAF, p16 and protein kinase ERK components of the MAPK pathway. The findings thereof were correlated …
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Novel Prognostic Markers and Therapeutic Targets for Glioblastoma
… grim outcome derive from the lack of applicable prognostic markers and effective therapeutic targets. By employing a loss of function RNAi screen in glioblastoma cells we found a list of 20 kinases that can be considered glioblastoma survival kinases. These survival kinases which we term as …
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Identification Of Neuroblastoma And Its Prognostic Markers Using Raman Spectroscopy
… the first in-depth examination of specific markers of aggressiveness, including tumor favorability and MYCN gene amplification. Raman spectroscopy has the potential to revolutionize the field of cancer diagnostics. It can provide a detailed, accurate diagnosis in minutes instead of days.</p>
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Oral and Oropharyngeal Cancer - Aspects on Epidemiology and Prognostic Markers
… a previous study been found to be an independent prognostic marker for poor outcome in head and neck SCC. This thesis aimed to investigate the epidemiological changes for tongue cancer in the Nordic countries and to compare some possible predictive factors for OOPHSCC. During the period 1960-1994, …
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Testicular cancer – response adapted treatment, prognostic markers and survivorship issues
… of the study was to examine the expression and prognostic ability of RBM3 in patients with testicular non-seminomatous germ cell tumors (NSGCT). Low RBM3 expression was a predictor of treatment failure in metastatic NSGCT, in relation to the prognostic factors included in the International Germ …
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Prognostic Markers and Mechanisms of Chemotherapy Resistance in Diffuse Large B-cell Lymphoma
… and heterogeneous disease. Identification of prognostic and predictive markers is important to design individualised and effective treatment strategies. This thesis describes different approaches to search for molecular prognostic markers and an attempt to overcome chemotherapy resistance in …
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AN EXPANSION ON DIAGNOSTIC AND PROGNOSTIC MARKERS IN DOGS WITH ACUTE AND CHRONIC HEART FAILURE
… a better understanding of the diagnostic and prognostic significance of different markers related to the primary aspects of the HF syndrome in dogs: neurohormonal dysregulation and multi-organ damage. The present project consists of four distinct investigations. The first study evaluated the …
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Regulatory T cells and circulating cytokines : novel prognostic markers in squamous cells carcinoma of the head & neck
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common type of cancer worldwide and is considered a highly immunosuppressive tumour. Advances in the treatment modalities for HNSCC over the last 20 years involving surgery, radiotherapy, chemotherapy and immunotherapy are not fully …
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Novel Rac1/Stat3 and Stat5 Pathway in Differentiation and Neoplastic Transformation of Breast Epithelial Cells: Potential Prognostic Markers
… Stat3 and Stat5 may turn out to be independent prognostic markers for breast cancer. We show here, through pharmacological inhibition experiments, that Stat3 is required for differentiation of HC11 breast epithelial cells, measured by β-casein expression. On the other hand, we also show that …
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Prognostic markers associated with tyrosine kinase inhibitor treatment response and maintenance of treatment free remission in chronic myeloid leukaemia
… The aim of this thesis is to identify prognostic markers that may help individualise treatment and optimise outcome by stratifying patients into risk groups. Selective treatment intensification is important - more potent treatment may be associated with increased toxicity, and universal …
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Prognostic Markers for Recovery of Aphasia after Acute Ischemic Stroke // Прогностични маркери за възстановяване на афазията след остър исхемичен инсулт
Инсултът по определение на Световната здравна организация е бързо развитие на клинични признаци на фокални смущения мозъчна функция, продължаващи повече от 24 часа или водещи до смърт, без друга причина, различна от съдов произход. Субарахноидалното кървене не е включено. Нарушенията на езиковата …
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Evaluation of the P13K pathway and downstream effect in Her-2 positive and negative breast carcinomas
… were evaluated for their relevance as potential prognostic markers or indicators for treatment. A secondary objective was to evaluate the CISH technique for its suitability for analysis of Her-2 gene amplification on archived, Papanicolaou-stained fine needle aspiration (FNA) samples. Tissue …
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Expression of Survivin : Possible Predictor of Local Recurrence after Curative Resection for Rectal Cancer
… CCRT). There is a need for better prognostic markers due to the varieties of treatment response within same clinicopathologic stage. Survivin, a novel member of IAP protein, is often associated with increasing recurrence risk and poor prognosis. We investigated the expression of …
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Detection of Novel Genomic Markers for Predicting Prognosis in Hepatocellular Carcinoma Patients by Integrative Analysis of Copy Number Aberrations and Gene Expression Profiles: Results from a Long-Term Follow-Up
… follow-up data successfully identified potential prognostic markers predicting survival and tumor recurrence in patients with HCC who underwent surgical resection.
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FUNCTIONAL ROLE OF NON-CODING REGULATORY VARIANTS IN NEUROBLASTOMA
… poor survival and unfavourable neuroblastoma prognostic markers. The aim of this work is to functionally investigate the pathogenic effects of SNVs falling in regulatory elements, suggesting that they may cause transcriptional networks deregulation in disease pathogenesis and affect target …
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The impact of undernutrition on tuberculosis prevalence and treatment outcomes in Ethiopia
… intervention on TB treatment adherence, prognostic markers, and treatment outcomes (objective 4). Various study designs and statistical analyses were used to address the thesis objectives. A Bayesian model-based geostatistics was used to investigate the geospatial overlap of …
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The impact of undernutrition on tuberculosis prevalence and treatment outcomes in Ethiopia
… intervention on TB treatment adherence, prognostic markers, and treatment outcomes (objective 4). Various study designs and statistical analyses were used to address the thesis objectives. A Bayesian model-based geostatistics was used to investigate the geospatial overlap of …
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Identification of epigenetically dysregulated genes in tumours that metastasise to the brain
… that these genes could be used as a panel of prognostic markers or as therapeutic targets for BBM.
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