Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Prognostic Biomarker"”.
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Prognostic biomarker discovery from omics data using machine learning approaches
Prognostic biomarker discovery from omics data using machine learning approaches by Manik Garg Prognostic biomarkers can help clinicians identify high-risk patients to administer appropriate therapies. The omics data from patient samples can be used to find such biomarkers. Moreover, molecular …
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Exploring the potential application of glucuronides as a prognostic biomarker for disease.
… is important to clarify the concept for disease prognostics based on glucuronide species in their excretion. Therefore, the aim of the research is to explore the potential application of glucuronides for disease prognosis and disease, by revealing the relationship between glucuronides and …
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The Notch Target Hes4 Promotes Osteosarcoma Tumor Growth and Metastasis By Inhibiting Osteogenic Differentiation, and Has Potential As A Prognostic Biomarker For Newly Diagnosed Patients With High Grade Osteosarcoma.
<p>Currently, there are no well-established prognostic biomarkers for osteosarcoma (OS) at the time of diagnosis. Although response to preoperative chemotherapy correlates with metastasis risk and overall survival, this information is obtained 3-4 months after the initial diagnosis. The major …
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Catalytic-Independent And Subtype-Specific Roles Of Fructose-1,6-Bisphosphatase 2 In Sarcoma Growth
… progression, highlighting its potential as a prognostic biomarker in STS.
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A novel in vivo tumor oxygen profiling assay: Combining functional and molecular imaging with multivariate mathematical modeling
… using the overall or average tumor hypoxia as a prognostic biomarker of anti-angiogenic therapy efficacy was ambivalent; however, recent studies have discovered that the etiology of hypoxia and its heterogeneity could be used as reliable prognostic biomarkers. The capability to longitudinally map …
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Statistical Methods For The Analysis And Development Of Quantitative Imaging Biomarkers
… these summaries should provide interpretable biomarker measurements that can guide patient diagnoses or treatment decisions while minimizing information loss associated with dimension reduction. This dissertation is focused on (1) exploring methods for analyzing previously developed imaging …
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A Rapid Colorimetric Peptide Nucleic Acid Loop-Mediated Isothermal Amplification Assay for the Detection of the IDH1 Mutation in Glioblastoma
… mutation is an important diagnostic and prognostic biomarker used to characterize glioblastoma (GBM). Patients harboring the <em>IDH1</em> mutation have improved overall survival following maximal resection. Knowledge of the <em>IDH1</em> mutation status allows the surgeon to modify the …
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Novel Immunometabolic Therapies and Prognostic Markers for Lymphedema
… to target lymphedema fibrosis, and improved prognostic models are required to reliably predict who will develop chronic, severe lymphedema to appropriately triage and monitor patients for timely diagnosis and treatment. It is unknown if: (1) gene expression changes in tissue are associated …
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Diagnostic and Prognostic Biomarkers for Early Prostate Cancer
… is an urgent need for robust diagnostic and prognostic biomarkers that can accurately identify patients with prostate cancer and stratify them according to the risk of developing aggressive disease state. We addressed this issue by focusing on DNA methylation, and PTEN and ERG protein markers …
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Automatic Pancreas Segmentation and 3D Reconstruction for Morphological Feature Extraction in Medical Image Analysis
… for example, the pancreas volume provides a prognostic biomarker about the severity of type 2 diabetes mellitus. Furthermore, a generalisation of the proposed segmentation approach successfully extends to other anatomical structures, including the kidneys, liver and iliopsoas muscles using …
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Hsp27 and Chemotherapy-Induced Autophagy As Biomarkers In Osteosarcoma
… LC3B-puncta expression was an independent poor prognostic marker at resection (adjusted HR 1.75, <em>p=</em>0.045). Patients with LC3B+/HSP27- tumors at resection had the best prognosis whereas patients with LC3B-/HSP27+ osteosarcoma had the worst long-term survival. Neither HSP27 nor LC3B …
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Tp53 As A Biomarker In Head and Neck Squamous Cell Carcinoma
<p>Currently, there are no molecular biomarkers that guide treatment decisions for patients with head and neck squamous cell carcinoma (HNSCC). Several retrospective studies have evaluated TP53 in HNSCC, and results have suggested that specific mutations are associated with poor outcome. However, …
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Roles of the MicroRNA miR-31 in tumor metastasis and an experimental system for the unbiased discovery of genes relevant for breast cancer metastasis
… that miR-31 may represent a clinically useful prognostic biomarker and/or therapeutic target in certain aggressive human carcinomas. In addition, a novel experimental system for the unbiased identification of metastasisrelevant genes was described. The utility of this system was demonstrated in …
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Bhlhe40: Required For Tumor Microenvironment Remodeling and Immune Checkpoint Therapy Efficacy
… and suggest that BHLHE40 may be a predictive or prognostic biomarker for ICT efficacy and a potential therapeutic target.</p>
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Expression and function of osteopontin variants in HCV-related liver disease and hepatocellular carcinoma.
… potential as both a diagnostic and potentially prognostic biomarker for not only HCC (arising from HBV and HCV infections and alcohol abuse) but also the earlier stages of HCV-related liver disease. This work for the first time characterises the expression of all OPN variants in the liver …
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Epigenetic dysregulation of novel candidate genes in melanoma
… therefore urgently required. Development of such biomarkers, combining sensitivity and specificity, would allow the deployment of these treatments when tumour volume is low thereby maximising anti-melanoma efficacy. Cancer-associated gene promoter methylation is recognized as an important …
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Induced Gene Expression In Bladder Cancer: Kindlin-2 And Metallothionein-1x
… component. Currently, there are no stand-alone biomarkers for this type of cancer.</p> <p>Kindlin-2 and Metallothionein (MT) isoform-1X (MT-1X) are two genes that are the focus of this dissertation. Both genes were selected for further experimental analysis based on their common association with …
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Quantitative analysis of neuropilin-2 expression in pigmented lesions and melanoma
… may prove to be extremely valuable as a prognostic marker for primary melanoma tumors. In addition, it may serve to identify subsets of early stage tumors that would benefit from adjuvant therapy. This study aimed to demonstrate if there is a relationship between the level of expression …
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Identifying new actions of estrogen receptor targetable with small molecules
… and that a UPR gene signature is a powerful new prognostic biomarker predictive of resistance to tamoxifen therapy, time to relapse, and overall survival. We employed a novel approach to identifying new pathways and cancer biomarkers in which unbiased high throughput screening is used to …
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IDENTIFICATION OF NCAM1 AS A NOVEL PROGNOSTIC PROSTATE CANCER STEM CELL BIOMARKER
… (NE) cells, as a novel PCSC marker that provides prognostic information and molecular insights into the process of tumorigenesis. NCAM1 defines clusters of cells enriched in proliferative inflammatory atrophy (PIA) regions, without NE traits (hereafter referred as NCAM1+). In a retrospective …
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