Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 894 for “"Progenitor"”.
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Transposable Elements in Neural Progenitor Cells
… called Line-1 was found to be active in neural progenitor cells and in the brain. Several studies report Line-1 transcription and frequent retrotransposition during normal brain development, with further evidence that Line-1 induced retrotransposition can influence neuronal gene expression. …
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Haematopoietic progenitor cells in carotid disease
Introduction Haematopoietic progenitor cells (HPCs) may attenuate the response to acute vascular injury by maintaining endothelial integrity and function. The aim of this study was to determine whether circulating HPC number and function, and mobilising cytokines, reflect significant carotid …
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Liver regeneration by hepatic progenitor cells
… with stem cell like qualities known as hepatic progenitor cells (HPCs). HPCs are particularly active during massive or chronic liver injury and therefore are an attractive target for much needed novel therapies to enhance regeneration in patients for whom the only current effective therapy is …
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Engineered microenvironments for studying liver progenitor differentiation
The bipotential differentiation of liver progenitor cells underlies liver development and bile duct formation as well as liver regeneration and disease. Both TGFβ and Notch signaling are known to play important roles in the liver progenitor specification process and subsequent tissue morphogenesis. …
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Chondrogenic capacities of equine synovial progenitor populations
… program is to provide strategies using synovial progenitor populations for articular cartilage repair in horses. The synovial fluid samples were added directly to culture medium and maintained until confluence. The primary cultures were passage twice to generate sufficient cell numbers for …
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Epigenetic Regulation of Muscle Stem and Progenitor Cells
… The mechanisms regulating muscle stem and progenitor cell identity have ramifications for understanding all aspects of myogenesis. The epigenetic mechanisms regulating muscle stem cells are therefore important aspects for understanding the regulation of muscle regeneration and maintenance. …
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Studies on renal progenitor cells and kidney cancer
Kidney cancer and renal injuries affect millions of people in the world resulting in high patient morbidity and mortality, as well as one of the most extensive medical costs for society. Upon renal injury the kidney has an endogenous ability to repair damaged tubules and restore kidney function, …
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Redefining endothelial progenitor cells using a proteomics approach
The concept of endothelial progenitor cells (EPCs) has attracted considerable interest in cardiovascular research, but despite a decade of research there are still no specific markers for EPCs and results from clinical trials remain controversial. To identify membrane proteins, which could serve as …
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Neural Stem / Progenitor Cells in the Adult Mouse Hypothalamus
… My work confirms the presence of stem / progenitor cells in the adult mouse hypothalamus. Analysis of neural ‘stem cell markers,’ both in vivo and in vitro, suggests the presence of different populations of stem / progenitor cells occupying discrete territories of the ependymal zone. Some …
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Olfactory progenitor cell transplantation into the mammalian inner ear
… hypothesis that olfactory neurosphere (ONS) and progenitor cells harvested from the olfactory epithelium represent a viable source of graft material for potential therapeutic applications in the inner ear. Olfactory epithelium represents a unique source of pluripotent cells that may serve as …
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The transcriptional regulation of skeletal muscle progenitor cell fate
… events that lead to the expression of muscle progenitor markers. This series of studies aims to further understand the mechanisms which regulate commitment to the myogenic lineage. In Chapter 2, Sox 15 was found to be sufficient for the expression of pre-skeletal mesodermal markers, but failed …
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Identification and characterization of epithelial progenitor niches in skin
The skin contains a highly regionalized stem and progenitor cell niche system, where a particular epithelial progenitor population primarily displays unipotent or bipotent behavior by contributing to their local niche under homeostatic conditions. Some of these populations, however, can also …
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The role of UCH-L1 in mouse progenitor spermatogonia
To maintain fertility throughout the life of the adult male, the spermatogonial stem cell (SSC) population of the testis needs to achieve a balance between self-renewal and differentiation. The chemical, molecular and physical environment that supports this balance of fate decision is not …
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Cytokine-Induced Igf-I Resistance in Progenitor Muscle Cells
… that are needed for differentiation of murine progenitor muscle cells. We significantly extend these results by showing that cytokine-induced IGF-I resistance in myoblasts is mediated by activation of ceramide generating pathways, including N-SMase, A-SMase and de novo ceramide synthesis. The …
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Novel intracellular signalling regulators of cartilage progenitor cell populations
… OA, but also uncover the relevance of cartilage progenitors loss in the development of cartilage degeneration.
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Generation of induced progenitor-like (iPL) cells using interrupted reprogramming
… the pluripotent state, to generate "induced Progenitor-Like (iPL) cells" using carefully timed transient expression of induced Pluripotent Stem (iPS) cell reprogramming factors (Oct4, Sox2, Klf4 and c-Myc; OSKM). Interrupted reprogramming is not only able to achieve controlled expansion of …
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Role of Fra-2/AP-1 in Myogenic Progenitor Cells
Components of AP-1 have dynamic expression profiles during myogenesis in C2C12 cells, the expression profile of AP-1 is different among proliferative myoblasts, differentiating myoblasts, differentiated myotubes and reserve cells, indicating context-dependent spatial and temporal roles. We found …
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