Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Product release"”.
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Improving product release from saccharomyces cerevisiae and kluyveromyces lactis by pretreatment for cell wall weakening and selective product release
Efficient intracellular product release from yeast is required for the recovery of many bioproducts, recombinant or other. Traditionally such product release is achieved by non-selective, energy demanding mechanical disruption. The fine debris resulting from mechanical disruption is also …
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A detailed investigation of microbial cell disruption by hydrodynamic cavitation for selective product release
… by cavity oscillation and collapse. Selective release of intracellular microbial products is desirable to reduce the cost involved in their downstream processing. A study of the process variables that affect microbial cell disruption by hydrodynamic cavitation is presented in order to ascertain …
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Structural Basis for Protein Recognition, Acyl-substrate Delivery, and Product Release by ACP in the Biosynthesis of Lipid A
… which represent stalled substrate and breakage products along the reaction coordinate. The structures reveal the intricate interactions at the interface that optimally position ACP for acyl-delivery and directly involve the pantetheinyl group. Conformational differences among the stalled ACPs …
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Aging and Copper Corrosion By-Product Release: Role of Common Anions, Impact of Silica and Chlorine, and Mitigating Release in New Pipe
… factor controlling the maximum soluble copper release. Gradual replacement of soluble Cu(OH)2 scale to less soluble scale is desirable and occurs through a process known as "aging. The presence of sulfate, bicarbonate and orthophosphate in water can quickly convert Cu(OH)2 to less soluble …
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Biochemical characterization of five GH130-family enzymes from Caldanaerobius polysaccharolyticus ATCC BAA-17 and insights on their metabolic role and reaction mechanisms
… residues, with the subsequent release of α-mannose-1-phosphate. In this study, we compare five different GH130 enzymes (CpMan130 A-E) encoded within the genome of Caldanaerobius polysaccharolyticus, a thermophilic anaerobic bacterium able to ferment mannan as the sole carbon …
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Operationalizing Psychophysiological Correlates of Mobile App User Experience
… are expensive and do not scale well to every product release, demographic, and geography. ‘Real Time UX’ is a phone case that measures several biometric signals available at the user’s hands and uses these data to infer stress, frustration, and engagement in context of app behavior. This …
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Formation of Aluminum Containing Solids in Drinking Water: Influence on Pb/Cu Corrosion, Al Solubility and Enhanced Softening
… could further worsen corrosion by-product release. The second phase of work attempted to extend understanding of aluminum solubility controls by accounting for effects of sulfate and formation of solids other than Al(OH)₃ during water treatment. Sulfate was found to destabilize …
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Mechanistic Elucidation of M-PR2NRʹ2 Catalysts for Hydrofunctionalization and Cross Coupling Reactions
… species was observed, which completely arrested productive catalysis, but gave insight into organic product release steps of the mechanism. Isolation of two vinylidene complexes enabled stoichiometric investigations to assess intermolecular hydroamination. Stoichiometric reactions with the …
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Essays On Dynamic Updating Of Consumer Preferences
… over time based on information learned through product search and consumption experiences, particularly in online media. Using three unique datasets from different domains, we address specific ways in which firms can use rich information about their customers' behaviors to improve (1) the visual …
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Copper in the Urban Water Cycle: Sources and Sinks, Benefits and Detriments, and Corrosion in Soft Waters
… to have minimally adverse effects on copper release at pH 9.5 but no significant effect at pH 7.0, and higher temperatures usually increased copper release. Organic matter including soluble and particulate NOM, sodium alginate, and gum xanthan, tended to worsen copper release. Their direct …
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Insights into the mechanisms of translation surveillance using constitutive RNA binding ASC-1 complex mutants
… an inducible cell line that expresses an ASCC3 product- release trap mutant, capable of interacting with its RNA partners in the absence of exogenous translational stress. Using this cell line, I have investigated the role of ASCC3 in transla- tion surveillance under steady-state cellular …
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Developing criteria for PC-CADD evaluations : a case study
While the usefulness of CADD in the production stages of the architectural design process is now widely acknowledged, its true benefits for earlier, schematic design phases remain unclear. Due to the very subjective nature of that process and the complexity of its overlap with other design stages, …
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Operational decisions and learning for multiproduct retail
We study multi-product revenue management problems, focusing on the role of uncertainty in both the seller and the customer decision processes. We begin by considering a logit model framework for personalized revenue management problems where utilities are functions of customer attributes, so that …
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PLP-Dependent α-Oxoamine Synthases: Phylogenetic Analysis, Structural Plasticity, and Structure-Function Studies on 5-Aminolevulinate Synthase
… of conformational changes associated with product release due to the strain caused with the linking the two ALAS (or ALAS and AONS) subunits. Thus, the extensive plasticity seen in ALAS extends to another member of the α-oxoamine family, AONS. In the α-oxoamine synthase family a conserved …
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Investigating the rate-limiting step of mitochondrial complex I catalysis
… transfer chain (ETC). It couples the energy released from NADH oxidation and ubiquinone (Q) reduction to the translocation of four protons across the inner mitochondrial membrane, contributing to the proton motive force (PMF) used to synthesise ATP. Although structural knowledge of complex I …
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Advancing the Understanding of Water Distribution System Corrosion: Effects of Chlorine and Aluminum on Copper Pitting, Temperature Gradients on Copper Corrosion, and Silica on Iron Release
… to increase copper pitting frequency and copper release to drinking water. Experiments examined the effect of temperature gradients on copper pipe corrosion during stagnant conditions. The pipe orientation in relation to the temperature gradient determined whether convective mixing would occur, …
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Understanding the ATP hydrolysis mechanism in myosin using computer simulation techniques
… of the positions of the protons. In the product states, the coordination bond between Mg2+ and Ser237 (and thus the switch-1 loop) is broken. This indicates that product release is likely to occur via an exit route that opens by complete opening of the switch-1 loop ("trap door" …
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Investigation of Slow Dynamics in Proteins: NMR Pulse Sequence Development and Application in Triosephosphate Isomerase
… studied and been proven to be correlated with product release and be a rate-limiting step for the catalysis. Another highly conserved loop near the active site, loop 7 also has large changes in dihedral angles during ligand binding. Its motion is suspected to be correlated with loop 6 based on …
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Applications of Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS) in pharmaceutical analysis
… is a cornerstone of quality control testing and product release. Dissolution testing is a prerequisite for the quality control and release to market of nearly every prescription and over the counter product. It is one of the few technologies which has not undergone disruption of any kind. …