Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Processivity Factor"”.
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KSHV encoded viral processivity factor, ORF59, regulates multiple pathways for viral replication
… risk for developing lethal cancers. ORF59, a DNA processivity factor of the viral DNA polymerase, is essential for lytic reactivation and is highly expressed during de novo primary infection. To better understand the role of ORF59, we performed an ORF59-immunoprecipitation from KSHV infected cells …
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Clamp loading on the leading strand during DNA replication and initial reconstitution of sister chromatid cohesion establishment
… and a wide range of replisome-associated factors. One such factor is the sliding clamp PCNA, which acts as both a processivity factor to support fast and efficient DNA synthesis and as a recruitment platform in various genomic stability maintenance processes downstream of DNA replication. …
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DNA crosslink repair safeguards genomic stability during pre-meiotic germ cell development
… find that PGCs unable to modify the replication processivity factor, PCNA, a prerequisite for efficient TLS, fail to undergo DNA demethylation, a key feature of epigenetic reprogramming and thus germ cell development.
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The Role of ORF59 and PAN ENE in Viral Replication of KSHV
… episodes of reactivation due to a variety of factors including environmental stimuli or waning immunity. Particularly, in immune-compromised individuals, reactivation can result in the production of new infectious virions which can in turn drive the progression of KSHV-associated malignancies. …
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Replication-associated base excision repair Of oxidized bases in the mammalian genome
… 1 (FEN1), DNA Polymerase ä, Replication Factor C (RFC), and DNA Ligase I as well as the stress responsive Rad9-Rad1-Hus1 (9-1-1) DNA sliding clamp. We mapped the overlapping binding sites for all of these interacting protein partners to a small disordered region near the unconserved …
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HDAC6 activity is required for efficient polarization and intracellular transport of organelles in directionally migrating cells
… dynein and its MT plus-end binding partner and processivity factor, p150Glued, known to be involved in MTOC reorientation via a MT capture mechanism, were also compromised in the absence of HDAC6 activity. In addition, polarized bi-directional transport of Golgi vesicles in motile cells was …