Global ETD Search
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Showing 1 to 2 of 2 for “"Procaspase-3 activation"”.
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Procaspase-3 activation as a strategy to overcome resistance to targeted anticancer therapies
… the zymogen of the executioner caspase, procaspase-3, rather than being downregulated in cancer, has been found to be overexpressed in many cancers. In Chapter 1, I will describe the list of cancers that overexpress procaspase-3, before rationalizing this paradoxical observation. Finally, …
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Development of PAC-1 as a privileged agent for combination chemotherapy
… cellular alterations. Small-molecule activation of procaspase-3 represents a particularly promising opportunity, based upon its determinant role in the execution of apoptosis and its widespread over-expression across many diverse cancer types. PAC-1 is a small-molecule that facilitates …