Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Pro-survival pathways"”.
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Pharmacological activation of pro-survival pathways as a strategy for improving donor heart preservation
… the quality of the donor heart may still be compromised by its obligatory exposure to periods of ischaemia (both cold and warm) followed by reperfusion upon reintroduction of the recipient circulation. This is reflected in Transplant Registry data showing increased primary allograft failure as a …
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The role of sphingosine kinases and dihydroceramide desaturase in cell survival/apoptosis and inflammation pathways
… desaturase (Degs1) in regulating cell survival/apoptosis and therefore this study primarily examined the molecular basis of the reported opposing roles of Degs1. The sphingosine kinase inhibitor SKi [2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole] or the Degs1 inhibitor fenretinide …
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Histone Lysine Demethylase KDM4A as a Therapeutic Target for Small Cell Lung Cancer
… suggesting that none of these drugs would provide benefits against SCLC beyond those of current chemotherapy. By analyzing publicly available data from shRNA and CRISPR screens in addition to our own RNA-seq expression data, I identified KDM4A as a potential candidate to target in SCLC. To …
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Mechanisms of Ipsapirone-Mediated Neuroprotection of Ethanol-Treated Fetal Rhombencephalic Neurons: Role of Endogenous Antioxidants
… by which 5-HT1A agonists exert their neuroprotective effects appears to involve activation of the phosphatidylinositol 3'kinase (PI-3K) pro-survival pathway and activation of NF-κB dependent anti-apoptotic genes. Additional NF-κB dependent genes might also be involved with the …
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Extracellular Superoxide Dismutase Protects Cardiomyocytes During Hyperoxia
… and that a biogenic response is needed for cell survival. The study was done in mice with a transgene (TG) for extracellular superoxide dismutase (EC-SOD) or with the EC-SOD gene knockout (KO). Adult EC-SOD mice and their wild type littermates and EC-SOD KO mice and their wild type littermates …
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The Role of a Membrane Androgen Receptron in the Brain
… on the insult type, androgens have been shown to protect from or exacerbate the levels of cell death. This discrepancy is partly due to the array of receptors that androgens may activate during injury. For example, activation of intracellular androgen receptors (AR) leads to the activation of …
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PHYTOCHEMICAL AND SYNTHETIC INVESTIGATIONAL COMPOUNDS AS MODULATORS OF CYTOMETABOLIC AND CYTOSKELETAL DYNAMICS FOR PRE-CLINICAL TARGETING OF PROSTATE CANCER
Prostate cancer (PC) is the most commonly found malignancy among men globally. Many genetic and epigenetic factors involving multiple cellular signaling networks are implicated in the initiation, progression, and metastasis of this disease. Therapeutic drug resistance and hormone-sensitive and/or …
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Rho GTPases in Neuronal Apoptosis and Neurodegeneration
… Cdc42) as mediators of diverse critical cellular processes, such as actin cytoskeleton remodeling, gene transcription, cell-cell adhesion, and cell cycle progression. However, more recent data highlight an essential role for Rho GTPases as regulators of neuronal morphology and neuronal survival. …
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An investigation into the novel effects of melatonin treatment on differentiated C2C12 myotubes in the absence and presence of pathology
… and act as a potent antioxidant, it has been proposed as an alternative means of treatment for oxidative stress, mitochondrial dysfunction and injury-related damage to skeletal muscle. However, despite its promising therapeutic potential, much remains unknown with regard to its impact on …